2,228 research outputs found
Detecting Pair-Instability Supernovae at z<5 with the James Webb Space Telescope
Pair-instability supernovae (PISNe) are the ultimate cosmic lighthouses,
capable of being observed at z<25 and revealing the properties of primordial
stars at cosmic dawn. But it is now understood that the spectra and light
curves of these events evolved with redshift as the universe became polluted
with heavy elements because chemically enriched stars in this mass range
typically lose most of their hydrogen envelopes and explode as bare helium
cores. The light curves of such transients can be considerably dimmer in the
near infrared (NIR) today than those of primordial PISNe of equal energy and
progenitor mass. Here, we calculate detection rates for PISNe whose progenitors
lost their outer layers to either line-driven winds or rotation at z<10, their
detection limit in redshift for the James Webb Space Telescope (JWST). We find
that JWST may be able to detect only Pop II (metal-poor) PISNe over the
redshift range of z<4, but not their Pop III (metal-free) counterparts.Comment: Accepted for ApJ, in pres
Sharp wave/ripple network oscillations and learning-associated hippocampal maps
Sharp wave/ripple (SWR, 150â250 Hz) hippocampal events have long been postulated to be involved in memory consolidation. However, more recent work has investigated SWRs that occur during active waking behaviour: findings that suggest that SWRs may also play a role in cell assembly strengthening or spatial working memory. Do such theories of SWR function apply to animal learning? This review discusses how general theories linking SWRs to memory-related function may explain circuit mechanisms related to rodent spatial learning and to the associated stabilization of new cognitive maps
Lithologic Influences on Groundwater Recharge through Incised Glacial Till from Profile to Regional Scales: Evidence from Glaciated Eastern Nebraska
[1] Variability in sediment hydraulic properties associated with landscape depositional and erosional features can influence groundwater recharge processes by affecting soil-water storage and transmission. This study considers recharge to aquifers underlying river-incised glaciated terrain where the distribution of clay-rich till is largely intact in upland locations but has been removed by alluvial erosion in stream valleys. In a stream-dissected glacial region in eastern Nebraska (Great Plains region of the United States), recharge estimates were developed for nested profile, aquifer, and regional scales using unsaturated zone profile measurements (matric potentials, Clâ and 3H), groundwater tracers (CFC-12 and SF6), and a remote sensing-assisted water balance model. Results show a consistent influence of till lithology on recharge rates across nested spatial scales despite substantial uncertainty in all recharge estimation methods, suggesting that minimal diffuse recharge occurs through upland glacial till lithology whereas diffuse recharge occurs in river valleys where till is locally absent. Diffuse recharge is estimated to account for a maximum of 61% of total recharge based on comparison of diffuse recharge estimated from the unsaturated zone (0â43 mm yrâ1) and total recharge estimated from groundwater tracers (median 58 mm yrâ1) and water balance modeling (median 56 mm yrâ1). The results underscore the importance of lithologic controls on the distributions of both recharge rates and mechanisms
Tetrode recording from the hippocampus of behaving mice coupled with four-point-irradiation closed-loop optogenetics: A technique to study the contribution of Hippocampal SWR events to learning
With the advent of optogenetics, it became possible to change the activity of a targeted population of neurons in a temporally controlled manner. To combine the advantages of 60-channel in vivo tetrode recording and laser-based optogenetics, we have developed a closed-loop recording system that allows for the actual electrophysiological signal to be used as a trigger for the laser light mediating the optogenetic intervention. We have optimized the weight, size, and shape of the corresponding implant to make it compatible with the size, force, and movements of a behaving mouse, and we have shown that the system can efficiently block sharp wave ripple (SWR) events using those events themselves as a trigger. To demonstrate the full potential of the optogenetic recording system we present a pilot study addressing the contribution of SWR events to learning in a complex behavioral task
Basal forebrain contributes to default mode network regulation
The default mode network (DMN) is a collection of cortical brain regions that is active during states of rest or quiet wakefulness in humans and other mammalian species. A pertinent characteristic of the DMN is a suppression of local field potential gamma activity during cognitive task performance as well as during engagement with external sensory stimuli. Conversely, gamma activity is elevated in the DMN during rest. Here, we document that the rat basal forebrain (BF) exhibits the same pattern of responses, namely pronounced gamma oscillations during quiet wakefulness in the home cage and suppression of this activity during active exploration of an unfamiliar environment. We show that gamma oscillations are localized to the BF and that gamma-band activity in the BF has a directional influence on a hub of the rat DMN, the anterior cingulate cortex, during DMN-dominated brain states. The BF is well known as an ascending, activating, neuromodulatory system involved in wakeâsleep regulation, memory formation, and regulation of sensory information processing. Our findings suggest a hitherto undocumented role of the BF as a subcortical node of the DMN, which we speculate may be important for switching between internally and externally directed brain states. We discuss potential BF projection circuits that could underlie its role in DMN regulation and highlight that certain BF nuclei may provide potential target regions for up- or down-regulation of DMN activity that might prove useful for treatment of DMN dysfunction in conditions such as epilepsy or major depressive disorder
A comparative study to optimize experimental conditions of pentylenetetrazol and pilocarpine-induced epilepsy in zebrafish larvae
The Very Young Type Ia Supernova 2012cg: Discovery and Early-Time Follow-Up Observations
On 2012 May 17.2 UT, only 1.5 +/- 0.2 d after explosion, we discovered SN
2012cg, a Type Ia supernova (SN Ia) in NGC 4424 (d ~ 15 Mpc). As a result of
the newly modified strategy employed by the Lick Observatory SN Search, a
sequence of filtered images was obtained starting 161 s after discovery.
Utilizing recent models describing the interaction of SN ejecta with a
companion star, we rule out a ~1 M_Sun companion for half of all viewing angles
and a red-giant companion for nearly all orientations. SN 2012cg reached a
B-band maximum of 12.09 +/- 0.02 mag on 2012 June 2.0 and took ~17.3 d from
explosion to reach this, typical for SNe Ia. Our pre-maximum brightness
photometry shows a narrower-than-average B-band light curve for SN 2012cg,
though slightly overluminous at maximum brightness and with normal color
evolution (including some of the earliest SN Ia filtered photometry ever
obtained). Spectral fits to SN 2012cg reveal ions typically found in SNe Ia at
early times, with expansion velocities >14,000 km/s at 2.5 d past explosion.
Absorption from C II is detected early, as well as high-velocity components of
both Si II 6355 Ang. and Ca II. Our last spectrum (13.5 d past explosion)
resembles that of the somewhat peculiar SN Ia 1999aa. This suggests that SN
2012cg will have a slower-than-average declining light curve, which may be
surprising given the faster-than-average rising light curve.Comment: re-submitted to ApJL, 4 figures, 1 tabl
SN2012ab: A Peculiar Type IIn Supernova with Aspherical Circumstellar Material
We present photometry, spectra, and spectropolarimetry of supernova (SN)
2012ab, mostly obtained over the course of days after discovery. SN
2012ab was a Type IIn (SN IIn) event discovered near the nucleus of spiral
galaxy 2MASXJ12224762+0536247. While its light curve resembles that of SN
1998S, its spectral evolution does not. We see indications of CSM interaction
in the strong intermediate-width emission features, the high luminosity (peak
at absolute magnitude ), and the lack of broad absorption features in
the spectrum. The H emission undergoes a peculiar transition. At early
times it shows a broad blue emission wing out to km
and a truncated red wing. Then at late times (
100days) it shows a truncated blue wing and a very broad red emission wing
out to roughly km . This late-time broad red wing
probably arises in the reverse shock. Spectra also show an asymmetric
intermediate-width H component with stronger emission on the red side
at late times. The evolution of the asymmetric profiles requires a density
structure in the distant CSM that is highly aspherical. Our spectropolarimetric
data also suggest asphericity with a strong continuum polarization of % and depolarization in the H line, indicating asphericity in the
CSM at a level comparable to that in other SNe IIn. We estimate a mass-loss
rate of for km extending back at least 75yr prior to the
SN. The strong departure from axisymmetry in the CSM of SN 2012ab may suggest
that the progenitor was an eccentric binary system undergoing eruptive mass
loss.Comment: 18 pages, 12 figure
Athena\u27s Prism - A Diplomatic Strategy Role Playing Simulation for Generating Ideas and Exploring Alternatives
Intelligence analysts must clear at least three hurdles to get good product out the door: cognitive biases, social biases and self-imposed organizational impediments. Others (e.g., Gilovich, et al., Heuer, and Kahneman and Tversky), explain the cognitive processes that can help or trip us. A less well mapped set of dangers arises in the social dynamics of communicating tasking, working with other analysts, editing and customer interaction. Finally, the mere fact of a unit\u27s published record creates analytic inertia - an argument at rest tends to stay at rest and one in motion (i.e., ambiguous or uncertain) tends to stay in motion. (A variation of this includes groupthink.
Estimation of CpG Coverage in Whole Methylome Next-Generation Sequencing Studies
Background
Methylation studies are a promising complement to genetic studies of DNA sequence. However, detailed prior biological knowledge is typically lacking, so methylome-wide association studies (MWAS) will be critical to detect disease relevant sites. A cost-effective approach involves the next-generation sequencing (NGS) of single-end libraries created from samples that are enriched for methylated DNA fragments. A limitation of single-end libraries is that the fragment size distribution is not observed. This hampers several aspects of the data analysis such as the calculation of enrichment measures that are based on the number of fragments covering the CpGs. Results
We developed a non-parametric method that uses isolated CpGs to estimate sample-specific fragment size distributions from the empirical sequencing data. Through simulations we show that our method is highly accurate. While the traditional (extended) read count methods resulted in severely biased coverage estimates and introduces artificial inter-individual differences, through the use of the estimated fragment size distributions we could remove these biases almost entirely. Furthermore, we found correlations of 0.999 between coverage estimates obtained using fragment size distributions that were estimated with our method versus those that were âobservedâ in paired-end sequencing data. Conclusions
We propose a non-parametric method for estimating fragment size distributions that is highly precise and can improve the analysis of cost-effective MWAS studies that sequence single-end libraries created from samples that are enriched for methylated DNA fragments
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