Formulación de un plan estratégico sobre el clima organizacional en la empresa tabacalera Tabacos Cubanica S.A.

El plan estratégico para una empresa es una herramienta que le permite visionar mejor el futuro y proveer decisiones con cierta seguridad en base al análisis del entorno y su comportamiento para enfrentar las contingencias o crisis que se puedan generar

Efectos de la implementación de un Control Financiero en la Tienda Mundo Tecnológico IAM de la ciudad de Estelí durante el periodo del 01 de enero al 31 de diciembre de 2021

El presente trabajo investigativo es aplicado en la tienda Mundo Tecnológico IAM ubicada en la ciudad de Estelí, lo cual expande un estudio sobre el propósito de la implementación de un control financiero, con el objetivo de analizar los registros contables de la microempresa durante el período del 01 de Enero al 31 de Diciembre del 2021, el tipo de estudio del trabajo investigativo es cualitativo porque permite conocer los efectos de la implementación de dicho control, para lo cual se aplicaron técnicas de recolección de información y herramientas que ayudaron en el análisis de los procedimientos contables, por lo tanto, fue necesario realizar entrevistas, guías de observación y análisis de documentos para obtener la información necesaria, estos dirigidos al propietario y trabajadores de la entidad. En el desarrollo de los resultados se planteó como primer objetivo la descripción de la situación financiera de la Tienda Mundo Tecnológico IAM, además, se desarrollaron diferentes actividades para lograr comprender el registro de las operaciones que se ejecutan de forma diaria, como segundo objetivo se diseñó un control financiero adaptado a las necesidades que presenta la entidad, de modo que se realicen las operaciones de manera eficiente logrando el desarrollo de los efectos de la aplicación de los controles financieros, de modo que, se evidenció la funcionalidad de los mismos en la entidad, el procesamiento de la información se hace de forma eficiente contribuyendo a la generación de reportes con datos actualizados y confiables para la elaboración de los Estados Financieros

La superación posgraduada en idioma inglés de los profesionales de la salud / Post-graduate studies in English Language por health professionals

La educación de postgrado en Cuba constituye un sistema nacional. Esta idea tiene varios sentidos que es preciso aclarar. Es un sistema en tanto la educación de postgrado se rige por criterios únicos en todas las instituciones del país, donde se desenvuelve la formación científica y profesional de los egresados universitarios. Está dirigida a la capacitación de los profesionales de las diferentes instituciones y organismos del país, garantizando con ello la solución a diversos problemas que enfrentan nuestros profesionales en los lugares donde éstos se desempeñan. Ejemplo de lo anterior: se manifiesta de forma reiterada en el cumplimiento de las misiones internacionalistas que realizan nuestros médicos y demás personal de la salud en diferentes países, donde el uso del inglés para la comunicación no es una metáfora, sino una realidad palpable. Se pretende, por tanto, en el trabajo hacer algunas consideraciones acerca del papel del postgrado en idioma inglés de los profesionales de la salud en Cuba. Palabras clave: HABLA, ENSEÑANZA, EDUCACIÓN MÉDICA, CUBA. ABSTRACT Post-graduate education in Cuba constitutes a national system. This idea has several senses that are important to clarify. It is a system, since post-graduate education is ruled by single criteria in all the institutions of the country where scientific and professional formation of graduates in universities take place. It is aimed at the training of professionals from the different institutions of the country, thereby reinforcing the solution to several problems that professionals face in the different places where their activities are performed. An example of this is shown repeatedly in the completion of international missions by Cuban doctors and other health professionals, in other countries where the use of the English language to communicate is not a metaphor but a reality. The purpose of this work is to take into consideration the role of post-graduate courses in English language for health professionals in Cuba. Key words: SPEECH/, LEARNING, MEDICAL EDUCATION, CUB

EVOLUCIÓN CLÍNICA DE DEFECTOS QUIRÚRGICOS FACIALES REHABILITADOS CON MEMBRANA RICA EN FIBRINA

La membrana rica en fibrina es una novedosa herramienta terapéutica que ha revolucionado el mundo de la medicina debido a los recientes éxitos de esta terapia de la medicina regenerativa. El objetivo de la investigación estuvo encaminado a describir la evolución clínica de la membrana rica en fibrina colocada en defectos quirúrgicos faciales. Se realizó un estudio de tipo observacional, descriptivo, longitudinal y prospectivo desde febrero de 2015 a febrero de 2018 en la consulta de Cirugía Maxilofacial de la Facultad de Estomatología de la Universidad de Ciencias Médicas de Villa Clara. La aplicación de la membrana rica en fibrina permitió a la mayoría de los pacientes un postoperatorio aceptable, sin signos de dolor e inflamación. Además, el tiempo de cicatrización osciló entre 7 y 15 días para casi la totalidad de las membranas y el resultado estético fue maravilloso

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research

CK2 represents an oncology target scientifically validated. However, clinical research with inhibitors of the CK2-mediated phosphorylation event is still insufficient to recognize it as a clinically validated target. CIGB-300, an investigational peptide-based drug that targets the phosphoaceptor site, binds to a CK2 substrate array in vitro but mainly to B23/nucleophosmin in vivo. The CIGB-300 proapoptotic effect is preceded by its nucleolar localization, inhibition of the CK2-mediated phosphorylation on B23/nucleophosmin and nucleolar disassembly. Importantly, CIGB-300 shifted a protein array linked to apoptosis, ribosome biogenesis, cell proliferation, glycolisis, and cell motility in proteomic studies which helped to understand its mechanism of action. In the clinical ground, CIGB-300 has proved to be safe and well tolerated in a First-in-Human trial in women with cervical malignancies who also experienced signs of clinical benefit. In a second Phase 1 clinical trial in women with cervical cancer stage IB2/II, the MTD and DLT have been also identified in the clinical setting. Interestingly, in cervical tumors the B23/nucleophosmin protein levels were significantly reduced after CIGB-300 treatment at the nucleus compartment. In addition, expanded use of CIGB-300 in case studies has evidenced antitumor activity when administered as compassional option. Collectively, our data outline important clues on translational and clinical research from this novel peptide-based drug reinforcing its perspectives to treat cancer and paving the way to validate CK2 as a promising target in oncology.Fil: Perea, Silvio E.. Center for Genetic Engineering and Biotechnology; CubaFil: Baladron, Idania. Center for Genetic Engineering and Biotechnology; CubaFil: Garcia, Yanelda. Center for Genetic Engineering and Biotechnology; CubaFil: Perera, Yasser. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Adlin. Center for Genetic Engineering and Biotechnology; CubaFil: Soriano, Jorge L.. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Batista, Noyde. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Palau, Aley. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Hernández, Ignacio. Center for Genetic Engineering and Biotechnology; CubaFil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia, Idrian. Center for Genetic Engineering and Biotechnology; CubaFil: Gonzalez, Lidia. Center for Genetic Engineering and Biotechnology; CubaFil: Gil, Jeovanis. Center for Genetic Engineering and Biotechnology; CubaFil: Rodriguez, Arielis. Center for Genetic Engineering and Biotechnology; CubaFil: Solares, Margarita. Center for Genetic Engineering and Biotechnology; CubaFil: Santana, Agueda. Center for Genetic Engineering and Biotechnology; CubaFil: Cruz, Marisol. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Matilde. Center for Genetic Engineering and Biotechnology; CubaFil: Valenzuela, Carmen. Center for Genetic Engineering and Biotechnology; CubaFil: Reyes, Osvaldo. Center for Genetic Engineering and Biotechnology; CubaFil: López Saura, Pedro A.. Center for Genetic Engineering and Biotechnology; CubaFil: González, Carlos A.. Center for Genetic Engineering and Biotechnology; CubaFil: Diaz, Alina. Center for Genetic Engineering and Biotechnology; CubaFil: Castellanos, Lila. Center for Genetic Engineering and Biotechnology; CubaFil: Sanchez, Aniel. Center for Genetic Engineering and Biotechnology; CubaFil: Betancourt, Lazaro. Center for Genetic Engineering and Biotechnology; CubaFil: Besada, Vladimir. Center for Genetic Engineering and Biotechnology; CubaFil: González, Luis J.. Center for Genetic Engineering and Biotechnology; CubaFil: Garay, Hilda. Center for Genetic Engineering and Biotechnology; CubaFil: Gómez, Roberto. Center for Genetic Engineering and Biotechnology; CubaFil: Gomez, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perrin, Phillipe. No especifíca;Fil: Renualt, Jean Yves. No especifíca;Fil: Sigman, Hugo. No especifíca;Fil: Herrera, Luis. Center for Genetic Engineering and Biotechnology; CubaFil: Acevedo, Boris. Center for Genetic Engineering and Biotechnology; Cub

Protection of hybrid immunity against SARS-CoV-2 reinfection and severe COVID-19 during periods of Omicron variant predominance in Mexico

BackgroundWith the widespread transmission of the Omicron SARS-CoV-2 variant, reinfections have become increasingly common. Here, we explored the role of immunity, primary infection severity, and variant predominance in the risk of reinfection and severe COVID-19 during Omicron predominance in Mexico.MethodsWe analyzed reinfections in Mexico in individuals with a primary infection separated by at least 90 days from reinfection using a national surveillance registry of SARS-CoV-2 cases from March 3rd, 2020, to August 13th, 2022. Immunity-generating events included primary infection, partial or complete vaccination, and booster vaccines. Reinfections were matched by age and sex with controls with primary SARS-CoV-2 infection and negative RT-PCR or antigen test at least 90 days after primary infection to explore reinfection and severe disease risk factors. We also compared the protective efficacy of heterologous and homologous vaccine boosters against reinfection.ResultsWe detected 231,202 SARS-CoV-2 reinfections in Mexico, most occurring in unvaccinated individuals (41.55%). Over 207,623 reinfections occurred during periods of Omicron (89.8%), BA.1 (36.74%), and BA.5 (33.67%) subvariant predominance and a case-fatality rate of 0.22%. Vaccination protected against reinfection, without significant influence of the order of immunity-generating events and provided >90% protection against severe reinfections. Heterologous booster schedules were associated with ~11% and ~ 54% lower risk for reinfection and reinfection-associated severe COVID-19, respectively, modified by time-elapsed since the last immunity-generating event, when compared against complete primary schedules.ConclusionSARS-CoV-2 reinfections increased during Omicron predominance. Hybrid immunity provides protection against reinfection and associated severe COVID-19, with potential benefit from heterologous booster schedules

Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies

<p>Abstract</p> <p>Background</p> <p>Cervical cancer is now considered the second leading cause of death among women worldwide, and its incidence has reached alarming levels, especially in developing countries. Similarly, high grade squamous intraepithelial lesion (HSIL), the precursor stage for cervical cancer, represents a growing health problem among younger women as the HSIL management regimes that have been developed are not fully effective. From the etiological point of view, the presence of Human Papillomavirus (HPV) has been demonstrated to play a crucial role for developing cervical malignancies, and viral DNA has been detected in 99.7% of cervical tumors at the later stages. CIGB-300 is a novel cyclic synthetic peptide that induces apoptosis in malignant cells and elicits antitumor activity in cancer animal models. CIGB-300 impairs the Casein Kinase (CK2) phosphorylation, by targeting the substrate's phosphoaceptor domain. Based on the perspectives of CIGB-300 to treat cancer, this "first-in-human" study investigated its safety and tolerability in patients with cervical malignancies.</p> <p>Methods</p> <p>Thirty-one women with colposcopically and histologically diagnosed microinvasive or pre-invasive cervical cancer were enrolled in a dose escalating study. CIGB-300 was administered sequentially at 14, 70, 245 and 490 mg by intralesional injections during 5 consecutive days to groups of 7 – 10 patients. Toxicity was monitored daily until fifteen days after the end of treatment, when patients underwent conization. Digital colposcopy, histology, and HPV status were also evaluated.</p> <p>Results</p> <p>No maximum-tolerated dose or dose-limiting toxicity was achieved. The most frequent local events were pain, bleeding, hematoma and erythema at the injection site. The systemic adverse events were rash, facial edema, itching, hot flashes, and localized cramps. 75% of the patients experienced a significant lesion reduction at colposcopy and 19% exhibited full histological regression. HPV DNA was negative in 48% of the previously positive patients. Long term follow-up did not reveal recurrences or adverse events.</p> <p>Conclusion</p> <p>CIGB 300 was safe and well tolerated. This is the first clinical trial where a drug has been used to target the CK2 phosphoaceptor domain providing an early proof-of-principle of a possible clinical benefit.</p

IUS Y LEX: LA JORNADA DE TRABAJO COMO ELEMENTO DEL MEDIO AMBIENTE LABORAL

En el trabajo abordamos aspectos relacionados con el Medio Ambiente Laboral y realizamos un análisis doctrinal y legislativo de la jornada laboral como institución jurídica laboral que forma parte de este. Dedicamos un espacio al concepto de jornada de trabajo o jornada laboral y culminamos con la regulación actual que presenta esta institución en el ordenamiento jurídico cubano. Para finalizar reafirmamos la idea de establecer adecuados regimenes de trabajo y descanso con efectos positivos para el hombre y para el trabajo.jornada de trabajo, medio ambiente laboral

La superación posgraduada en idioma inglés de los profesionales de la salud Post-graduate studies in English Language por health professionals

La educación de postgrado en Cuba constituye un sistema nacional. Esta idea tiene varios sentidos que es preciso aclarar. Es un sistema en tanto la educación de postgrado se rige por criterios únicos en todas las instituciones del país, donde se desenvuelve la formación científica y profesional de los egresados universitarios. Está dirigida a la capacitación de los profesionales de las diferentes instituciones y organismos del país, garantizando con ello la solución a diversos problemas que enfrentan nuestros profesionales en los lugares donde éstos se desempeñan. Ejemplo de lo anterior: se manifiesta de forma reiterada en el cumplimiento de las misiones internacionalistas que realizan nuestros médicos y demás personal de la salud en diferentes países, donde el uso del inglés para la comunicación no es una metáfora, sino una realidad palpable. Se pretende, por tanto, en el trabajo hacer algunas consideraciones acerca del papel del postgrado en idioma inglés de los profesionales de la salud en Cuba.Post-graduate education in Cuba constitutes a national system. This idea has several senses that are important to clarify. It is a system, since post-graduate education is ruled by single criteria in all the institutions of the country where scientific and professional formation of graduates in universities take place. It is aimed at the training of professionals from the different institutions of the country, thereby reinforcing the solution to several problems that professionals face in the different places where their activities are performed. An example of this is shown repeatedly in the completion of international missions by Cuban doctors and other health professionals, in other countries where the use of the English language to communicate is not a metaphor but a reality. The purpose of this work is to take into consideration the role of post-graduate courses in English language for health professionals in Cuba