The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Cortometraje de ficción NEFELIBATA

Treball Final de Grau en Comunicació Audiovisual. Codi: CA0932. Curs acadèmic: 2017-2018Este trabajo de final de grado ha tenido como objetivo la realización de una pieza audiovisual, en este caso, un cortometraje titulado Nefelibata. Para ello se ha desarrollado el proyecto desde la concepción de la idea hasta su realización, siguiendo las fases habituales para la creación de un producto audiovisual: la pre-producción, la producción y la post-producción. En este trabajo se puede encontrar en primer lugar la justificación de la elección del tema y los objetivos que se pretenden alcanzar con el mismo, además de documentos que detallan el proyecto. En segundo lugar se profundizará en la trama argumental y la elaboración del cortometraje a través diferentes dossieres en los que se se encontrarán los documentos que se han requerido para la realización de la pieza audiovisual, tales como, guiones, desgloses, material ilustrado, entre otros. Seguidamente, encontraremos una memoria que relata todo el procedimiento que ha sido llevado a cabo por el equipo, además de las conclusiones y resultados obtenidos tras las finalización del proyecto. Finalmente en los anexos se ha incluido material adicional como: el making off, el vídeo de casting, la banda sonora, el script y la foto fija.This finaldegree project had an audio-visual piece as a target, in this case, a short film called Nefelibata. The work has been developed from the idea’s conception up to its accomplishment, by following the usual steps for the creation of an audio-visual product: the pre-production, the production and the post-production. In this work, in addition the documents that detail the project, you can find first of all the reason for the choice of this subject and what aimes are intended to be achieved with it. Secondly , we will go deep in the storyline and the elaboration of the short film through different dossiers, where some documents that have been required for the realization of the audiovisual piece, are found. Such as scripts, disaggregation, illustrated material, among others. Next, we will find a report that relates the entire procedure that has been carried out by the team, and also the conclusions and results obtained after the end of the project. Finally, additional material has been included in the annexes such as: the making off, the casting video, the soundtrack, the script and the still photo