Effects of a burst of formation of first-generation stars on the evolution of galaxies

First-generation (Population III) stars in the universe play an important role inearly enrichment of heavy elements in galaxies and intergalactic medium and thus affect the history of galaxies. The physical and chemical properties of primordial gas clouds are significantly different from those of present-day gas clouds observed in the nearby universe because the primordial gas clouds do not contain any heavy elements which are important coolants in the gas. Previous theoretical considerations have suggested that typical masses of the first-generation stars are between several $M_\odot$ and $\approx 10 M_\odot$ although it has been argued that the formation of very massive stars (e.g., $> 100 M_\odot$) is also likely. If stars with several $M_\odot$ are most popular ones at the epoch of galaxy formation, most stars will evolve to hot (e.g., $\gtrsim 10^5$ K), luminous ($\sim 10^4 L_\odot$) stars with gaseous and dusty envelope prior to going to die as white dwarf stars. Although the duration of this phase is short (e.g., $\sim 10^5$ yr), such evolved stars could contribute both to the ionization of gas in galaxies and to the production of a lot of dust grains if the formation of intermediate-mass stars is highly enhanced. We compare gaseous emission-line properties of such nebulae with some interesting high-redshift galaxies such asIRAS F10214+4724 and powerful radio galaxies.Comment: 25 pages, 7 figures, ApJ, in pres

Parameter Estimation and Quantitative Parametric Linkage Analysis with GENEHUNTER-QMOD

Objective: We present a parametric method for linkage analysis of quantitative phenotypes. The method provides a test for linkage as well as an estimate of different phenotype parameters. We have implemented our new method in the program GENEHUNTER-QMOD and evaluated its properties by performing simulations. Methods: The phenotype is modeled as a normally distributed variable, with a separate distribution for each genotype. Parameter estimates are obtained by maximizing the LOD score over the normal distribution parameters with a gradient-based optimization called PGRAD method. Results: The PGRAD method has lower power to detect linkage than the variance components analysis (VCA) in case of a normal distribution and small pedigrees. However, it outperforms the VCA and Haseman-Elston regression for extended pedigrees, nonrandomly ascertained data and non-normally distributed phenotypes. Here, the higher power even goes along with conservativeness, while the VCA has an inflated type I error. Parameter estimation tends to underestimate residual variances but performs better for expectation values of the phenotype distributions. Conclusion: With GENEHUNTER-QMOD, a powerful new tool is provided to explicitly model quantitative phenotypes in the context of linkage analysis. It is freely available at http://www.helmholtz-muenchen.de/genepi/downloads. Copyright (C) 2012 S. Karger AG, Base

Nonequilibrium wetting of finite samples

As a canonical model for wetting far from thermal equilibrium we study a Kardar-Parisi-Zhang interface growing on top of a hard-core substrate. Depending on the average growth velocity the model exhibits a non-equilibrium wetting transition which is characterized by an additional surface critical exponent theta. Simulating the single-step model in one spatial dimension we provide accurate numerical estimates for theta and investigate the distribution of contact points between the substrate and the interface as a function of time. Moreover, we study the influence of finite-size effects, in particular the time needed until a finite substrate is completely covered by the wetting layer for the first time.Comment: 17 pages, 8 figures, revisio

Inelastic interaction mean free path of negative pions in tungsten

The inelastic interaction mean free paths lambda of 5, 10, and 15 GeV/c pions were measured by determining the distribution of first interaction locations in a modular tungsten-scintillator ionization spectrometer. In addition to commonly used interaction signatures of a few (2-5) particles in two or three consecutive modules, a chi2 distribution is used to calculate the probability that the first interaction occurred at a specific depth in the spectrometer. This latter technique seems to be more reliable than use of the simpler criteria. No significant dependence of lambda on energy was observed. In tungsten, lambda for pions is 206 plus or minus 6 g/sq cm

Проектирование системы электроснабжения электротехнического завода

В процессе исследования произведен расчет нагрузок трансформаторного и базы в целом с применением различных методов, выбор метода расчета производился на основе исходных данных, а также осуществлен выбор оборудования и его проверка при различных режимах работы. В результате исследования была спроектирована конкретная модель электроснабжения базы по обслуживанию нефтегазодобывающего месторождения, представлена ее экономическая целесообразность и безопасность для окружающей среды.In the process of studying the calculation of the load and base as a whole with the use of various methods, the choice of the calculation method on the basis of the initial data, and also the selection of equipment and its verification under various operating modes was carried out. As a result of the research, a specific model of power supply for the oil and gas industry maintenance base, its economic feasibility and safety for the environment was designed

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Deletion of exon 9 from Cullin‐3 (CUL3, residues 403–459: CUL3Δ403–459) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt). CUL3 binds the RING protein RBX1 and various substrate adaptors to form Cullin‐RING‐ubiquitin‐ligase complexes. Bound to KLHL3, CUL3‐RBX1 ubiquitylates WNK kinases, promoting their ubiquitin‐mediated proteasomal degradation. Since WNK kinases activate Na/Cl co‐transporters to promote salt retention, CUL3 regulates blood pressure. Mutations in both KLHL3 and WNK kinases cause PHA2 by disrupting Cullin‐RING‐ligase formation. We report here that the PHA2E mutant, CUL3Δ403–459, is severely compromised in its ability to ubiquitylate WNKs, possibly due to altered structural flexibility. Instead, CUL3Δ403–459 auto‐ubiquitylates and loses interaction with two important Cullin regulators: the COP9‐signalosome and CAND1. A novel knock‐in mouse model of CUL3WT/Δ403–459 closely recapitulates the human PHA2E phenotype. These mice also show changes in the arterial pulse waveform, suggesting a vascular contribution to their hypertension not reported in previous FHHt models. These findings may explain the severity of the FHHt phenotype caused by CUL3 mutations compared to those reported in KLHL3 or WNK kinases

Silicon-organic hybrid electro-optical devices

Organic materials combined with strongly guiding silicon waveguides open the route to highly efficient electro-optical devices. Modulators based on the so-called silicon-organic hybrid (SOH) platform have only recently shown frequency responses up to 100 GHz, high-speed operation beyond 112 Gbit/s with fJ/bit power consumption. In this paper, we review the SOH platform and discuss important devices such as Mach-Zehnder and IQ-modulators based on the linear electro-optic effect. We further show liquid-crystal phase-shifters with a voltage-length product as low as V pi L = 0.06 V.mm and sub-mu W power consumption as required for slow optical switching or tuning optical filters and devices

Induced four fold anisotropy and bias in compensated NiFe/FeMn double layers

A vector spin model is used to show how frustrations within a multisublattice antiferromagnet such as FeMn can lead to four-fold magnetic anisotropies acting on an exchange coupled ferromagnetic film. Possibilities for the existence of exchange bias are examined and shown to exist for the case of weak chemical disorder at the interface in an otherwise perfect structure. A sensitive dependence on interlayer exchange is found for anisotropies acting on the ferromagnet through the exchange coupling, and we show that a wide range of anisotropies can appear even for a perfect crystalline structure with an ideally flat interface.Comment: 7 pages, 7 figure