Cameroonian Medicinal Plants: Pharmacology and Derived Natural Products

Many developing countries including Cameroon have mortality patterns that reflect high levels of infectious diseases and the risk of death during pregnancy and childbirth, in addition to cancers, cardiovascular diseases and chronic respiratory diseases that account for most deaths in the developed world. Several medicinal plants are used traditionally for their treatment. In this review, plants used in Cameroonian traditional medicine with evidence for the activities of their crude extracts and/or derived products have been discussed. A considerable number of plant extracts and isolated compounds possess significant antimicrobial, anti-parasitic including antimalarial, anti-proliferative, anti-inflammatory, anti-diabetes, and antioxidant effects. Most of the biologically active compounds belong to terpenoids, phenolics, and alkaloids. Terpenoids from Cameroonian plants showed best activities as anti-parasitic, but rather poor antimicrobial effects. The best antimicrobial, anti-proliferative, and antioxidant compounds were phenolics. In conclusion, many medicinal plants traditionally used in Cameroon to treat various ailments displayed good activities in vitro. This explains the endeavor of Cameroonian research institutes in drug discovery from indigenous medicinal plants. However, much work is still to be done to standardize methodologies and to study the mechanisms of action of isolated natural products

What Make African Happy

This paper analyses the key determinants of happiness in Africa. Using both Bayesian Model Averaging (BMA) and Weighted Average Least Squares (WALS) approaches to tackle the issue of model uncertainty on a panel of 30 African countries over the period 2006-2017, we found 14 economic, social, cultural, historical, structural and institutional factors which influence African well-bein

Review of the Chemistry and Pharmacology of 7-Methyljugulone

Background: Naphthoquinone is a class of phenolic compounds derived from naphthalene. 7-Methyljuglone (7-MJ) is a naphthoquinone also known as ramentaceone or 6-Methyl-8-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-1,4-naphthoquinone or 7-Methyl-5-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-,1,4-naphtoquinone or 7-Methyl-5-hydroxynaphthalene-1,4-dione. This compound is a biologically active naphtoquinone, with a molecular weight of 188 g/mol mostly isolated in the genus Diospyros and Euclea. Objectives: This review was aimed at providing available chemically and pharmacological data on 7-MJ. Methods: The chemical and pharmacological data were retrieved from the well-known scientific websites such as Pubmed, Google Scholar, Reaxys, Scirus, Scopus, Sciencedirect, Web-of-knowledge and Scifinder. Results: 7-MJ was reported to have a variety of pharmacological activities such as antibacterial, antifungal, anticancer, antitubercular, anti-inflammatory and antiviral activities. The hemi-synthesis of the compound have been described. Conclusions: The present review pooled out together the knowledge on 7-MJ, and can serve as the start point for future research and valorization accomplishments.Keywords: 7-methyljugulone; biosynthesis; in vitro synthesis; pharmacologyAfrican Health sciences Vol 14 No. 1 March 201

An Assessment of School Going Population Exposure Pathways to Agropesticide in the Mungo Corridor of Cameroon

Pesticide use in agricultural holdings closer to dwellings exposes the population to its noxious effects. This study is set on the premise that although pesticide seems a panacea for crop protection, it has continued to wreak havoc on farmers’ health and especially school going population who are exposed to pesticide use in nearby agroindustrial plantations in the Mungo Corridor. The study objectives are to identify students who use pesticides and why they use these toxic chemicals. In this same vein, it probes into identifying some common pesticides exposure pathways among students and the resultant effects of these toxic chemicals on them. The study employed both primary and secondary data, and key informant interviews with resource persons. Data was collected through a survey of 510 students across 10 schools in two subdivisions. Data analysis was run on Microsoft Excel 2016 and SPSS 16.0, employing descriptive (percentage indices, charts, mean, median) and inferential (Kruskal-Wallis (H-Test), Mann Whitney (U-Test), and ChiSquare test) statistics. Findings revealed that school going population is potentially exposed to pesticides via different exposure pathways, justified by the proximity of schools to agroindustrial banana plantations where pesticides are sprayed using helicopters. Also, majority of students (85%) use pesticides for various reasons with little or no knowledge on the methods of use which further broadens their exposure. A weighted analysis of data revealed that there was a significant difference between students’ education level and some hypothesized explanatory variables (p<0.05), implying that lack of information by students on how to avoid contacts with pesticides further exposes them. However, the paper concludes that receiving training in the safe use of pesticides by students and providing wind barriers in agroindustrial banana plantations to prevent spray drifts from entering into school yards and residence are key solutions to this danger

Resource rents and happiness on a global perspective: The resource curse revisited

We revisit resource curse theory by providing empirical evidence for the effects of natural resource on the subjective wellbeing. Using cross-sectional model based on a global sample of 149 countries, we highlight that resources rents tend to reduce happiness but this effect differs according to (i) the political system and the level of development, (ii) the types and the measures of natural resources and (iii) the scale of happiness. Specifically, the negative effect of natural resources on happiness tends to be amplified in developing and weak democracy countries. Furthermore, the disaggregation of natural resource rents show that while oil rents and natural gas rent have a significant negative effect, forest, coal and mineral rents do not. However, after using the quantile regression approach, we find that these effects vary at different intervals throughout the happiness distribution

What Make African Happy

This paper analyses the key determinants of happiness in Africa. Using both Bayesian Model Averaging (BMA) and Weighted Average Least Squares (WALS) approaches to tackle the issue of model uncertainty on a panel of 30 African countries over the period 2006-2017, we found 14 economic, social, cultural, historical, structural and institutional factors which influence African well-bein

Medium-Long-Term Clinical and Radiographic Outcomes of Minimally Invasive Distal Metatarsal Metaphyseal Osteotomy (DMMO) for Central Primary Metatarsalgia: Do Maestro Criteria Have a Predictive Value in the Preoperative Planning for This Percutaneous Technique?

The purpose of this prospective study was first to evaluate the safety and effectiveness of Minimally Invasive Distal Metatarsal Metaphyseal Osteotomy (DMMO) in treating central metatarsalgia, identifying possible contraindications. The second objective was to verify the potential of DMMO to restore a harmonious forefoot morphotype according to Maestro criteria. Methods. A consecutive series of patients with metatarsalgia was consecutively enrolled and treated by DMMO. According to Maestro criteria, preoperative planning was carried out by both clinical and radiological assessment. Patient demographic data, AOFAS scores, 17-FFI, MOXFQ, SF-36, VAS, and complications were recorded. Maestro parameters, relative morphotypes, and bone callus formation were assessed. Statistical analysis was carried out (p<0.05). Results. Ninety-three patients (93 feet) with a mean age of 62.4 (31-87) years were evaluated. At mean follow-up of 58.7 (36-96) months, all of the clinical scores improved significantly (p<0.0001). Most of the osteotomies (76.3%) had healed by 3-month follow-up, while ideal harmonious morphotype was restored only in a few feet (3.2%). Clinical and radiological outcomes were not different based on principal demographic parameters. Long-term complications were recorded in 12 cases (12.9%). Conclusion. DMMO is a safe and effective method for the treatment of metatarsalgia. Although Maestro criteria were useful to calculate the metatarsal bones to be shortened and a significant clinical improvement of all scores was achieved, the ideal harmonious morphotype was restored only in a few feet. Hence, our data show that Maestro criteria did not have a predictive value in clinical outcomes of DMM

Urinary tract infections, bacterial resistance and immunological status: a cross sectional study in pregnant and non-pregnant women at Mbouda Ad-Lucem Hospital

Background: Urinary tract infections (UTI) are frequently encountered medical complications of pregnancy.Objective: This study was aimed at analyzing the bacterial resistance in urogenital tract as well as the immunological profile amongst pregnant and non-pregnant women at Mbouda Ad-Lucem Hospital, Western Region of Cameroon.Methods: A cross-sectional study was carried out from December 2015 to May 2016 at Mbouda Ad-Lucem hospital on 104 pregnant women and 24 non-pregnant women. The midstream urine from participants was analysed for the presence, isolation and identification of the uro-pathogens, using selective and specific bacterial culture media. An antibiotic susceptibility tests was carried out using disk diffusion method. Blood samples were collected for C-reactive protein (CRP) dosage, CD4 and CD8 lymphocytes count.Results: Out of 128 participants in this study, a high prevalence of uro-pathogens and resistance strains was observed. The most prevalent urinary tract pathogens were Staphylococcus sp. with 45% and 38.89% respectively in pregnant and non-pregnant women. Staphylococcus sp. showed resistance to Amoxicillin (AMO; 55.56%) and Chloramphenicol (CHL; 100%) respectively in pregnant and non-pregnant women. Pregnant women had a significantly high average of granulocytes (p=0.009), monocytes (P=0.001), high ratio of CD4/CD8 (p&lt; 0.0001) and significantly low CD8 lymphocytes (p&lt; 0.0001) average compared to non-pregnant women.Conclusion: This study outlines high prevalence of Staphylococcus sp as the main urinary tract infectious pathogen in women at Mbouda Ad-Lucem hospital. It prevalence was accompanied with resistance to the routine antibiotics treatment, and a pro- nounced lymphocytosis and monocytosis.Keywords: Antibiotic resistance; bacterial profile; immunological status; Mbouda; multidrug-resistance; pregnancy