Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma

The aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP—ferric reducing ability of plasma, and reduced glutathione—GSH) and enzymatic (glutathione peroxidase—GPx, catalase—CAT, and GPx/CAT ratio) activity in the plasma of healthy male Wistar rats. Three vanadium complexes: [VO(bpy)2]SO4·2H2O, [VO(4,4′Me2bpy)2]SO4·2H2O, and Na[VO(O2)2(bpy)]·8H2O are administered by gavage during 5 weeks in two different diets such as control (C) and high fatty (F) diets. Changes of biochemical and antioxidants parameters are measured in plasma. All three vanadium complexes statistically decrease the body mass growth in comparison to the control and fatty diet. In plasma GSH was statistically increased in all vanadium complexes-treated rats from control and fatty group in comparison to only control group. Calculated GPX/CAT ratio was the highest in the control group in comparison to others

Guzy endokrynne żołądka i dwunastnicy z uwzględnieniem gastrinoma (zasady postępowania rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

The neuroendocrine tumors of the stomach and duodenum constitute only minority of neoplasms in this localisation. However due to their clinical behaviour and/or hormonal syndromes they pose diagnostic and therapeutic challenge. They display distinct phenotypes, regarding their pathogenesis, pathology and clinical course. Herein we present Polish guidelines for biochemical, pathological and localisation diagnosis, and discuss therapeutic approaches, considering endoscopic and surgical treatment, pharmacological and radionuclide therapy. Pol J Endocrinol 2008; 59 (1): 57-67Guzy neuroendokrynne (NET) żołądka i dwunastnicy stanowią wprawdzie tylko kilka procent wszystkich nowotworów tych narządów, jednak ze względu na specyfikę tego rodzaju zmian, stanowią one interdyscyplinarny problem diagnostyczno-terapeutyczny. W zależności od fenotypów, różnią się one patogenezą, obrazem klinicznym i histopatologicznym. W niniejszej pracy przedstawiono wytyczne grupy ekspertów Polskiej Sieci Guzów Neuroendokrynnych dotyczące zasad postępowania diagnostycznego, z uwzględnieniem diagnostyki biochemicznej, histopatologicznej oraz lokalizacyjnej, a także zasad postępowania terapeutycznego, w którym uwzględniono leczenie endoskopowe i chirurgiczne, omówiono możliwości leczenia farmakologicznego oraz radioizotopowego. Endokrynol Pol 2008; 59 (1): 57-6

Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus -- the "D-shuttle" project --

Twelve high schools in Japan (of which six are in Fukushima Prefecture), four in France, eight in Poland and two in Belarus cooperated in the measurement and comparison of individual external doses in 2014. In total 216 high-school students and teachers participated in the study. Each participant wore an electronic personal dosimeter "D-shuttle" for two weeks, and kept a journal of his/her whereabouts and activities. The distributions of annual external doses estimated for each region overlap with each other, demonstrating that the personal external individual doses in locations where residence is currently allowed in Fukushima Prefecture and in Belarus are well within the range of estimated annual doses due to the background radiation level of other regions/countries

Place of vitamin D in everyday clinical practice — an interdisciplinary expert opinion

Niedobory witaminy D są jednymi z najczęściej występujących niedoborów w populacji ogólnej. Ich konsekwencje obejmują wiele układów, w tym krwionośny, kostno-stawowy, endokrynny i inne. Korygowanie niedoborów witaminy D może mieć niezwykle istotne znacznie w leczeniu wielu chorób i powinno być przedmiotem zainteresowania lekarzy wielu specjalności. Poniżej przedstawiono interdyscyplinarne stanowisko ekspertów dotyczące znaczenia witaminy D w patogenezie wielu jednostek chorobowych oraz zasadności uzupełniania jej niedoborów, bazujące na najnowszych doniesieniach i publikacjach.Vitamin D deficiency are among the most common deficiencies in the general population. Their consequences include many systems, including the circulatory, muscle and joints, endocrine and others. Correcting the deficiency of vitamin D can have extremely crucial impact on many diseases and should be of interest to doctors of many specialties. The following is a multi-disciplinary expert opinion on the significance of vitamin D in the pathogenesis of a number of diseases and their reasonableness supplement its deficiencies, based on the latest reports and publications

Neuroendocrine neoplasms of the small intestine and the appendix - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours).

This study presents the revised Polish guidelines regarding the management of patients suffering from neuroendocrine neoplasms (NENs) of the small intestine and appendix. The small intestine, especially the ileum, is the most common location for these neoplasms. Most are well differentiated and slow growing. Their symptoms may be atypical, which can result in delayed or accidental diagnosis. Appendicitis is usually the first manifestation of NEN in this location. Typical symptoms of carcinoid syndrome occur in approximately 20-30% of patients suffering from small intestinal NENs with distant metastases. The main cause of death in patients with carcinoid syndrome is carcinoid heart disease. The most useful laboratory test is the determination of chromogranin A, while concentration of 5-hydroxyindoleacetic acid is helpful in the diagnostics of carcinoid syndrome. For visualisation, ultrasound, computed tomography, magnetic resonance imaging, colonoscopy, video capsule endoscopy, double-balloon enteroscopy, and somatostatin receptor scintigraphy may be used. A detailed his-tological report is crucial for the proper diagnostics and therapy of NENs of the small intestine and appendix. The treatment of choice is surgical management, either radical or palliative. The pharmacological treatment of the hormonally active and non-active small intestinal NENs as well as NENs of the appendix is based on long-acting somatostatin analogues. In patients with generalised NENs of the small intestine in progress during the SSA treatment, with good expression of somatostatin receptors, the first-line treatment should be radio-isotope therapy, while targeted therapies, such as everolimus, should be considered afterwards. When the above therapies are exhausted, in certain cases chemotherapy may be considered