205 research outputs found

    Experimental research upon the absorption of phenol by the skin

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    The freedom of the mind for God: reflexivity and spiritual exercises in Thomas Aquinas

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    Thesis advisor: Stephen F. BrownThe study of Thomas Aquinas generally focuses on theological questions in his work, and ignores certain aspects of what might be called his "spiritual life." Though there are exceptions to this rule, there are numerous themes in the writings of Thomas Aquinas which have not been given their due. In light of this fact, this dissertation seeks to provide an extended treatment of two components of the work of Thomas Aquinas which receive little attention: the role of spiritual exercises in his writing, and the form of reflexivity--one's understanding of and relation to one's self--he recommends. As a way of approaching these issues, I draw from the work of two historical philosophers, Pierre Hadot and Michel Foucault, using the methodological questions they employ in their writings on the classical world. Both Hadot and Foucault argued that there was something different about the way philosophy was accomplished in the antique world, something which was lost as philosophy shifted in the modern period. Hadot's work focuses, in particular, on the use of spiritual exercises in the formation of the person--that is, how a person becomes the ideal form they ought to be. Foucault, on the other hand, focused on the alternative form of reflexivity as found in the work of classical philosophers, and used it for fruitful comparison and critique of the contemporary forms of reflexivity found in the modern world. Both of these thinkers, however, never included in their study the medieval period, or at least not in an extended and meaningful way. Their questions, however, are particularly relevant to the work of Thomas Aquinas, as he offers both an extended treatment of spiritual exercises, as well as a form of reflexivity similar in many ways to classical forms. As a way of highlighting these two topics in Thomas Aquinas, I first provide an overview of the work of Pierre Hadot and Michel Foucault as it relates to these topics. I then move onto a discussion of the current state of scholarship on "spirituality" in Thomas Aquinas, and suggest the ways in which this dissertation can improve on this current state. In the subsequent chapters, I begin a discussion of the concept of virtue as found in Thomas Aquinas, and its relation to both spiritual exercises and reflexivity, the description of which in Thomas forms the basis for the next two chapters. Finally, I turn to an in depth application of these methodological questions by turning to two different works of Thomas; first, I turn to his De perfectione spiritualis vitae, a short and rarely read work in which Thomas explains the practices which accompany the formation of a person in charity. Second, I turn to the Summa Theologiae and the cardinal virtues, drawing attention to the presence of spiritual exercises in a work typically treated as merely expositional.Thesis (PhD) — Boston College, 2014.Submitted to: Boston College. Graduate School of Arts and Sciences.Discipline: Theology

    The relationship between personality and biographical factors in absenteeism

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    This research deals with personality and biographical factors in absenteeism. The literature review looks at personality traits and absenteeism. The following question must then be asked: Can the construct ”personality” be analysed and described within the context of the work environment, and can the relationship between personality, biographical factors and absenteeism be studied empirically. The empirical study focuses on measuring the relationship between personality and absenteeism. The construct ”personality” is presented within the dimensional or trait perspective. The empirical investigation is presented within the functionalistic paradigm (quantitative approach). The chosen measuring instrument, namely, the Sixteen Personality Factor Questionnaire (16 PF SA 92) was administered by means of a random sample to 72 Aviation Security Officers. The reliability of the Sixteen Personality Factor Questionnaire was determined using the Cronbach Alpha coefficient method. To determine if personality is a predictor of absenteeism, stepwise regression analysis was done. The results indicate that the degree (category) of absenteeism is associated only with marital status and number of dependants.Industrial and Organisational PsychologyM. Comm. (Industrial Psychology

    Antibiotic dosing in the 'at risk' critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients

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    Background: Critical illness, mediated by trauma or sepsis, can lead to physiological changes that alter the pharmacokinetics of antibiotics and may result in sub-therapeutic concentrations at the sites of infection. The first aim of this project is to identify the clinical characteristics of critically ill patients with significant trauma that have been recently admitted to ICU that may predict the dosing requirements for the antibiotic, cefazolin. The second aim of this is to identify the clinical characteristics of critically ill patients with sepsis that may predict the dosing requirements for the combination antibiotic, piperacillin-tazobactam

    Abiotically-induced plant morphological changes and host-range expansion in quarantine evaluations of candidate weed biocontrol agents : the case study Conchyloctenia hybrida (Coleoptera: Chrysomelidae)

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    Plant morphological changes mediated by growth conditions are linked to changes in host preference of herbivores. Understanding how these morphological changes influence herbivore feeding is critical in the interpretation of results of host evaluation of candidate weed biocontrol agents in quarantine and improvement of the evaluation system. We determined the effect of plant growth conditions on leaf trichomes and host choice of Conchyloctenia hybrida Boheman, an insect adapted to the removal of trichomes before feeding. The study included four Solanum species: Solanum lichtensteinii Willdenow (natural host of C. hybrida), Solanum mauritianum Scopoli, Solanum melongena L., and Solanum tuberosum L.. Plants were grown in either full sun, shade, a glasshouse, or in a growth-chamber. Plants grown in full sun had a higher leaf trichome density than those in shade or controlled environments. S. mauritianum had the highest trichome density and thickness of trichome layer. In a multiple-choice test using excised leaves, feeding by C. hybrida was higher on Solanum plants grown in the controlled environment as compared with full sun. Trichome removal from leaf surfaces of plants grown in full sun, using adhesive tape, was effective for S. lichtensteinii, S. mauritianum, and S. melongena, but not S. tuberosum. Leaf consumption by C. hybrida increased significantly where manual trichome removal using adhesive tape was effective. Structurally, leaves of S. tuberosum have simple trichomes with basal cells sunken into the mesophyll tissue. When using forceps to remove trichomes of S. tuberosum, mesophyll and vascular tissue remained attached to the trichomes. Generally, the type, density, and mat-thickness of leaf trichomes determined feeding by C. hybrida, but varied with plant species and growth conditions.The South African National Working for Water Programme of the Department of Water Affairshttp://www.entsoc.orgam201

    Nano-ADEPT Aeroloads Wind Tunnel Test

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    A wind tunnel test of the Adaptable Deployable Entry and Placement Technology (ADEPT) was conducted in April 2015 at the US Army's 7 by10 Foot Wind Tunnel located at NASA Ames Research Center. Key geometric features of the fabric test article were a 0.7 meter deployed base diameter, a 70 degree half-angle forebody cone angle, eight ribs, and a nose-to-base radius ratio of 0.7. The primary objective of this wind tunnel test was to obtain static deflected shape and pressure distributions while varying pretension at dynamic pressures and angles of attack relevant to entry conditions at Earth, Mars, and Venus. Other objectives included obtaining aerodynamic force and moment data and determining the presence and magnitude of any dynamic aeroelastic behavior (buzz/flutter) in the fabric trailing edge. All instrumentation systems worked as planned and a rich data set was obtained. This paper describes the test articles, instrumentation systems, data products, and test results. Four notable conclusions are drawn. First, test data support adopting a pre-tension lower bound of 10 foot pounds per inch for Nano-ADEPT mission applications in order to minimize the impact of static deflection. Second, test results indicate that the fabric conditioning process needs to be reevaluated. Third, no flutter/buzz of the fabric was observed for any test condition and should also not occur at hypersonic speeds. Fourth, translating one of the gores caused ADEPT to generate lift without the need for a center of gravity offset. At hypersonic speeds, the lift generated by actuating ADEPT gores could be used for vehicle control

    System Level Aerothermal Testing for the Adaptive Deployable Entry and Placement Technology (ADEPT)

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    The Adaptive Deployable Entry and Placement Technology (ADEPT), a mechanically deployable entry vehicle technology, has been under development at NASA since 2011. As part of the technical maturation of ADEPT, designs capable of delivering small payloads (10 kg) are being considered to rapidly mature sub 1 m deployed diameter designs. The unique capability of ADEPT for small payloads comes from its ability to stow within a slender volume and deploy to achieve a mass efficient drag surface with a high heat rate capability. The low ballistic coefficient results in entry heating and mechanical loads that can be met by a revolutionary three-dimensionally woven carbon fabric supported by a deployable skeleton structure. This carbon fabric has test proven capability as both primary structure and payload thermal protection system. In order to rapidly advance ADEPTs technical maturation, the project is developing test methods that enable thermostructural design requirement verification of ADEPT designs at the system level using ground test facilities. Results from these tests are also relevant to larger class missions and help us define areas of focused component level testing in order to mature material and thermal response design codes. The ability to ground test sub 1 m diameter ADEPT configurations at or near full-scale provides significant value to the rapid maturation of this class of deployable entry vehicles. This paper will summarize arc jet test results, highlight design challenges, provide a summary of lessons learned and discuss future test approaches based upon this methodology

    Comparing Patch vs Pen Bolus Insulin Delivery in Type 2 Diabetes Using Continuous Glucose Monitoring Metrics and Profiles

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    OBJECTIVE: CeQur Simplicity™ (CeQur, Marlborough, MA) is a 3-day insulin delivery patch designed to meet mealtime insulin requirements. A recently reported 48-week, randomized, multicenter, interventional trial compared efficacy, safety and self-reported outcomes in 278 adults with type 2 diabetes (T2D) on basal insulin therapy who initiated and managed mealtime insulin therapy with a patch pump versus insulin pen. We assessed changes in key glycemic metrics among a subset of patients who wore a continuous glucose monitoring (CGM) device. METHODS: Study participants (patch, n = 49; pen, n = 48) wore a CGM device in masked setting during the baseline period and prior to week 24. Glycemic control was assessed using international consensus guidelines for percentage of Time In Range (%TIR: \u3e70% at 70-180 mg/dL), Time Below Range (%TBR: \u3c4% at \u3c70 mg/dL; \u3c1% at \u3c54 mg/dL), and Time Above Range (%TAR: \u3c25% at \u3e180 mg/dL; \u3c5% at \u3e250 mg/dL). RESULTS: Both the patch and pen groups achieved recommended targets in %TIR (74.1% ± 18.7%, 75.2 ± 16.1%, respectively) and marked reductions in %TAR \u3e180 mg/dL (21.1% ± 19.9%, 19.7% ± 17.5%, respectively) but with increased %TBR \u3c70 mg/dL (4.7% ± 5.2%, 5.1 ± 5.8, respectively), all P \u3c .0001. No significant between-group differences in glycemic improvements or adverse events were observed. CONCLUSIONS: CGM confirmed that the patch or pen can be used to safely initiate and optimize basal-bolus therapy using a simple insulin adjustment algorithm with SMBG. Preference data suggest that use of the patch vs pen may enhance treatment adherence

    Evaluation of cardiorespiratory, blood gas, and lactate values during extended immobilization of white rhinoceros (Ceratotherium simum)

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    Ten white rhinoceros (Ceratotherium simum) were immobilized for a total of 13 procedures in holding facilities in Kruger National Park using etorphine, azaperone, and hyaluronidase to assess the effect of extended immobilization on serial cardiorespiratory, blood gas, and lactate values. Butorphanol was administered intravenously following initial blood collection and physiologic assessment (t¼0). Respiratory and cardiovascular parameters, body temperature, and arterial blood gases were monitored at 10-min intervals for a total of 100 min. Initial parameters at the time of recumbency revealed severe hypoxemia, hypercapnia, tachycardia, an increased alveolar-arterial (A-a) gradient, and mildly elevated lactate levels. At 10 min and 20 min, there were significant (P , 0.05) changes in the following physiologic parameters: heart rate decreased [96 and 80 beats/min, respectively, vs. 120 beats/min], arterial partial pressure of oxygen (PaO2) increased [48 and 45 mm Hg, respectively vs. 30 mm Hg], arterial hemoglobin oxygen saturation increased [79% and 74%, respectively, vs. 47%], A-a gradient decreased [29.13 and 30.00 mm Hg, respectively, vs. 49.19 mm Hg], and respiratory rate decreased [5 and 5 breaths/min vs. 7 breaths/min]. Blood lactate levels also decreased from 2.54 mM/L to 1.50 and 0.89 mM/L, respectively. Despite initial improvements in blood oxygen levels at t ¼ 10 and 20 min, the rhinoceros remained severely hypoxemic for the remainder of the procedure (median PaO2 ¼ 50.5 mm Hg, 95% confidence interval, 43.8–58.1). Median values for respiratory rate (5 breaths/min) and arterial partial pressure of carbon dioxide (PaCO2; 68.5 mm Hg) did not change significantly for the remaining 80 min. Median lactate, base excess, bicarbonate, and pH values improved between 20 and 100 min despite the persistent hypercapnia, indicating that the animals adequately compensated for respiratory and lactic acidosis. White rhinoceros were immobilized for 100 min with no negative effects, a desirable outcome if procedures require extended chemical immobilization without oxygen supplementation.South African National Parkshttp://zoowildlifejournal.com/loi/zamdam201
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