Kapasitas Dinas Sosial Dalam Penanggulangan Bencana Erupsi Gunung Sinabung Melalui Pendistribusian Jaminan Hidup Dan Isian Hunian Tetap Masyarakat Desa Berastepu

This study aims to find out and describe how the capacity of the Social Service in overcoming the eruption of Mount Sinabung through the distribution of life insurance and the filling of permanent housing for the people of Berastepu village. The method used is a descriptive method with a qualitative approach through data collection such as interviews, observations, documentation, and literature studies. The results of research in the field, researchers found that the capacity of the Social Service in disaster management of the Mount Sinabung eruption through the distribution of life insurance and the filling of permanent housing for the berastepu village community has not been maximized. The Social Service Office has distributed assistance to the people of Berastepu Village, but there are still problems seen from human resource indicators that have not been maximized where the employee's educational background is not in accordance with the placement of positions, then facilities and infrastructure, especially work rooms that have not provided comfort for employees, and organizational management indicators, especially information collection, have not been maximized where there is a lag in some community data so that  resulting in late distribution of aid

Koordinasi Pemerintah Dalam Program Hibah Air Minum Untuk Masyarakat Berpenghasilan Rendah Di Kota Pematang Siantar

The drinking water grant program is an effort to accelerate the addition of new house connections (SR) through the application of output-based or measured performance.  The drinking water grant program is intended as an additional fund for the Provincial Government or Regency/City Government so that they can carry out their roles and responsibilities in the provision of drinking water services.  This study aims to describe the implementation of the coordination of the drinking water grant program between agencies authorized to regulate this matter.  The program's target is Low-Income Communities (MBR) in Pematangsiantar City. This study uses a descriptive method with a qualitative approach where the data collection technique uses observation, interview and documentation methods.  The data were analyzed through data reduction, data presentation, data triangulation and drawing conclusions.  Based on this study related to the direct relationship variable, it was found that there was no evaluation and projection process in program implementation.  Based on the Continuity variable, it was found that the target of installing one hundred percent clean water connections that had been targeted earlier was not achieved.  The dynamism variable found that the Project Implementation Unit officials had not been able to provide sufficient funds for the construction of the distribution pipeline.  The supervised leadership variable found that there was still a sectoral ego so that the coordination that was built did not go well

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Objective Primary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic contribution to the severity and progression of PSC. The aim of this study is to identify genetic variants associated with PSC disease progression and development of complications. Design We collected standardised PSC subphenotypes in a large cohort of 3402 patients with PSC. After quality control, we combined 130 422 single nucleotide polymorphisms of all patients-obtained using the Illumina immunochip-with their disease subphenotypes. Using logistic regression and Cox proportional hazards models, we identified genetic variants associated with binary and time-to-event PSC subphenotypes. Results We identified genetic variant rs853974 to be associated with liver transplant-free survival (p=6.07x10(-9)). Kaplan-Meier survival analysis showed a 50.9% (95% CI 41.5% to 59.5%) transplant-free survival for homozygous AA allele carriers of rs853974 compared with 72.8% (95% CI 69.6% to 75.7%) for GG carriers at 10 years after PSC diagnosis. For the candidate gene in the region, RSPO3, we demonstrated expression in key liver-resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells. Conclusion We present a large international PSC cohort, and report genetic loci associated with PSC disease progression. For liver transplant-free survival, we identified a genome-wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver-resident effector cells. This warrants further assessments of the role of this potential key PSC modifier gene.Peer reviewe

In situ evidence for the association of total coliforms and escherichia coli with suspended inorganic particles in an Australian reservoir

The results of a field experiment that investigated the in situ association of total coliforms (TC) and E. coli (EC) with suspended inorganic particles in a drinking water reservoir are presented. The experimental program measured TC and EC at various locations and at multiple depths in a medium sized Australian reservoir subject to continuous inflow forcing. Particle concentrations and size distributions were measured using a LISST (Laser In Situ Scattering Transmissometer) profiler. Correlations between the particle measurements and the bacteria were calculated to provide in situ evidence for the association of TC and EC with suspended inorganic particles. Both TC and EC correlated most strongly with fine particles between 3.2 and 4.5 μm. Development of a simple Lagrangian model of the inflow for particles and microbes additionally provided insight into the relative roles of dilution, sedimentation, and inactivation for the bacteria. The model results and the correlations support the theory that high association with the small particles was due to their high number concentration and the effective surface area available for attachment. It was also evident that the majority of bacteria (>80%) were physically associated with the suspended particles and allowed a quantitative estimate of the net sedimentation rate. Bacterial attachment and the concomitant increase in settling should be considered when modeling bacterial dynamics, during design of monitoring programs and when implementing pathogen risk management strategies.Matthew R. Hipsey, Justin D.Brookes, Rudi H.Regel, Jason P. Antenucci and Michael D. Burc

DNA methylation-based classification of central nervous system tumours

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challengingwith substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution