Specifics of geological composition, geochemistry and geochronology of rocks from the Kresty alkaline-ultrabasic massif (Maimecha-Kotui province, Polar Siberia)

In this work, we demonstrate new data that allows us to accurate geochronological ranges of formation of the Kresty alkaline-ultrabasic massif, which is considered to be a satellite of the Gulinian giant pluton. We also interpreted geological, geochemical and isotope-geochemical data obtained earlier for major varieties of this volcanic-plutonic association taking into account new geochronological results, as well as considered new aspects/information on matter source of alkaline-ultrabasic massifs from this province. One of the main aspects is interaction of Siberian super plume matter with hosting substrate of Siberian craton continental crust

Эпидемиология генерализованной менингококковой инфекции в Новосибирской области (1992–2015 гг.)

Aim: To study the epidemiological patterns of invasive meningococcal disease in Novosibirsk region within a time period from 1992 to 2015.Methods: retrospective comparative epidemiological analysis.Results: During the analyzed period the annual incidence rate of invasive meningococcal disease was higher than average annual incidence rate in Russian Federation. Totally1690 cases were registered, average incidence rate for the period 2000–2015 was 2,2/100,000 exceeding the neighbor regions. The incidence had a tendency to continually decline and is characterized by the cyclical fluctuations with period of 4-7 years. Majority of cases occurred in children < 14 years, varying from 77,3% in 2001 to 57,8% in 2008. The highest incidence was registered in children <12 month reaching 124/100,000 of population in 2003. The increase of mortality correlated with the decrease of incidence, average mortality for period 1992–2015 was 11,4%. In etiologic structure serogroup B is predominant – 40,9%, serogrup A – 20,6%, serogrup C – 14,7%. The distinctiveness of epidemiology is cyclic dynamics with the periods of predominance of serogroup A (up to 48% in 2014). In serum analysis performed 2012 45% of probes were positive for serogroup A what demonstrates circulation of this serogoup among population.Conclusion: High incidence among children <14 years and especially among children <12 month in emerging risk of the forthcoming rise in incidence of meningococcal disease and insufficient surveillance provide need in activation of tactics of specific immuneprophylactics. Цель: изучение эпидемиологических закономерностей генерализованной менингококковой инфекции в Новосибирской области за 1992–2015 гг.Материалы и методы: ретроспективный сравнительный эпидемиологический анализ.Результаты: за анализируемый период показатели заболеваемости ГФМИ стабильно превышали показатели по Российской Федерации. Всего было зарегистрировано 1690 случаев заболевания, средний многолетний показатель за 2000–2015 гг. составил 2,2, что выше показателей пограничных регионов. Заболеваемость имеет поступательную тенденцию к снижению и характеризуется циклическими колебаниями с периодами в 4–7 лет. Доля детей до 14 лет колебалась от 77,3% в 2001 г. до 57,8% в 2008 г. Наиболее высокие показатели заболеваемости были зарегистрированы среди детей первого года жизни, до 124 на 100 тыс. населения в 2003 г. Рост летальности коррелировал со снижением заболеваемости, летальность за 1992–2015 гг. составила 11,4%. В этиологической структуре преобладали менингококки серогруппы В – 40,9%; серогруппа А – 20,6%; серогруппа С – 14,7%. Отличительной особенностью является циклическая динамика серотипового пейзажа с периодическим преобладанием менингококков группы А (до 48% в 2014 г). Анализ сывороток, проведенный в 2012 г., выявил 45% положительных проб к менингококку группы А, что свидетельствует о циркуляции этой группы среди населения.Заключение: высокие показатели заболеваемости детей до 14 лет и, прежде всего, детей первых 2 лет жизни в условиях риска предстоящего подъема заболеваемости МИ и недостаточного мониторирования эпидемиологической ситуации диктуют необходимость активации тактики специфической иммунопрофилактики

Clinical researches of a specialized sports nutrition product “Hemosport” for the regulation of hemoglobin levels in adolescent girls who are professionally involved in sports

The aim of the research was a clinical assessment of the effectiveness of the developed specialized sports nutrition product for regulating the level of hemoglobin in adolescent girls professionally involved in sports.Materials and methods: 23 girls — athletes of various sports specialization were researched during a training camp. The athletes were determined by the clinical parameters of blood, its general analysis and biochemical parameters, then the physical endurance and performance were assessed.Results: the developed product “Hemosport” demonstrated efficiency in most of the researched parameters in the main group compared with the control. The positive dynamics of most of the researched indicators revealed a general tendency to improve the state of vital organs and systems of the body of athletes of the main group, to increase their adaptive capabilities and vegetative balance.Conclusions: clinical studies of the specialized product “Hemosport” allow it to be recommended in the practice of sports nutrition for adolescent girls of 12–17 years old who are professionally involved in sports to compensate for iron deficiency nutritional deficiencies specific for this group of athletes, as well as to increase the efficiency and effectiveness of their training

A clinical case of a combination of Covid 19 and bronchiolitis caused by respiratory syncytial virus in a child

The aim of the study - to describe a clinical case of a combination of a new coronavirus infection caused by COVID19 and bronchiolitis caused by respiratory syncytial virus in a childЦель исследования - описание клинического случая сочетания у ребенка новой коронавирусной инфекции, вызванной COVID19 и бронхиолита, вызванного респираторно-синцитиальным вирусо

Subjective assessment of the tolerability of the vaccine against the new coronavirus infection Covid-19

The aim of the study - to evaluate the subjective opinion of respondents about the tolerability of vaccines against the new coronavirus infection COVID-19 by the number and severity of local and systemic reactions of the bodyЦель исследования - оценить субъективное мнение респондентов о переносимости вакцин против новой коронавирусной инфекции COVID-19 по числу и выраженности местных и системных реакций организм

Attitude of doctors of different ages and specialties to vaccination. their awareness in this issue

The article presents an analysis of the results of a questionnaire survey of existing doctors of medical institutions in the city of Yekaterinburg and the Sverdlovsk region on vaccination. The level of knowledge of the main documents related to vaccination was analyzed at the subjective and objective levels. It was revealed that the subjective assessment of their own knowledge among a significant part of the respondents does not coincide with the real ideas about vaccination. The similarities and differences in the self-assessment of knowledge and attitudes towards vaccination of doctors of various ages and specialties are considered.В статье представлен анализ результатов анкетирования действующих врачей лечебно-профилактических учреждений города Екатеринбург и Свердловской области о вакцинопрофилактике. Проанализирован уровень знания основных документов, касающихся вакцинации, на субъективном и объективном уровнях. Выявлено, что субъективная оценка собственных знаний у значительной части респондентов не совпадает с реальными представлениями о вакцинации. Рассмотрены сходства и различия в самооценке знаний и отношения к вакцинации врачей различных возрастов и специальностей

A clinical case of rupture of the spleen in infectious mononucleosis

Тhe aim of the study – to demonstrate a clinical case of an extremely rare complication in infectious mononucleosisЦель исследования – демонстрация клинического случая крайне редкого осложнения при инфекционном мононуклеоз

Comparative characteristics of medium-heavy forms of noravirus and rotavirus gastroenteritis in children

The article presents the results of a comparative clinical and laboratory analysis of noravirus and rotavirus gastroenteritis. The relationship between the degree of dehydration identified by clinical signs and its laboratory manifestations is analyzed. It has been established that clinical and laboratory signs of dehydration are more severe in patients with rotavirus infection, however, the possibility of acute renal failure due to dehydration is higher in patients with noravirus gastroenteritis.В статье представлены результаты сравнительного клинико-лабораторного анализа норовирусного и ротавирусного гастроэнтерита.Проанализирована связь между степенью дегидратации, выявленной по клиническим признакам, и её лабораторными проявлениями. Установлено, что клинические и лабораторные признаки дегидратации более выражены у пациентов с ротавирусной инфекцией, однако возможность возникновения острой почечной недостаточности на фоне дегидратации выше у пациентов с норовирусным гастроэнтерито

Clinical evaluation of effectiveness of new product of specialized sports nutrition for correction of psychophysiological state and neuromuscular transmission in highly qualified athletes

The purpose of the study is to determine the effectiveness of the specialized product Fit Tonus for correcting the psychophysiological state and neuromuscular transmission in highly qualified athletes.Materials and methods: the objects of research were: specialized product of sports nutrition for correcting the psychophysiological state and neuromuscular transmission Fit Tonus; 21 male martial arts athletes aged 14 to 25 years. The researches were carried out in accordance with official and conventional techniques. Body temperature, breathing rate, blood pressure level, heart rate was determined, heart rate variability, ECG, external breathing, O2 intake, total urine test, clinical blood test, biochemical blood indices were evaluated, water sectors of the body, body skinny weight, body fat weight were determined. Full-function cardiopulmonary analysis was performed using the Meta Lyzer 3B inpatient cardio-respiratory loading diagnostic system (Cortex Medical, Germany). Maximum oxygen consumption was determined by a Cosomed metabolograph (Italy). Biochemical parameters (bilirubin, ACT, ALT, urea, uric acid, glucose, cholesterol, HGT, amylase, alkaline phosphatase, creatinine) were examined on a Humalyzer biochemical analyzer. Water sectors of the body, the value of skinny body weight and fat body weight were determined on an analyzer for assessing the balance of water sectors of the body (Medass, Russia).Results: in the analysis of biochemical blood values, the blood levels of indicator enzymes and their isoforms were normalized in a short time, despite high training loads. This fact reflects the adaptation of the athlete’s body to high-intensity physical activity when taking the Fit Tone product. The obtained results of the increase in GUS, FFV and Tiffno test indicate an increase in both functional capabilities and functional abilities of the external breathing system, as well as an increase in the efficiency of the respiratory center in athletes who received the tested product. The effectiveness of the test product is confirmed by the results of dynamic and stress samples in a stabilometric study. Results of examination of psychophysical status of single wrestlers showed that during usage of developed product such indicators as performance, vegetative coefficient, dynamism, speed of movement, accuracy of actions, stability of actions are significantly increased. At the same time, the level of fatigue and anxiety is reliably reduced.Conclusions: the results of the researches performed showed that the product developed demonstrated efficacy for most of the parameters under research in the main group compared to the control (placebo)

Characterization of the complete genome sequence of the recombinant norovirus GII.P16/GII.4_Sydney_2012 revealed in Russia

Noroviruses (the Caliciviridae family) are a common cause of acute gastroenteritis in all age groups. These small non-envelope viruses with a single-stranded (+)RNA genome are characterized by high genetic variability. Continuous changes in the genetic diversity of co-circulating noroviruses and the emergence of new recombinant variants are observed worldwide. Recently, new recombinant noroviruses with a novel GII.P16 polymerase associated with different capsid proteins VP1 were reported. As a part of the surveillance study of sporadic cases of acute gastroenteritis in Novosibirsk, a total of 46 clinical samples from children with diarrhea were screened in 2016. Norovirus was detected in six samples from hospitalized children by RT-PCR. The identified noroviruses were classified as recombinant variants GII.P21/GII.3, GII.Pe/GII.4_Sydney_2012, and GII.P16/GII.4_Sydney_2012 by sequencing of the ORF1/ORF2 junction. In Novosibirsk, the first appearance of the new recombinant genotype GII.P16/GII.4_Sydney_2012 was recorded in spring 2016. Before this study, only four complete genome sequences of the Russian GII.P16/GII.3 norovirus strains were available in the GenBank database. In this work, the complete genome sequence of the Russian strain Hu/GII.P16-GII.4/RUS/Novosibirsk/NS16-C38/2016 (GenBank KY210980) was determined. A comparison of the nucleotide and the deduced amino acid sequences showed a high homology of the Russian strain with GII.P16/GII.4_Sydney_2012 strains from other parts of the world. A comparative analysis showed that several unique substitutions occurred in the GII.P16 polymerase, N-terminal p48 protein, and minor capsid protein VP2 genes, while no unique changes in the capsid VP1 gene were observed. A functional significance of these changes suggests that a wide distribution of the strains with the novel GII.P16 polymerase may be associated both with several amino acid substitutions in the polymerase active center and with the insertion of glutamic acid or glycine in an N-terminal p48 protein that blocks the secretory immunity of intestinal epithelial cells. Further monitoring of genotypes will allow determining the distribution of norovirus recombinants with the polymerase GII.P16 in Russia