Assessment of the DNA damage level in peripheral blood leukocytes of mice treated orally with Rapitalam in acute and therapeutic doses

Centre there was performed experimental research, which carried out the identification and quantitative assessment of alkali-labile sites and DNA strand breaks in leukocytes of peripheral blood of male mice treated with Rapitalam. The method is based on the assessment of the integrity of DNA in leukocytes of the whole blood of animals. Rapitalam was administered to animals orally according to 2 schemes: a single acute dose (413 mg/kg, which corresponds to 1/5 LD50 dose) and once daily in a therapeutic dose (3 mg/kg) for 4 day

Pharmacological efficiency of statins and L-norvalin at an endotoxin-induced endothelial dysfunction

In the animals with endotoxin-induced endothelial dysfunction there were imbalance of contractile response of vessels wall observes when carrying out functional tests, increase of coefficient of endothelial dysfunction, decrease in contractility of a myocardium, activation processes of peroxidation of lipids and decreased activity of antioxidant systems, level of stable metabolites of nitrogen oxid

Pharmacological efficacy of an inhibitor of arginase-2 KUD975 with L-NAME-induced endothelial dysfunction

The study of endotelio- and cardioprotective activity of finished dosage forms - tablets, film-coated, containing 10 mg of phenolic nature KUD-975, was shown a statistically significant decrease in blood pressure and the coefficient of endothelial dysfunction on the background of simulation L-NAME-induced pathology. In the group of animals treated with KUD975 found a statistically significant increase in the concentrations of stable metabolites of nitric oxide, which in addition to the normalization of vasodilation says about endothelioprotektive action of the compounds studie

Metabolic cardioprotection: new concepts in implementation of cardioprotective effects of meldonium

Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects. Key issue is the possibility of drug effects on the mitochondria of cardiomyocytes that controls the aerobic metabolism and maintenance of ATP admission into cardiomyocyte

Correction of Experimental Retinal Ischemia by L-Isomer of Ethylmethylhydroxypyridine Malate

An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative-L-isomer of ethylmethylhydroxypyridine malat

Principles of pharmacological correction of pulmonary arterial hypertension

Prostanoids are a promising group of drugs for the treatment of pulmonary arterial hypertension (PAH), since they possess not only vasodilating, but also antiplatelet and antiproliferative actions. Therefore, it seems logical to use prostacyclin and its analogs to treat patients with various forms of PA

Endothelio- and cardioprotective effects of vitamin B₆ and folic acid in modelling methionine-induced hyperhomocysteinemia

The endotelio- and cardioprotective effects of vitamin B₆ (2 mg/kg) and folic acid (0.2mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studie

Pharmacokinetics of a new imidazoline receptor agonist in rat plasma after intragastric and intravenous administration

This study aimed to obtain the pharmacokinetic profiles in rats. Additionally, an HPLC MS/MS method was developed and validated to quantify C7070 in rat plasma. The pharmacokinetic profiles of intragastric and intravenous administration routes at singles doses of 50 mg/kg, were studied in rat

Molecular screening of prospective candidates for TRPA₁ ion channel selective antagonists

Using the molecular modeling techniques, we analyzed spectra of biological activity of a series of promising candidates for selective antagonists of TRPA₁ ion channel in order to find potentially active compounds against pain and inflammatio

Theoretical justification of a purposeful search of potential neurotropic drugs

To optimize targeted search for new nootropic compound