Aardappel maakt zuur voor polymeren

"We hebben nu een patent én een aardappel die het kunstje doet dat het patent beschrijft", vat projectleider Andries Koops van Plant Research International de stand van zaken samen. "Die aardappel hebben we sinds kort, het patent nu een jaar. Daarmee hebben we een modelplant die doet wat het patent beschrijft: hij maakt itaconzuur

Landbouwgrondstoffen

Inventarisatie van initiatieven die te maken hebben met het gebruik van biomassa als grondstof voor energie- of chemietoepassingen: energietransitie in Nederland, mestvergisting en mest/biomassa co-vergisting, vloeibare brandstoffen, ethanol en biodiesel, biomassa voor chemische grondstoffen, wieren

Experimental Test of the Inter-Layer Pairing Models for High-Tc Superconductivity Using Grazing Incidence Infrared Reflectometry

From measurements of the far-infrared reflectivity at grazing angles of incidence with p-polarized light we determined the c-axis Josephson plasma frequencies of the single layer high T_c cuprates Tl_2Ba_2CuO_6 and La_{2-x}Sr_xCuO_4. We detected a strong plasma resonance at 50 cm^{-1} for La_{2-x}Sr_xCuO_4 in excellent agreement with previously published results. For Tl_2Ba_2CuO_6 we were able to determine an upper limit of the unscreened c-axis Josephson plasma frequency 100 cm^{-1} or a c-axis penetration depth > 15 \mu m. The small value of $\omega_J$ stands in contrast to recent a prediction based on the inter-layer tunneling mechanism of superconductivity.Comment: 4 pages, Phys. Rev. B, in press, Revtex, 4 postscript figure

Nieuwe landbouw: inventarisatie van kansen

In opdracht van het Ministerie van LNV inventariseerde en evalueerde PRI de nieuwe productiekansen voor de Nederlandse plantaardige sectoren.Tevens doet PRI aanbevelingen voor beleid en onderzoek. Nieuwe landbouw is één van de projecten van het Transitieteam van het Ministerie. Behandelde thema's in dit rapport: landbouwgrondstoffen, zoutwater landbouw, kasteelt, sociale dienstverlening, ecologische dienstverlening, het nieuwe consumeren en Nederland regielan

Interventies in het aanbod van voedsel : aangrijpingspunten voor overheidsbeleid om het aanbod van gezonde voedselproducten structureel te verbeteren

In opdracht van de ministeries van LNV en VWS geeft dit rapport een aantal aanbod- en productgeoriënteerde interventies die door overheden toegepast kunnen worden om Nederlandse consumenten te verleiden tot gezonder eet- en leefgedrag. Achterliggend doel is om met kwalitatief beter voedsel en een beter consumptiepatroon een bijdrage te leveren aan de algemene gezondheidstoestan

The genetic architecture of the human cerebral cortex

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function

Subcortical volumes across the lifespan: data from 18,605 healthy individuals aged 3-90 years

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns.Education and Child Studie

Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study

Background: The absence of a uniform and clinically relevant definition of severe postpartum haemorrhage hampers comparative studies and optimization of clinical management. The concept of persistent postpartum haemorrhage, based on refractoriness to initial first-line treatment, was proposed as an alternative to common definitions that are either based on estimations of blood loss or transfused units of packed red blood cells (RBC). We compared characteristics and outcomes of women with severe postpartum haemorrhage captured by these three types of definitions. Methods: In this large retrospective cohort study in 61 hospitals in the Netherlands we included 1391 consecutive women with postpartum haemorrhage who received either ≥4 units of RBC or a multicomponent transfusion. Clinical characteristics and outcomes of women with severe postpartum haemorrhage defined as persistent postpartum haemorrhage were compared to definitions based on estimated blood loss or transfused units of RBC within 24 h following birth. Adverse maternal outcome was a composite of maternal mortality, hysterectomy, arterial embolisation and intensive care unit admission. Results: One thousand two hundred sixty out of 1391 women (90.6%) with postpartum haemorrhage fulfilled the definition of persistent postpartum haemorrhage. The majority, 820/1260 (65.1%), fulfilled this definition within 1 h following birth, compared to 819/1391 (58.7%) applying the definition of ≥1 L blood loss and 37/845 (4.4%) applying the definition of ≥4 units of RBC. The definition persistent postpartum haemorrhage captured 430/471 adverse maternal outcomes (91.3%), compared to 471/471 (100%) for ≥1 L blood loss and 383/471 (81.3%) for ≥4 units of RBC. Persistent postpartum haemorrhage did not capture all adverse outcomes because of missing data on timing of initial, first-line treatment. Conclusion: The definition persistent postpartum haemo