393 research outputs found
Meat and bone meal as fertilizer for oats - From slaughter house waste to fertilizer
EU permitted in 2006 the use of meat bone meal(MBM) as fertilizer. MTT Agrifood Research Finland's Kannus conducted a field experiment from 2000 to 2003 with a supplement experiment in 2004. The fertilization effect was 24 % higher after MBM than after chemical fertilizers
Small But Slow World: How Network Topology and Burstiness Slow Down Spreading
Communication networks show the small-world property of short paths, but the
spreading dynamics in them turns out slow. We follow the time evolution of
information propagation through communication networks by using the SI model
with empirical data on contact sequences. We introduce null models where the
sequences are randomly shuffled in different ways, enabling us to distinguish
between the contributions of different impeding effects. The slowing down of
spreading is found to be caused mostly by weight-topology correlations and the
bursty activity patterns of individuals
Don't Miss the Moment:A Systematic Review of Ecological Momentary Assessment in Suicide Research
Suicide and suicide-related behaviors are prevalent yet notoriously difficult to predict. Specifically, short-term predictors and correlates of suicide risk remain largely unknown. Ecological momentary assessment (EMA) may be used to assess how suicidal thoughts and behaviors (STBs) unfold in real-world contexts. We conducted a systematic literature review of EMA studies in suicide research to assess (1) how EMA has been utilized in the study of STBs (i.e., methodology, findings), and (2) the feasibility, validity and safety of EMA in the study of STBs. We identified 45 articles, detailing 23 studies. Studies mainly focused on examining how known longitudinal predictors of suicidal ideation perform within shorter (hourly, daily) time frames. Recent studies have explored the prospects of digital phenotyping of individuals with suicidal ideation. The results indicate that suicidal ideation fluctuates substantially over time (hours, days), and that individuals with higher mean ideation also have more fluctuations. Higher suicidal ideation instability may represent a phenotypic indicator for increased suicide risk. Few studies succeeded in establishing prospective predictors of suicidal ideation beyond prior ideation itself. Some studies show negative affect, hopelessness and burdensomeness to predict increased ideation within-day, and sleep characteristics to impact next-day ideation. The feasibility of EMA is encouraging: agreement to participate in EMA research was moderate to high (median = 77%), and compliance rates similar to those in other clinical samples (median response rate = 70%). More individuals reported suicidal ideation through EMA than traditional (retrospective) self-report measures. Regarding safety, no evidence was found of systematic reactivity of mood or suicidal ideation to repeated assessments of STBs. In conclusion, suicidal ideation can fluctuate substantially over short periods of time, and EMA is a suitable method for capturing these fluctuations. Some specific predictors of subsequent ideation have been identified, but these findings warrant further replication. While repeated EMA assessments do not appear to result in systematic reactivity in STBs, participant burden and safety remains a consideration when studying high-risk populations. Considerations for designing and reporting on EMA studies in suicide research are discussed
Prevalence of obesity and disturbances in glucose homeostasis in HIV-infected subjects and general population - missed diagnoses of diabetes?
Objectives Comparative data on glucose disorders using fasting blood samples between people living with HIV (PLWH) and the general population are lacking. The objective of this study was to compare the prevalence and risk factors of obesity and disturbances in glucose homeostasis between PLWH treated with modern antiretroviral therapy and the general population. Methods Adjusted prevalence of obesity, features of insulin resistance (triglyceride:high-density lipoprotein cholesterol ratio and alanine aminotransferase), impaired fasting glucose (IFG), diabetes mellitus (DM) and combined dysglycaemia (presence of IFG or DM) were determined using fasting blood samples among 1041 PLWH and 7047 subjects representing the general population. Results People living with HIV had a lower prevalence of obesity [18.2%, 95% confidence interval (CI): 15.1-21.2 vs. 23.9%, 95% CI: 22.4-25.4], but a higher prevalence of insulin resistance and IFG (20.0%, 95% CI: 16.6-23.4 vs. 9.8%, 95% CI: 8.7-10.8) than the general population. Fasting glucose concentration was higher, but glycated haemoglobin (HbA1c) was lower, among PLWH. Prevalence of dysglycaemia for a given body mass index (BMI) was higher in PLWH than in the general population. The prevalence of DM did not differ between PLWH (13.2%, 95% CI: 10.2-15.9) and the general population (14.5%, 95% CI: 13.6-15.4). Conclusions The prevalence of obesity was lower, but the risk of dysglycaemia for a given BMI was significantly higher, among PLWH, highlighting the importance of prevention and treatment of obesity among HIV-infected subjects. Regardless of the increased prevalence of insulin resistance and IFG, DM was surprisingly not more common among PLWH, raising concern about the under-diagnosis of DM, possibly due to low sensitivity of HbA1c in this patient population.Peer reviewe
The Unreasonable Effectiveness of Contact Tracing on Networks with Cliques
Contact tracing, the practice of isolating individuals who have been in
contact with infected individuals, is an effective and practical way of
containing disease spread. Here, we show that this strategy is particularly
effective in the presence of social groups: Once the disease enters a group,
contact tracing not only cuts direct infection paths but can also pre-emptively
quarantine group members such that it will cut indirect spreading routes. We
show these results by using a deliberately stylized model that allows us to
isolate the effect of contact tracing within the clique structure of the
network where the contagion is spreading. This will enable us to derive
mean-field approximations and epidemic thresholds to demonstrate the efficiency
of contact tracing in social networks with small groups. This analysis shows
that contact tracing in networks with groups is more efficient the larger the
groups are. We show how these results can be understood by approximating the
combination of disease spreading and contact tracing with a complex contagion
process where every failed infection attempt will lead to a lower infection
probability in the next attempts. Our results illustrate how contract tracing
in real-world settings can be more efficient than predicted by models that
treat the system as fully mixed or the network structure as locally tree-like.Comment: 15 pages, 13 figures, 4 table
The International Trade Network: weighted network analysis and modelling
Tools of the theory of critical phenomena, namely the scaling analysis and
universality, are argued to be applicable to large complex web-like network
structures. Using a detailed analysis of the real data of the International
Trade Network we argue that the scaled link weight distribution has an
approximate log-normal distribution which remains robust over a period of 53
years. Another universal feature is observed in the power-law growth of the
trade strength with gross domestic product, the exponent being similar for all
countries. Using the 'rich-club' coefficient measure of the weighted networks
it has been shown that the size of the rich-club controlling half of the
world's trade is actually shrinking. While the gravity law is known to describe
well the social interactions in the static networks of population migration,
international trade, etc, here for the first time we studied a non-conservative
dynamical model based on the gravity law which excellently reproduced many
empirical features of the ITN.Comment: 5 pages, 5 figure
Weighted growing simplicial complexes
(14 pages, 6 figures)(14 pages, 6 figures
From Relational Data to Graphs: Inferring Significant Links using Generalized Hypergeometric Ensembles
The inference of network topologies from relational data is an important
problem in data analysis. Exemplary applications include the reconstruction of
social ties from data on human interactions, the inference of gene
co-expression networks from DNA microarray data, or the learning of semantic
relationships based on co-occurrences of words in documents. Solving these
problems requires techniques to infer significant links in noisy relational
data. In this short paper, we propose a new statistical modeling framework to
address this challenge. It builds on generalized hypergeometric ensembles, a
class of generative stochastic models that give rise to analytically tractable
probability spaces of directed, multi-edge graphs. We show how this framework
can be used to assess the significance of links in noisy relational data. We
illustrate our method in two data sets capturing spatio-temporal proximity
relations between actors in a social system. The results show that our
analytical framework provides a new approach to infer significant links from
relational data, with interesting perspectives for the mining of data on social
systems.Comment: 10 pages, 8 figures, accepted at SocInfo201
Clinical Spectrum and Geographic Distribution of Keratitis Fugax Hereditaria Caused by the Pathogenic Variant c.61G>C in NLRP3
Publisher Copyright: © 2021 The Author(s)PURPOSE: To chart clinical findings in individuals with keratitis fugax hereditaria (KFH) and the geographic distribution of their ancestors. DESIGN: A prospective cross-sectional study. METHODS: This study took place in a tertiary referral center with a cohort of 84 Finnish patients (55% female) from 25 families with the pathogenic nucleotide-binding domain, leucine-rich repeat (NLR) family pyrin domain containing 3 (NLRP3) variant c.61G>C. Observation procedures and main outcome measures were Sanger sequencing, clinical examination, corneal imaging, and a questionnaire regarding symptoms, quality of life, treatment, and comorbidities. RESULTS: The oldest members in each family were born in Ostrobothnia in Western Finland or in Southwestern Finland with historical ties to Sweden. One carrier was asymptomatic. Most (77%, 46/60) experienced their first attack between age 6 and 20 years. Three-quarters had unilateral attacks 3 to 5 times annually, primarily triggered by cold wind or air, or stress. Eighty percent (48/60) reported ocular pain (median, 7 on scale 1-10), conjunctival injection, photophobia, foreign body sensation, and tearing during attacks. Visual blur occurred in 75% (45/60) and 91% (55/60) during and after the attack, respectively, for a median of 10 days (range, 1 day-2 months). Forty-seven percent (39/60) had corneal oval opacities with irregular tomography patterns and mild to moderate decrease (20/60 or better) in best-corrected visual acuity that improved with scleral contact lenses. Except for headache in 40%, systemic symptoms were absent during the attacks. CONCLUSIONS: Symptoms and signs of KFH are restricted to the anterior segment of the eye and vary widely between individuals. We recommend scleral contact lenses as the first-line treatment for reduced vision. Allele frequencies suggest that KFH goes unrecognized in Sweden and populations with Scandinavian heritage.Peer reviewe
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