59 research outputs found
Biotransformation of Underutilized Natural Resource to Valuable Compounds in Ionic Liquid: Enzymatic Synthesis of Caffeic Acid Phenethyl Ester Analogues from Immature Coffee Beans
1047-180 Low high-density lipoprotein cholesterol, hypertension, diabetes, but not high low-density lipoprotein cholesterol as predictors of acute coronary syndrome in northern area of Japan: A case-control study
Improvement of a Plate Culture Method for Thiobacillus thiooxidans and Isolation of a New Strain
Thiobacillus thiooxidansは固体平板培地上でのコロニー形成が悪く,遺伝子操作を行うために欠かせない技術であるクローンの選抜が困難であったため,遺伝学的研究は従属細菌のそれに比して著しく遅れていた.本論文では,T.thiooxidansの個体平板培養法の改良を目的として,エネルギー源,ゲル化剤について検討し,得られた新しい固体培養法を用いて固体平板培地上で生育の速い菌株を分離した.新しい培地はSilvermanとLundgrenの9K培地の無機塩にエネルギー源として0.3% の四チオン酸,ゲル化剤として0.6% のジェランガムを用いた.分離株には,従属栄養生育能は認められなかったが,元素硫黄および四チオン酸を含む9K培地での良好な生育は確認できた.さらに,キノンがユビキノン8であり,菌体脂肪酸には3-ヒドロキシミリスチン酸が含まれること,GC含量が52% であること等の菌学的諸性質から分離株はT.thiooxidansに属する菌株であることが確認できた.この菌株と新しい平板培地を用いると,従属栄養細菌に匹敵する大型コロニーが得られ,細胞選抜を容易に行うことが出来る
Magnetized Fast Isochoric Laser Heating for Efficient Creation of Ultra-High-Energy-Density States
The quest for the inertial confinement fusion (ICF) ignition is a grand
challenge, as exemplified by extraordinary large laser facilities. Fast
isochoric heating of a pre-compressed plasma core with a high-intensity
short-pulse laser is an attractive and alternative approach to create
ultra-high-energy-density states like those found in ICF ignition sparks. This
avoids the ignition quench caused by the hot spark mixing with the surrounding
cold fuel, which is the crucial problem of the currently pursued ignition
scheme. High-intensity lasers efficiently produce relativistic electron beams
(REB). A part of the REB kinetic energy is deposited in the core, and then the
heated region becomes the hot spark to trigger the ignition. However, only a
small portion of the REB collides with the core because of its large
divergence. Here we have demonstrated enhanced laser-to-core energy coupling
with the magnetized fast isochoric heating. The method employs a
kilo-tesla-level magnetic field that is applied to the transport region from
the REB generation point to the core which results in guiding the REB along the
magnetic field lines to the core. 7.7 1.3 % of the maximum coupling was
achieved even with a relatively small radial area density core (
0.1 g/cm). The guided REB transport was clearly visualized in a
pre-compressed core by using Cu- imaging technique. A simplified
model coupled with the comprehensive diagnostics yields 6.2\% of the coupling
that agrees fairly with the measured coupling. This model also reveals that an
ignition-scale areal density core ( 0.4 g/cm) leads to much
higher laser-to-core coupling ( 15%), this is much higher than that achieved
by the current scheme
Triple-Tube-Ostomy: A Novel Technique for the Surgical Treatment of Iatrogenic Duodenal Perforation
Although duodenal perforation is currently an infrequent complication of medical procedures, its incidence in the future predictably will increase as endoscopic treatment of duodenal neoplasms becomes more frequently used. In some cases, duodenal perforation is difficult to treat even surgically. We report here a novel technique called ‘triple-tube-ostomy’ for the treatment of iatrogenic duodenal perforation. Since November 2009, there have been three cases of iatrogenic perforation of the duodenum, due to various causes, which we have treated with our novel technique. The main principles of the technique are biliary diversion, decompression of the duodenum, and early enteral nutrition. All patients who underwent the triple-tube-ostomy procedure had good postoperative courses, with few complications. The novel surgical technique we describe in this report is safe, reliable, easy to learn and perform, and led to a good postoperative course in all cases where we performed it
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
Randomized phase II study of pemetrexed or pemetrexed plus bevacizumab for elderly patients with previously untreated non-squamous non-small cell lung cancer: Results of the Lung Oncology Group in Kyushu (LOGIK1201)
Objectives: To evaluate the efficacy and safety, we conducted a randomized phase II study of pemetrexed (Pem) versus Pem + bevacizumab (Bev) for elderly patients with non-squamous non-small cell lung cancer (NSqNSCLC). Patients and methods: The eligibility criteria were as follows: NSqNSCLC, no prior therapy,stage IIIB/IV disease or postoperative recurrence, age: ?75 years, performance status (PS): 0?1, and adequate bone marrow function. The patients were randomly assigned (1:1 ratio)to receive Pem or Pem + Bev. The primary endpoint was progression-free survival (PFS).The secondary endpoints were the response rate, OS, toxicities, and cost-effectiveness. Results: Forty-one patients were enrolled and 40 (20 from each group) were assessable. Their characteristics were as follows: male/female = 23/17; median age (range) = 78 (75?83); stage IIIB/IV/postoperative recurrence = 1/30/9; PS 0/1 = 11/29. All cases involved adenocarcinoma.There was no significant intergroup difference in PFS and the median PFS (95% confidence interval) values of the Pem and Pem + Bev groups were 5.4 (3.0?7.4) and 5.5 (3.6?9.9) months, respectively (p = 0.66). The response rate was significantly higher in the Pem + Bev group(15% vs. 55%, p = 0.0146), and there was no significant difference in OS (median: 16.0 vs. 16.4 months, p = 0.58). Grade 3 and 4 leukopenia, neutropenia,and thrombocytopenia were seen in 10 and 30, 20 and 55, and 5 and 5 cases, respectively. Drug costs were higher in the Pem + Bev group (median: 1,522,008 vs. 3,368,428 JPY, p = 0.01). No treatment-related deaths occurred. Conclusions: Adding Bev to Pem did not result in improved survival in the elderly NSqNSCLC patients. Compared with Pem + Bev, Pem monotherapy had similar effects on survival, a more favorable toxicity profile, and was more cost-effective in elderly NSqNSCLC patients. Pem monotherapy might be one of the optional regimen for NSqNSCLC patients aged ?75 years
Revascularization of Malignant Coronary Instent Restenosis Resulting From Takayasu's Arteritis Using Sirolimus-Eluting Stents
A 37 year-old female who had suffered from arteritis for 20 years underwent a Bentall operation. Since severe stenosis was observed in her left main coronary artery (LMCA) the following year, a minimally invasive direct coronary artery bypass (MIDCAB) operation was performed. Unfortunately, she again complained of angina about 6 months after the second surgery and coronary angiography (CAG) revealed that her left internal thoracic artery graft was totally occluded. Although a 4.0 × 15 mm S670 stent was placed in her LMCA, the LMCA restenosed every 3 months and she underwent reintervention 8 times. We placed 2 sirolimus-eluting stents for treating the LMCA using the culottes stenting technique. CAG 6 months after the index procedure showed no stenosis at her LMCA. Sirolimus-eluting stents were effective for treating stenosis resulting from arteritis as well as that caused by atherosclerosis
Skin infiltration of nodal peripheral T-cell lymphoma-not otherwise specified identified by skin biopsy of faint eruptions
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