Hyperglycemia and Hyperlipidemia Act Synergistically to Induce Renal Disease in LDL Receptor-Deficient BALB Mice

Diabetic nephropathy is the leading cause of end-stage renal disease in Western countries, but only a portion of diabetic patients develop diabetic nephropathy. Dyslipidemia represents an important aspect of the metabolic imbalance in diabetic patients. In this study, we addressed the impact of combined hyperlipidemia and hyperglycemia on renal pathology. Kidneys from wildtype (WT) or LDL receptor-deficient BALB/cBy mice (BALB. LDLR -/-) were examined at 22 weeks of age. Diabetes was induced by administration of streptozotocin and mice were randomly assigned to either standard chow or Western diet. Chow fed BALB. LDLR -/- mice did not demonstrate renal abnormalities, whereas BALB. LDLR -/- mice fed a Western diet showed occasional glomerular and tubulointerstitial foam cells. Diabetic WT mice had modestly increased glomerular cellularity and extracellular matrix. Hyperlipidemic and diabetic BALB. LDLR -/- mice exhibited an increase in glomerular cellularity and extracellular matrix, accumulation of glomerular and tubulointerstitial foam cells and mesangial lipid deposits. The tubular epithelium demonstrated pronounced lipid induced tubular degeneration with increased tubular epithelial cell turnover. Hyperlipidemia and hyperglycemia seem to act synergistically in inducing renal injury in the BALB. LDLR-/- mouse. This model of diabetic nephropathy is unique in its development of tubular lesions and may represent a good model for hyperlipidemia-exacerbated diabetic nephropathy. Copyright (C) 2004 S. Karger AG, Basel

Using Light to Treat Mucositis and Help Wounds Heal

A continuing program of research and development is focusing on the use of controlled illumination by light-emitting diodes (LEDs) to treat mucositis and to accelerate healing of wounds. The basic idea is to illuminate the affected area of a patient with light of an intensity, duration, and wavelength (or combination of wavelengths) chosen to produce a therapeutic effect while generating only a minimal amount of heat. This method of treatment was originally intended for treating the mucositis that is a common complication of chemotherapy and radiation therapy for cancer. It is now also under consideration as a means to accelerate the healing of wounds and possibly also to treat exposure to chemical and radioactive warfare agents. Radiation therapy and many chemotherapeutic drugs often damage the mucosal linings of the mouth and gastrointestinal tract, leading to mouth ulcers (oral mucositis), nausea, and diarrhea. Hyperbaric-oxygen therapy is currently the standard of care for ischemic, hypoxic, infected, and otherwise slowlyhealing problem wounds, including those of oral mucositis. Hyperbaric-oxygen therapy increases such cellular activities as collagen production and angiogenesis, leading to an increased rate of healing. Biostimulation by use of laser light has also been found to be effective in treating mucositis. For hyperbaricoxygen treatment, a patient must remain inside a hyperbaric chamber for an extended time. Laser treatment is limited by laser-wavelength capabilities and by narrowness of laser beams, and usually entails the generation of significant amounts of heat

On the size of the Fe II emitting region in the AGN Akn 120

We present a reverberation analysis of the strong, variable optical Fe II emission bands in the spectrum of Akn 120, a low-redshift AGN which is one of the best candidates for such a study. On time scales of several years the Fe II line strengths follow the variations in the continuum strength. However, we are unable to measure a clear reverberation lag time for these Fe II lines on any time scale. This is due to the very broad and flat-topped nature of the Fe II cross correlation functions, as compared to the H-beta response which is much more sharply localized in time. Although there is some suggestion in the light curve of a 300-day response time, our statistical analysis does not pick up such a feature. We conclude that the optical Fe II emission does not come from a photoionization-powered region similar in size to the H-beta emitting region, but we cannot say for sure where it does come from. Our results are generally consistent either with emission from a photoionized region several times larger than the H-beta zone, or with emission from gas heated by some other means, perhaps responding only indirectly to the continuum variations.Comment: Accepted for publication in the Ap

BLIMPK/Streamline Surface Catalytic Heating Predictions on the Space Shuttle Orbiter

This paper describes the results of an analysis of localized catalytic heating effects to the U.S. Space Shuttle Orbiter Thermal Protection System (TPS). The analysis applies to the High-temperature Reusable Surface Insulation (HRSI) on the lower fuselage and wing acreage, as well as the critical Reinforced Carbon-Carbon on the nose cap, chin panel and the wing leading edge. The object of the analysis was to use a modified two-layer approach to predict the catalytic heating effects on the Orbiter windward HRSI tile acreage, nose cap, and wing leading edge assuming localized highly catalytic or fully catalytic surfaces. The method incorporated the Boundary Layer Integral Matrix Procedure Kinetic (BLIMPK) code with streamline inputs from viscous Navier-Stokes solutions to produce heating rates for localized fully catalytic and highly catalytic surfaces as well as for nominal partially catalytic surfaces (either Reinforced Carbon-Carbon or Reaction Cured Glass) with temperature-dependent recombination coefficients. The highly catalytic heating results showed very good correlation with Orbiter Experiments STS-2, -3, and -5 centerline and STS-5 wing flight data for the HRSI tiles. Recommended catalytic heating factors were generated for use in future Shuttle missions in the event of quick-time analysis of damaged or repaired TPS areas during atmospheric reentry. The catalytic factors are presented along the streamlines as well as a function of stagnation enthalpy so they can be used for arbitrary trajectories

Diffuse Galactic Gamma Rays from Shock-Accelerated Cosmic Rays

A shock-accelerated particle flux \propto p^-s, where p is the particle momentum, follows from simple theoretical considerations of cosmic-ray acceleration at nonrelativistic shocks followed by rigidity-dependent escape into the Galactic halo. A flux of shock-accelerated cosmic-ray protons with s ~ 2.8 provides an adequate fit to the Fermi-LAT gamma-ray emission spectra of high-latitude and molecular cloud gas when uncertainties in nuclear production models are considered. A break in the spectrum of cosmic-ray protons claimed by Neronov, Semikoz, & Taylor (PRL, 108, 051105, 2012) when fitting the gamma-ray spectra of high-latitude molecular clouds is a consequence of using a cosmic-ray proton flux described by a power law in kinetic energy.Comment: Version to correspond to published letter in PRL; corrected Fig.

Thermal Testing of a Stacked Core Mirror for UV Applications

The ASTRO2010 Decadal Survey stated that an advanced large-aperture ultraviolet, optical, near-infrared (UVOIR) telescope is required to enable the next generation of compelling astrophysics and exoplanet science; and, that present technology is not mature enough to affordably build and launch any potential UVOIR mission concept. Under Science and Technology funding, NASA's Marshall Space Flight Center and ITT Exelis have developed a more cost effective process to make 4m monolithic spaceflight UV quality, low areal density, thermally and dynamically stable primary mirrors. A proof of concept mirror was built and tested down to 250K which would allow imaging out to 2.5 microns. This mirror was thermally tested at the Marshall Spaceflight Center to understand the thermal changes between the processing temperature of 293K and the potential low end of the operational temperature of 250K. Isothermal testing results and front plate gradient results have been evaluated and compared to analysis predictions. Measurement of gravity effects on surface figure will be compared to analytical predictions. Future testing of a larger Pathfinder mirror will also be discussed

A Meta-Analysis of the Incidence of Non-AIDS Cancers in HIV-Infected Individuals

To estimate summary standardized incidence ratios (SIRs) of non-AIDS cancers among HIV-infected individuals compared to general population rates overall and stratified by gender, AIDS and highly active antiretroviral therapy (HAART) era

Thermal Testing of a Stacked Core Mirror for UV Applications

The ASTRO2010 Decadal Survey stated that an advanced large-aperture ultraviolet, optical, near-infrared (UVOIR) telescope is required to enable the next generation of compelling astrophysics and exoplanet science; and, that present technology is not mature enough to affordably build and launch any potential UVOIR mission concept. Under Science and Technology funding, NASA's Marshall Space Flight Center and ITT Exelis have developed a more cost effective process to make 4m monolithic spaceflight UV quality, low areal density, thermally and dynamically stable primary mirrors. A proof of concept mirror was built and tested down to 250K which would allow imaging out to 2.5 microns. This mirror was thermally tested at the Marshall Spaceflight Center to understand the thermal changes between the processing temperature of 293K and the potential low end of the operational temperature of 250K. Isothermal testing results and front plate gradient results have been evaluated and compared to analysis predictions. Measurement of gravity effects on surface figure will be compared to analytical predictions. Future testing of a larger Pathfinder mirror will also be discussed

Stellar Kinematics of Young Clusters in Turbulent Hydrodynamic Simulations

The kinematics of newly-formed star clusters are interesting both as a probe of the state of the gas clouds from which the stars form, and because they influence planet formation, stellar mass segregation, cluster disruption, and other processes controlled in part by dynamical interactions in young clusters. However, to date there have been no attempts to use simulations of star cluster formation to investigate how the kinematics of young stars change in response to variations in the properties of their parent molecular clouds. In this letter we report the results of turbulent self-gravitating simulations of cluster formation in which we consider both clouds in virial balance and those undergoing global collapse. We find that stars in these simulations generally have velocity dispersions smaller than that of the gas by a factor of ~ 5, independent of the dynamical state of the parent cloud, so that subvirial stellar velocity dispersions arise naturally even in virialized molecular clouds. The simulated clusters also show large-scale stellar velocity gradients of ~0.2-2 km s$^{-1}$ pc$^{-1}$ and strong correlations between the centroid velocities of stars and gas, both of which are observed in young clusters. We conclude that star clusters should display subvirial velocity dispersions, large-scale velocity gradients, and strong gas-star velocity correlations regardless of whether their parent clouds are in virial balance, and, conversely, that observations of these features cannot be used to infer the dynamical state of the parent gas clouds.Comment: 5 pages, 4 figures, accepted to ApJ

An improved method of in vivo wound disruption and measurement

Biomechanical studies of wound strength are important because of new investigations in growth factors, cytokines, and fetal wounds. We compared two traditional methods of wound disruption measurement with a novel computerized model designed for in vivo experiments. An Instron tensiometer (INSTS) and an air insufflated positive pressure device (AIPPD) were compared with a vacuum-controlled wound chamber device (VCWCD). The VCWCD produced vacuum at the wound site and wound disruption was monitored with two video camera/recorders. Rats were marked with a template guide for a 2.5 cm, full-thickness, abdominal incisional wound. Rats were divided into three groups and studied at 2, 7, or 14 days after wounding. The recorded images were computer digitalized to generate wound strength curves from a three-dimensional model. A comparison of the wound disruption curves demonstrated that the VCWCD was comparable to the INST or AIPPD in normal wound healing (P> .40). The VCWCD provided data with less standard error at 2 days after wounding (P P in vivo method which required minimal wound manipulation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30176/1/0000561.pd