Testing, analysis, and code verification of aerodynamics and heat transfer related to turbomachinery

Discussed here are the writing of a data acquisition code and the installation and testing of new pressure and temperature instrumentation to be used in the testing and evaluation of miniature heat flux sensors. A brief summary of the problem which led to the need for these tests is presented as well as a proposed data acquisition program and the results of investigations of two measurement systems, the Omega OM-900 temperature sensing system and the Scani-Valve Hyscan pressure measurement system

External Shear in Quadruply Imaged Lens Systems

We use publicly available N-body simulations and semi-analytic models of galaxy formation to estimate the levels of external shear due to structure near the lens in gravitational lens systems. We also describe two selection effects, specific to four-image systems, that enhance the probability of observing systems to have higher external shear. Ignoring additional contributions from "cosmic shear" and assuming that lens galaxies are not significantly flattened, we find that the mean shear at the position of a quadruple lens galaxy is 0.11, the rms shear is roughly 0.15, and there is roughly a 45% likelihood of external shear greater than 0.1. This is much larger than previous estimates and in good agreement with typical measured external shear. The higher shear primarily stems from the tendency of early-type galaxies, which are the majority of lenses, to reside in overdense regions.Comment: 5 pages, 2 figures, ApJ in press, minor revision

Propagation of Detonation Waves in Tubes Split from a PDE Thrust Tube

A Pulse Detonation Engine (PDE) combusts a fuel air mixture through detonation. Existing designs require spark plugs in each separate thrust tube to ignite premixed reactants. A single thrust tube could require the spark plug to fire hundreds of times per second for long durations. This paper reports on the use of a continuously propagating detonation wave as both a thrust producer and a single ignition source for a multi-tube system. The goal was to minimize ignition complexity and increase reliability by limiting the number of ignition sources. The work includes a systematic investigation of single tube geometric effects on detonations. These results were subsequently used to further examine conditions for splitting detonations i.e. the division of a detonation wave into two separate detonation waves. Finally a dual thrust tube system was built and tested that successfully employed a single spark to initiate detonation in separate thrust tubes

HST Studies of the WLM Galaxy. I. The Age and Metallicity of the Globular Cluster

We have obtained V and I images of the lone globular cluster that belongs to the dwarf Local Group irregular galaxy known as WLM. The color-magnitude diagram of the cluster shows that it is a normal old globular cluster with a well-defined giant branch reaching to M_V=-2.5, a horizontal branch at M_V=+0.5, and a sub-giant branch extending to our photometry limit of M_V=+2.0. A best fit to theoretical isochrones indicates that this cluster has a metallicity of [Fe/H]=-1.52\pm0.08 and an age of 14.8\pm0.6 Gyr, thus indicating that it is similar to normal old halo globulars in our Galaxy. From the fit we also find that the distance modulus of the cluster is 24.73\pm0.07 and the extinction is A_V=0.07\pm0.06, both values that agree within the errors with data obtained for the galaxy itself by others. We conclude that this normal massive cluster was able to form during the formation of WLM, despite the parent galaxy's very small intrinsic mass and size.Comment: 14 pages, 5 figures, 1 tabl

Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes.

PurposeAbnormalities in cerebrospinal fluid (CSF) have been reported in Hurler syndrome, a fatal neurodegenerative lysosomal disorder. While no biomarker has predicted neurocognitive response to treatment, one of these abnormalities, glycosaminoglycan nonreducing ends (NREs), holds promise to monitor therapeutic efficacy. A trial of intrathecal enzyme replacement therapy (ERT) added to standard treatment enabled tracking of CSF abnormalities, including NREs. We evaluated safety, biomarker response, and neurocognitive correlates of change.MethodsIn addition to intravenous ERT and hematopoietic cell transplantation, patients (N = 24) received intrathecal ERT at four peritransplant time points; CSF was evaluated at each point. Neurocognitive functioning was quantified at baseline, 1 year, and 2 years posttransplant. Changes in CSF biomarkers and neurocognitive function were evaluated for an association.ResultsOver treatment, there were significant decreases in CSF opening pressure, biomarkers of disease activity, and markers of inflammation. Percent decrease in NRE from pretreatment to final intrathecal dose posttransplant was positively associated with percent change in neurocognitive score from pretreatment to 2 years posttransplant.ConclusionIntrathecal ERT was safe and, in combination with standard treatment, was associated with reductions in CSF abnormalities. Critically, we report evidence of a link between a biomarker treatment response and neurocognitive outcome in Hurler syndrome

Gamma-ray bursts: Restarting the Engine

Recent gamma-ray burst observations have revealed late-time, highly energetic events which deviate from the simplest expectations of the standard fireball picture. Instead they may indicate that the central engine is active or restarted at late times. We suggest that fragmentation and subsequent accretion during the collapse of a rapidly rotating stellar core offers a natural mechanism for this.Comment: 8 pages, 1 figure; accepted by ApJ Letter

Environmental Chamber for in Situ Dynamic Control of Temperature and Relative Humidity During X-Ray Scattering

We have designed, constructed, and evaluated an environmental chamber that has in situ dynamic control of temperature (25 to 90 °C) and relative humidity (0% to 95%). The compact specimen chamber is designed for x-ray scattering in transmission with an escape angle of 2θ = ±30°. The specimen chamber is compatible with a completely evacuated system such as the Rigaku PSAXS system, in which the specimen chamber is placed inside a larger evacuated chamber (flight path). It is also compatible with x-ray systems consisting of evacuated flight tubes separated by small air gaps for sample placement. When attached to a linear motor (vertical displacement), the environmental chamber can access multiple sample positions. The temperature and relative humidity inside the specimen chamber are controlled by passing a mixture of dry and saturated gas through the chamber and by heating the chamber walls. Alternatively, the chamber can be used to control the gaseous environment without humidity. To illustrate the value of this apparatus, we have probed morphology transformations in Nafion® membranes and a polymerized ionic liquid as a function of relative humidity in nitrogen

Quantum state engineering on an optical transition and decoherence in a Paul trap

A single Ca+ ion in a Paul trap has been cooled to the ground state of vibration with up to 99.9% probability. Starting from this Fock state |n=0> we have demonstrated coherent quantum state manipulation on an optical transition. Up to 30 Rabi oscillations within 1.4 ms have been observed. We find a similar number of Rabi oscillations after preparation of the ion in the |n=1> Fock state. The coherence of optical state manipulation is only limited by laser and ambient magnetic field fluctuations. Motional heating has been measured to be as low as one vibrational quantum in 190 ms.Comment: 4 pages, 5 figure

Whole-genome and long-read sequencing identify a novel mechanism in RFC1 resulting in CANVAS syndrome

OBJECTIVES: Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) results from biallelic intronic pentanucleotide repeats in METHODS: We performed whole-genome sequencing (WGS) on peripheral blood DNA samples from the proband and his unaffected mother. We performed DNA long-read sequencing and synthesized complementary DNA from RNA using peripheral blood from the proband. RESULTS: WGS confirmed the maternally inherited DISCUSSION: We report an adult with CANVAS due to compound heterozygous pathogeni

Historical Criminology and the Explanatory Power of the Past

To what extent can the past ‘explain’ the present? This deceptively simple question lies at the heart of historical criminology (research which incorporates historical primary sources while addressing present-day debates and practices in the criminal justice field). This article seeks first to categorise the ways in which criminologists have used historical data thus far, arguing that it is most commonly deployed to ‘problematize’ the contemporary rather than to ‘explain’ it. The article then interrogates the reticence of criminologists to attribute explicative power in relation to the present to historical data. Finally, it proposes the adoption of long time-frame historical research methods, outlining three advantages which would accrue from this: the identification and analysis of historical continuities; a more nuanced, shared understanding of micro/macro change over time in relation to criminal justice; and a method for identifying and analysing instances of historical recurrence, particularly in perceptions and discourses around crime and justice