Cell phone based balance trainer

<p>Abstract</p> <p>Background</p> <p>In their current laboratory-based form, existing vibrotactile sensory augmentation technologies that provide cues of body motion are impractical for home-based rehabilitation use due to their size, weight, complexity, calibration procedures, cost, and fragility.</p> <p>Methods</p> <p>We have designed and developed a cell phone based vibrotactile feedback system for potential use in balance rehabilitation training in clinical and home environments. It comprises an iPhone with an embedded tri-axial linear accelerometer, custom software to estimate body tilt, a "tactor bud" accessory that plugs into the headphone jack to provide vibrotactile cues of body tilt, and a battery. Five young healthy subjects (24 ± 2.8 yrs, 3 females and 2 males) and four subjects with vestibular deficits (42.25 ± 13.5 yrs, 2 females and 2 males) participated in a proof-of-concept study to evaluate the effectiveness of the system. Healthy subjects used the system with eyes closed during Romberg, semi-tandem Romberg, and tandem Romberg stances. Subjects with vestibular deficits used the system with both eyes-open and eyes-closed conditions during semi-tandem Romberg stance. Vibrotactile feedback was provided when the subject exceeded either an anterior-posterior (A/P) or a medial-lateral (M/L) body tilt threshold. Subjects were instructed to move away from the vibration.</p> <p>Results</p> <p>The system was capable of providing real-time vibrotactile cues that informed corrective postural responses. When feedback was available, both healthy subjects and those with vestibular deficits significantly reduced their A/P or M/L RMS sway (depending on the direction of feedback), had significantly smaller elliptical area fits to their sway trajectory, spent a significantly greater mean percentage time within the no feedback zone, and showed a significantly greater A/P or M/L mean power frequency.</p> <p>Conclusion</p> <p>The results suggest that the real-time feedback provided by this system can be used to reduce body sway. Its advantages over more complex laboratory-based and commercial balance training systems in terms of cost, size, weight, functionality, flexibility, and accessibility make it a good candidate for further home-based balance training evaluation.</p

Revisiting the Seasonal Variations of Sea-Air CO2 Fluxes in the Northern East China Sea

Temperature, salinity, chlorophyll a (Chl-a), nitrate, and sea-air differences of CO2 partial pressure (ΔpCO2) were extensively investigated in the northern East China Sea (ECS) during seven research cruises from 2003 to 2009. The ΔpCO2 showed large intraseasonal variation in the spring and summer. In spring, the areal mean ΔpCO2 in May 2004 was almost half of that in April 2008, probably associated with differences in sea surface temperature (SST). In summer, the areal mean ΔpCO2 in August 2003 was also twice as large as that in July 2006. In addition, ΔpCO2 exhibited large seasonal variation with positive values in autumn and negative values in other seasons. The positive ΔpCO2 in autumn was ascribed to vertical mixing with CO2-enriched subsurface waters and relatively high SST in this season. The annually integrated sea-air CO2 flux in the northern ECS was -2.2 ± 2.1 mol m-2 yr-1, indicating CO2 absorption from atmosphere to the sea, which was more than two times lower than the previous estimate (Shim et al. 2007) reported for the same region. This large difference was presumably responsible for the underestimation of winter CO2 influx by Shim et al. (2007) and the large interannual variation of CO2 flux. The CO2 influx in the ECS was twice that estimated for continental shelves worldwide, suggesting that the ECS acts as a strong sink of atmospheric CO2 compared to other continental shelves

Evaluation Indicators for Priorities of Standardization in Traditional Medicine: using Analytic Hierarchy Process(AHP)

The entire manuscript is available for download as a single PDF file. Higher-resolution images are unavailable. For assistance, please contact [email protected]. Fieldwork Team: Philippe Beaujard (Director of Research, French National Centre for Scientific Research). Technical Team: Dr. Vika Zafrin (Digital Scholarship Librarian, BU Libraries), Eleni Castro (OpenBU and Electronic Theses & Dissertations Librarian, BU Libraries), Dr. Fallou Ngom (Director of the African Studies Center), Dr. Peter Quella (Assistant Director, African Studies Center), Mustapha Hashim Kurfi (PhD Candidate, Department of Political Science), and Zachary Gersten (Research Assistant, African Studies Center). This collection of Malagasy Ajami materials is copied as part of the African Studies Center’s African Ajami Library. This project is partly funded by the BU African Studies Center. We thank Dr. Tim Longman, past Director of the African Studies Center, and the entire African Studies team for their support. For Inquiries: Please contact Professor Fallou Ngom ([email protected]).The material is the fourth part of the second of two texts copied and owned by Jean, a diviner-healer (called ombiasy in Malagasy). Jean belonged to the Anakara Clan and lived in a village called Vatomasina in the Antemoro region (in the valley of the Matatàña River). The original author of the material is unknown. The material was photographed between 1983 and 1990. The material was written on paper school notebooks. While the exact content of material is unknown, it is believed to contain guidance for charms, divination, and healing through prayers, geomancy, and astrology

Spitzer Spectral Mapping of Supernova Remnant Cassiopeia A

We present the global distribution of fine structure infrared line emission in the Cassiopeia A supernova remnant using data from the Spitzer Space Telescope's Infrared Spectrograph. We identify emission from ejecta materials in the interior, prior to their encounter with the reverse shock, as well as from the post-shock bright ring. The global electron density increases by >~100 at the shock to ~10^4 cm^-3, providing evidence for strong radiative cooling. There is also a dramatic change in ionization state at the shock, with the fading of emission from low ionization interior species like [SiII], giving way to [SIV] and, at even further distances, high-energy X-rays from hydrogenic silicon. Two compact, crescent-shaped clumps with highly enhanced neon abundance are arranged symmetrically around the central neutron star. These neon crescents are very closely aligned with the "kick" direction of the compact object from the remnant's expansion center, tracing a new axis of explosion asymmetry. They indicate that much of the apparent macroscopic elemental mixing may arise from different compositional layers of ejecta now passing through the reverse shock along different directions.Comment: 9 pages, 8 figures, accepted by Ap

Qualitative assessment of Tongue Drive System by people with high-level spinal cord injury

The Tongue Drive System (TDS) is a minimally invasive, wireless, and wearable assistive technology (AT) that enables people with severe disabilities to control their environments using tongue motion. TDS translates specific tongue gestures into commands by sensing the magnetic field created by a small magnetic tracer applied to the user’s tongue. We have previously quantitatively evaluated the TDS for accessing computers and powered wheelchairs, demonstrating its usability. In this study, we focused on its qualitative evaluation by people with high-level spinal cord injury who each received a magnetic tongue piercing and used the TDS for 6 wk. We used two questionnaires, an after-scenario and a poststudy, designed to evaluate the tongue-piercing experience and the TDS usability compared with that of the sip-and-puff and the users’ current ATs. After study completion, 73% of the participants were positive about keeping the magnetic tongue-barbell in order to use the TDS. All were satisfied with the TDS performance and most said that they were able to do more things using TDS than their current ATs (4.22/5)

Dietary calcium intake and the risk of colorectal cancer: a case control study

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Abstract Background High intake of dietary calcium has been thought to be a protective factor against colorectal cancer. To explore the dose-response relationship in the associations between dietary calcium intake and colorectal cancer risk by cancer location, we conducted a case-control study among Korean population, whose dietary calcium intake levels are relatively low. Methods The colorectal cancer cases and controls were recruited from the National Cancer Center in Korea between August 2010 and August 2013. Information on dietary calcium intake was assessed using a semi-quantitative food frequency questionnaire and locations of the colorectal cancers were classified as proximal colon cancer, distal colon cancer, and rectal cancer. Binary and polytomous logistic regression models were used to evaluate the association between dietary calcium intake and risk of colorectal cancer. Results A total of 922 colorectal cancer cases and 2766 controls were included in the final analysis. Compared with the lowest calcium intake quartile, the highest quartile group showed a significantly reduced risk of colorectal cancer in both men and women. (Odds ratio (OR): 0.16, 95 % confidence interval (CI): 0.11–0.24 for men; OR: 0.16, 95 % CI: 0.09–0.29 for women). Among the highest calcium intake groups, decrease in cancer risk was observed across all sub-sites of colorectum in both men and women. Conclusion In conclusion, calcium consumption was inversely related to colorectal cancer risk in Korean population where national average calcium intake level is relatively lower than Western countries. A decreased risk of colorectal cancer by calcium intake was observed in all sub-sites in men and women

Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case–control study

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.Abstract Background A remarkable increase in the number of thyroid cancer cases has been reported in recent years; however, the markers to predict high-risk groups have not been fully established. Methods We conducted a case–control study (257 cases and 257 controls) that was nested in the Cancer Screenee Cohort Study between August 2002 and December 2010; the mean follow-up time for this study was 3.1 ± 2.2 years. The levels of total triiodothyronine (TT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), anti-thyroperoxidase antibody (TPOAb), and anti-thyroglobulin antibody (TgAb) were measured using samples with pre-diagnostic status. Logistic regression models were used to examine the association between thyroid function/autoimmunity and thyroid cancer risk. Results When the markers were categorized by the tertile distributions of the control group, the highest tertile of FT4 (OR = 1.73, 95% CI = 1.11 - 2.69) and the middle tertile of TSH (OR = 1.77, 95% CI = 1.14 - 2.74) were associated with an increased risk of thyroid cancer by multivariate analyses. In addition, an elevated risk for thyroid cancer was found in subjects with TPOAb levels above 30 IU/mL (OR = 8.47, 95% CI = 5.39 - 13.33 for 30–60 IU/mL and OR = 4.48, 95% CI = 2.59 - 7.76 for ≥60 IU/mL). Stratified analyses indicated that some of these associations differed by sex, BMI, smoking status, and the duration of follow-up. Conclusions This study demonstrated that the levels of biomarkers of thyroid function/autoimmunity, particularly the presence of TPOAb, might be used as diagnostic markers for predicting thyroid cancer risk. Our findings suggest that careful monitoring of thyroid biomarkers may be helpful for identifying Korean populations at high-risk for thyroid cancer

Structure and mechanism of activity-based inhibition of the EGF-Receptor by Mig6

Mig6 is a feedback inhibitor that directly binds, inhibits and drives internalization of ErbB-family receptors. Mig6 selectivity targets activated receptors. Here we find that the EGF receptor phosphorylates Mig6 on Tyr394, and that this phosphorylation is primed by prior phosphorylation of an adjacent residue, Tyr395, by Src. Crystal structures of human EGFR–Mig6 complexes reveal the structural basis for enhanced phosphorylation of primed Mig6 and show how Mig6 rearranges after phosphorylation by EGFR to effectively irreversibly inhibit the same receptor that catalyzed its phosphorylation. This dual phosphorylation site allows Mig6 to inactivate EGFR in a manner that requires activation of the target receptor and can be modulated by Src. Loss of Mig6 is a driving event in human cancer; analysis of 1057 gliomas reveals frequent focal deletions of ERRFI, the gene that encodes Mig6, in EGFR-amplified glioblastomas