Financial social accounting matrix: concepts, constructions and theoretical framework

A Social Accounting Matrix (hereafter, SAM) is a particular tool to represent that whole economic activities incomes and expenditures flows accounts through a socio-economic system, which captures the transactions and transfers between all economic agents and institutions in the system. During the last two decades, the financial market are well developed and significantly impacts the economic growth, it will be more worthy to move from a real SAM to a Financial SAM, containing the details of the financial institutions and transaction of agents’ assets and liabilities. Therefore, this paper will discuss the outlines and constructions framework for the aggregate Financial SAM. The understanding of the structure of Financial SAM can be a database for a financial Computed General Equilibrium (CGE) model and can be used to analyze the behavior of national’s public debt.SOCIAL ACCOUNTING MATRIX (SAM), FINANCIAL, FLOW-OF-FUNDS

Yen synchronization among ASEAN-5, Korea and Japan: evidence from the multivariate GARCH model

In this study, we aim to investigate whether ASEAN-5 and the Korean currency regimes are ready to use Japanese Yen as an Asian future Exchange Rate Mechanism (AERM) by using Multivariate GARCH models. Overall findings show that Singapore, Thailand, and Korea are the potential countries that ready to adopt Japanese Yen as an AERM. However, Malaysian Ringgit, Indonesian Rupiah and the Philippines Peso are weakly correlated with Japanese Yen. This indicates that the East Asian free trade agreement such as ASEAN-10+3 and EAFTA does not enough to promote these low dynamic correlation countries (Malaysia, Indonesia, and the Philippines). Perhaps, the appropriate way to begin the AERM is to form a group of currency system which highly correlated with Japanese Yen (e.g. Singapore, Thailand, and Korea) whiles others could have a commitment to adopt Japanese Yen as a regional trade-invoicing currency in order to increase the level of Yen synchronization correlation

Impact of climate change and economic factors on Malaysian food price

This paper is motivated by the increasing food price over the recent years (2010 – 2017) in Malaysia. Food is a necessity for mankind and everyone has equal rights to enjoy adequate food protecting from hunger and malnutrition. In general, we understand that food and agriculture production are highly related. Crop production is affected biophysically by climatic variables, i.e. suitable rainfall and temperature for photosynthesis process to take place. If these climatic variables alter extremely in a long-term period, crop production will be affected and crop damage can occur due to the climate change effect such as extreme flood and drought. Hence, if climate change effect is defined as a linear relationship, it will result in a misleading explanation whereby as long as rainfall and temperature increase (or decrease) it will cause the crop production to decrease (or increase). Given the problem associated with food price, this paper investigated the food price determinants by looking at both economic factors and climate change. Non-linear time series analysis namely Engle-Granger (EG) cointegration test and Error Correction Mechanism (ECM) were performed by including the determinants such as Carbon Dioxide (CO2), crude oil price, exchange rate and real gross domestic product (RGDP). The results showed that both economic Real Gross Domestic Product and climate factors jointly affect food price significantly and climate factor (CO2) exhibits a strong non-linear U-shaped impact on food price in the long run. In addition, the Error Correction Term (ECT) showed that food market will have a slower self-recovery mechanism to adjust and return the temporary food market demand-supply shock to the equilibrium

LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells

The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment options. In particular, molecularly targeted therapies for hepatocellular carcinoma targeting cellular receptors and kinases have yielded disappointing clinical results, providing an urgency for targeting distinct mechanisms. LSF small molecule inhibitors, Factor Quinolinone Inhibitors (FQIs), have exhibited robust anti-tumor activity in multiple pre-clinical models of hepatocellular carcinoma, with no observable toxicity. To understand how the inhibitors impact cancer cell proliferation, we characterized the cellular phenotypes that result from loss of LSF activity. Phenotypically, inhibition of LSF activity induced a mitotic delay with condensed, but unaligned, chromosomes. This mitotic disruption resulted in improper cellular division leading to multiple outcomes: multi-nucleation, apoptosis, and cellular senescence. The cellular phenotypes observed upon FQI1 treatment were due specifically to the loss of LSF activity, as siRNA specifically targeting LSF produced nearly identical phenotypes. Taken together, these findings confirm that LSF is a promising therapeutic target for cancer treatment.First author draf

Perceptions of neighborhood social environment and drug dependence among incarcerated women and men: a cross-sectional analysis

Abstract Background Perception of neighborhood social environment can influence an individual’s susceptibility to drug dependence. However, this has never been examined with a jailed sample, where frequent transitions between local jails and disadvantaged neighborhoods are common. Understanding these associations could aid in the design of targeted programs to decrease drug dependence and recidivism among the incarcerated. Methods For this study, 596 women and men from three Kansas City jails were surveyed over the course of six months in 2010. Drug dependence was assessed with DSM-IV criteria. Independent variables included fear of one’s neighborhood, perceived level of neighborhood violence, and social capital. All data were self-reported and were analyzed using logistic regression. Results Controlling for gender and age, fear of neighborhood violence was associated with increased odds of having drug dependence (OR = 1.27, CI 1.02, 1.58) and a higher level of social capital prior to incarceration was associated with lower odds of drug dependence (OR = 0.65, CI 0.44, 0.96). Mental health problem diagnosis and past year intimate partner violence were significant mediating factors. Gender and race/ethnicity were significant moderating factors between neighborhood disadvantage and drug dependence. Conclusions Our study suggests that drug dependence programs for women and men who cycle between jails and communities require both individual- and community-level interventions. To be most effective, programs at the community-level should focus on helping specific groups navigate their communities, as well as address individual health needs associated with drug dependence.Peer Reviewe

Consumers' purchase intention towards genetically modified soybean products in Malaysia

In Malaysia, soybean products are a convenient and a popular daily food product, however, the main raw material used to produce these soybean products has been partly changed from the traditional soybean to the imported GM soybean. While the GM soybean products are commercially sold in the market, not all the consumers take notice or are aware of it. There is lack of information sharing between GM soybean products' producers and consumers and the argument about the safety of GM product is still a big issue among consumers. As the GMOs are relatively new to Malaysian consumers, the National Biotechnology Directorate is stepping up its efforts to implement public awareness programs on biotechnology. Thus, this study will attempt to conduct the consumer research to provide insights on how likely consumers are willing to purchase genetically modified soybean. The purpose of this study is to determine the factors affecting consumers' intention to purchase genetically modified soybean products in Malaysia. Multistage and convenient sampling was used in selecting 215 respondents who were surveyed using self-administered questionnaires. Descriptive analysis, reliability test, exploratory factor analysis and binary logistic regression analysis were used to accomplish the objective of this study. The binary logistic result shows that product attribute, consumer attitude, and gender influenced consumers' intention to purchase genetically modified soybean in Malaysia. Understanding the consumer's intention will help the food producer and manufacturer to identify the consumer preferences for GM food products and will help prevent losses in market share of soybean products

Disclosures of funding sources and conflicts of interest in published HIV/AIDS research conducted in developing countries

Objectives: Disclosures of funding sources and conflicts of interests (COI) in published peer-reviewed journal articles have recently begun to receive some attention, but many critical questions remain, for example, how often such reporting occurs concerning research conducted in the developing world and what factors may be involved. Design: Of all articles indexed in Medline reporting on human subject HIV research in 2007 conducted in four countries (India, Thailand, Nigeria and Uganda), this study explored how many disclosed a funding source and COI, and what factors are involved. Results: Of 221 articles that met the criteria, 67.9% (150) disclosed the presence or absence of a funding source, but only 20% (44) disclosed COI. Studies from Uganda were more likely, and those from Nigeria were less likely to mention a funding source (p<0.001). Of articles in journals that had adopted International Committee of Medical Journal Editors (ICMJE) guidelines, 56% did not disclose COI. Disclosure of funding was more likely when: ≥50% of the authors and the corresponding author were from the sponsoring country, the sponsor country was the USA, and the articles were published in journals in which more of the editors were from the sponsoring countries. Conclusions: Of the published studies examined, over a third did not disclose funding source (ie, whether or not there was a funding source) and 80% did not disclose whether COI existed. Most articles in ICMJE-affiliated journals did not disclose COI. These data suggest the need to consider alteration of policies to require that published articles include funding and COI information, to allow readers to assess articles as fully as possible