XMM-Newton view of the N 206 superbubble in the Large Magellanic Cloud

We perform an analysis of the X-ray superbubble in the N 206 HII region in the Large Magellanic Cloud using current generation facilities to gain a better understanding of the physical processes at work in the superbubble and to improve our knowledge of superbubble evolution. We used XMM-Newton observations of the N 206 region to produce images and extract spectra of the superbubble diffuse emission. Morphological comparisons with Halpha images from the Magellanic Cloud Emission Line Survey were performed, and spectral analysis of the diffuse X-ray emission was carried out. We derived the physical properties of the hot gas in the superbubble based on the results of the spectral analysis. We also determined the total energy stored in the superbubble and compared this to the expected energy input from the stellar population to assess the superbubble growth rate discrepancy for N 206. We find that the brightest region of diffuse X-ray emission is confined by a Halpha shell, consistent with the superbubble model. In addition, faint emission extending beyond the Halpha shell was found, which we attribute to a blowout region. The spectral analysis of both emission regions points to a hot shocked gas as the likely origin of the emission. We determine the total energy stored in the bubble and the expected energy input by the stellar population. However, due to limited data on the stellar population, the input energy is poorly constrained and, consequently, no definitive indication of a growth rate discrepancy is seen. Using the high-sensitivity X-ray data from XMM-Newton and optical data from the Magellanic Cloud Emission Line Survey has allowed us to better understand the physical properties of the N 206 superbubble and address some key questions of superbubble evolution.Comment: 12 pages, 7 figures. Accepted for publication in A&

Digging for Dark Matter: Spectral Analysis and Discovery Potential of Paleo-Detectors

Paleo-detectors are a recently proposed method for the direct detection of Dark Matter (DM). In such detectors, one would search for the persistent damage features left by DM--nucleus interactions in ancient minerals. Initial sensitivity projections have shown that paleo-detectors could probe much of the remaining Weakly Interacting Massive Particle (WIMP) parameter space. In this paper, we improve upon the cut-and-count approach previously used to estimate the sensitivity by performing a full spectral analysis of the background- and DM-induced signal spectra. We consider two scenarios for the systematic errors on the background spectra: i) systematic errors on the normalization only, and ii) systematic errors on the shape of the backgrounds. We find that the projected sensitivity is rather robust to imperfect knowledge of the backgrounds. Finally, we study how well the parameters of the true WIMP model could be reconstructed in the hypothetical case of a WIMP discovery.Comment: 14 pages, 5 figures, code available at https://github.com/tedwards2412/paleo_detectors/ . v2: Added additional analysis theory details, matches version published in PR

Effect of Pre-and Post-weaning Nutrition and Management on Performance of Weaned Pigs to circa 35 kg.

End of Project ReportThe objective of this project was to examine the factors affecting performance (growth rate, appetite, feed conversion efficiency) of pigs in the stage from weaning to 35 kg liveweight. The study involved three stages, creep feeding during the suckling period, management during the first weaner stage (c. 4 weeks from weaning or 6 kg to 15 kg liveweight) and management during the second weaner stage (c. 15 kg to 35 kg liveweight. Creep feed intake before weaning was low c. 2.5 to 3.0 kg per litter but where it was consumed the response in terms of feed conversion efficiency was good with litter weight increasing in weight by about 1.1 kg for each 1 kg creep consumed. Milk replacer in liquid form was very readily consumed but its preparation and feeding is very laborious. Weaning weight was poorly related to post weaning performance and weaning age seemed to be more critical which is probably a reflection of the greater maturity of older animals. In the first weaner stage, feeding of cooked cereal containing diets was found to have little benefit in pig performance. Acidification of feeds is likely to have only a minor influence on pig performance. An experiment on choice feeding of starter and link feeds did not confirm that smaller pigs require a higher quality diet and, in a choice situation will eat a greater proportion of the more nutrient dense diet. In the second weaner stage, comparison of three commercial weaner feeds with a cereal based control diet showed good performance on all four diets. Pigs fed a high lysine weaner diet grew better in the weaner stage but by slaughter those pigs fed the low lysine weaner diet, after all pigs were fed a common finisher diet, had overtaken them. The high lysine group did, however, have leaner carcasses. Residual effects of early nutrition need to be investigated in more detail including the effect of pregnancy feeding on prenatal development and the relationship between prenatal growth and postnatal growth, in particular development of muscle.European Union Structural Funds (EAGGF

Paleo-Detectors for Galactic Supernova Neutrinos

Paleo-detectors are a proposed experimental technique in which one would search for traces of recoiling nuclei in ancient minerals. Natural minerals on Earth are as old as $\mathcal{O}(1)\,$Gyr and, in many minerals, the damage tracks left by recoiling nuclei are also preserved for timescales long compared to 1 Gyr once created. Thus, even reading out relatively small target samples of order 100 g, paleo-detectors would allow one to search for very rare events thanks to the large exposure, $\varepsilon \sim 100\,{\rm g}\,{\rm Gyr} = 10^5\,{\rm t}\,{\rm yr}$. Here, we explore the potential of paleo-detectors to measure nuclear recoils induced by neutrinos from galactic core collapse supernovae. We find that they would not only allow for a direct measurement of the average core collapse supernova rate in the Milky Way, but would also contain information about the time-dependence of the local supernova rate over the past $\sim$1 Gyr. Since the supernova rate is thought to be directly proportional to the star formation rate, such a measurement would provide a determination of the local star formation history. We investigate the sensitivity of paleo-detectors to both a smooth time evolution and an enhancement of the core collapse supernova rate on relatively short timescales, as would be expected for a starburst period in the local group.Comment: 15 pages, 5 figures. code available at https://github.com/tedwards2412/SN-paleology (archived at https://doi.org/10.5281/zenodo.3066206 ) v2: matches the published versio

Multi-frequency study of DEM L299 in the Large Magellanic Cloud

We have studied the HII region DEM L299 in the Large Magellanic Cloud to understand its physical characteristics and morphology in different wavelengths. We performed a spectral analysis of archived XMM-Newton EPIC data and studied the morphology of DEM L299 in X-ray, optical, and radio wavelengths. We used H alpha, [SII], and [OIII] data from the Magellanic Cloud Emission Line Survey and radio 21 cm line data from the Australia Telescope Compact Array (ATCA) and the Parkes telescope, and radio continuum data from ATCA and the Molonglo Synthesis Telescope. Our morphological studies imply that, in addition to the supernova remnant SNR B0543-68.9 reported in previous studies, a superbubble also overlaps the SNR in projection. The position of the SNR is clearly defined through the [SII]/H alpha flux ratio image. Moreover, the optical images show a shell-like structure that is located farther to the north and is filled with diffuse X-ray emission, which again indicates the superbubble. Radio 21 cm line data show a shell around both objects. Radio continuum data show diffuse emission at the position of DEM L299, which appears clearly distinguished from the HII region N 164 that lies south-west of it. We determined the spectral index of SNR B0543-68.9 to be alpha=-0.34, which indicates the dominance of thermal emission and therefore a rather mature SNR. We determined the basic properties of the diffuse X-ray emission for the SNR, the superbubble, and a possible blowout region of the bubble, as suggested by the optical and X-ray data. We obtained an age of 8.9 (3.5-18.1) kyr for the SNR and a temperature of 0.64 (0.44-1.37) keV for the hot gas inside the SNR, and a temperature of the hot gas inside the superbubble of 0.74 (0.44-1.1) keV. We conclude that DEM L299 consists of a superposition of SNR B0543-68.9 and a superbubble, which we identified based on optical data.Comment: Accepted for publication in Astronomy and Astrophysics. 17 pages, 16 figure

Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats

AbstractWnt activation by inhibiting glycogen synthase kinase 3 (GSK-3) causes bone anabolism in rodents making GSK-3 a potential therapeutic target for osteoporotic and osteolytic metastatic bone disease. To understand the wnt pathway related to human disease translation, the ability of 3 potent inhibitors of GSK-3 (AZD2858, AR79, AZ13282107) to 1) drive osteoblast differentiation and mineralisation using human adipose-derived stem cells (hADSC) in vitro; and 2) stimulate rat bone formation in vivo was investigated. Bone anabolism/resorption was determined using clinically relevant serum biomarkers as indicators of bone turnover and bone formation assessed in femurs by histopathology and pQCT/μCT imaging.GSK-3 inhibitors caused β-catenin stabilisation in human and rat mesenchymal stem cells, stimulated hADSC commitment towards osteoblasts and osteogenic mineralisation in vitro. AZD2858 produced time-dependent changes in serum bone turnover biomarkers and increased bone mass over 28days exposure in rats. After 7days, AZD2858, AR79 or AZ13282107 exposure increased the bone formation biomarker P1NP, and reduced the resorption biomarker TRAcP-5b, indicating increased bone anabolism and reduced resorption in rats. This biomarker profile was differentiated from anabolic agent PTH1–34 or the anti-resorptive Alendronate-induced changes. Increased bone formation in cortical and cancellous bone as assessed by femur histopathology supported biomarker changes. 14 day AR79 treatment increased bone mineral density and trabecular thickness, and decreased trabecular number and connectivity assessed by pQCT/μCT.GSK-3 inhibition caused hADSC osteoblastogenesis and mineralisation in vitro. Increased femur bone mass associated with changes in bone turnover biomarkers confirmed in vivo bone formation and indicated uncoupling of bone formation and resorption

A JWST/MIRI and NIRCam Analysis of the Young Stellar Object Population in the Spitzer I region of NGC 6822

We present an imaging survey of the Spitzer~I star-forming region in NGC 6822 conducted with the NIRCam and MIRI instruments onboard JWST. Located at a distance of 490 kpc, NGC 6822 is the nearest non-interacting low-metallicity ($\sim$0.2 $Z_{\odot}$) dwarf galaxy. It hosts some of the brightest known HII regions in the local universe, including recently discovered sites of highly-embedded active star formation. Of these, Spitzer I is the youngest and most active, and houses 90 color-selected candidate young stellar objects (YSOs) identified from Spitzer Space Telescope observations. We revisit the YSO population of Spitzer~I with these new JWST observations. By analyzing color-magnitude diagrams (CMDs) constructed with NIRCam and MIRI data, we establish color selection criteria and construct spectral energy distributions (SEDs) to identify candidate YSOs and characterize the full population of young stars, from the most embedded phase to the more evolved stages. In this way, we have identified 129 YSOs in Spitzer I. Comparing to previous Spitzer studies of the NGC 6822 YSO population, we find that the YSOs we identify are fainter and less massive, indicating that the improved resolution of JWST allows us to resolve previously blended sources into individual stars.Comment: 17 pages, 9 figures, 2 tables, to be submitted to ApJ, comments welcom

The nature of point source fringes in mid-infrared spectra acquired with the James Webb Space Telescope

The constructive and destructive interference in different layers of the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) detector arrays modulate the detected signal as a function of wavelength. Additionally, sources of different spatial profiles show different fringe patterns. Dividing by a static fringe flat could hamper the scientific interpretation of sources whose fringes do not match that of the fringe flat. We find point source fringes measured by the MIRI Medium-Resolution Spectrometer (MRS) to be reproducible under similar observing conditions. We want, thus, to identify the variables, if they exist, that would allow for a parametrization of the signal variations induced by point source fringe modulations. We do this by analyzing MRS detector plane images acquired on the ground. We extracted the fringe profile of multiple point source observations and studied the amplitude and phase of the fringes as a function of field position and pixel sampling of the point spread function of the optical chain. A systematic variation in the amplitude and phase of the point source fringes is found over the wavelength range covered by the test sources (4.9-5.8 $\mu$m). The variation depends on the fraction of the point spread function seen by the detector pixel. We identify the non-uniform pixel illumination as the root cause of the reported systematic variation. We report an improvement after correction of 50% on the 1$\sigma$ standard deviation of the spectral continuum. A 50% improvement is also reported in line sensitivity for a benchmark test with a spectral continuum of 100 mJy. The improvement in the shape of weak lines is illustrated using a T Tauri model spectrum. Consequently, we verify that fringes of extended sources and potentially semi-extended sources and crowded fields can be simulated by combining multiple point source fringe transmissions.Comment: 17 pages, 31 figure

Deep XMM-Newton observations of the northern disk of M31 II: Tracing the hot interstellar medium

Aims: We use new deep XMM-Newton observations of the northern disk of M 31 to trace the hot interstellar medium (ISM) in unprecedented detail and to characterise the physical properties of the X-ray emitting plasmas. Methods: We used all XMM-Newton data up to and including our new observations to produce the most detailed image yet of the hot ISM plasma in a grand design spiral galaxy such as our own. We compared the X-ray morphology to multi-wavelength studies in the literature to set it in the context of the multi-phase ISM. We performed spectral analyses on the extended emission using our new observations as they offer sufficient depth and count statistics to constrain the plasma properties. Data from the Panchromatic Hubble Andromeda Treasury were used to estimate the energy injected by massive stars and their supernovae. We compared these results to the hot gas properties. Results: The brightest emission regions were found to be correlated with populations of massive stars, notably in the 10 kpc star-forming ring. The plasma temperatures in the ring regions are ~0.2 keV up to ~0.6 keV. We suggest this emission is hot ISM heated in massive stellar clusters and superbubbles. We derived X-ray luminosities, densities, and pressures for the gas in each region. We also found large extended emission filling low density gaps in the dust morphology of the northern disk, notably between the 5 kpc and 10 kpc star-forming rings. We propose that the hot gas was heated and expelled into the gaps by the populations of massive stars in the rings. Conclusions. It is clear that the massive stellar populations are responsible for heating the ISM to X-ray emitting temperatures, filling their surroundings, and possibly driving the hot gas into the low density regions. Overall, the morphology and spectra of the hot gas in the northern disk of M 31 is similar to other galaxy disks.Comment: 23 pages, 14 figures, accepted for publication in Astronomy & Astrophysic