Drag Force Scaling for Penetration Into Granular Media

Impact dynamics is measured for spherical and cylindrical projectiles of many different densities dropped onto a variety non-cohesive granular media. The results are analyzed in terms of the material-dependent scaling of the inertial and frictional drag contributions to the total stopping force. The inertial drag force scales similar to that in fluids, except that it depends on the internal friction coefficient. The frictional drag force scales as the square-root of the density of granular medium and projectile, and hence cannot be explained by the combination of granular hydrostatic pressure and Coulomb friction law. The combined results provide an explanation for the previously observed penetration depth scaling

Avalanche statistics and time-resolved grain dynamics for a driven heap

We probe the dynamics of intermittent avalanches caused by steady addition of grains to a quasi-two dimensional heap. To characterize the time-dependent average avalanche flow speed v(t), we image the top free surface. To characterize the grain fluctuation speed dv(t), we use Speckle-Visibility Spectroscopy. During an avalanche, we find that the fluctuation speed is approximately one-tenth the average flow speed, and that these speeds are largest near the beginning of an event. We also find that the distribution of event durations is peaked, and that event sizes are correlated with the time interval since the end of the previous event. At high rates of grain addition, where successive avalanches merge into smooth continuous flow, the relationship between average and fluctuation speeds changes to dv Sqrt[v]

Sinusoidal fetal heart rate pattern

We describe 2 cases of term anemic fetuses with different sinusoidal pattern morphology, and possible mechanisms.nbspCasesmdashThe first patient noted sudden cessation of fetal movement on the day of presentation. She had a sinusoidal FHR pattern. The newborn had a hemoglobin of 3.7 g/dl, and umbilical artery pH was 7.10 and BE -7 mEq/l. The second patient noted decreased fetal movement for several days. She had a FHR pattern with absent FHR variability, and intermittent sinusoidal elements, with late decelerations. The newbornrsquos hemoglobin was 1.5 g/dl, umbilical artery pH was 7.07 and BE -10.2 mEq/l. Both cases had positive Kleihauer-Betke tests

Classification of KPZQ and BDP models by multiaffine analysis

We argue differences between the Kardar-Parisi-Zhang with Quenched disorder (KPZQ) and the Ballistic Deposition with Power-law noise (BDP) models, using the multiaffine analysis method. The KPZQ and the BDP models show mono-affinity and multiaffinity, respectively. This difference results from the different distribution types of neighbor-height differences in growth paths. Exponential and power-law distributions are observed in the KPZQ and the BDP, respectively. In addition, we point out the difference of profiles directly, i.e., although the surface profiles of both models and the growth path of the BDP model are rough, the growth path of the KPZQ model is smooth.Comment: 11 pages, 6 figure

Asymptotic function for multi-growth surfaces using power-law noise

Numerical simulations are used to investigate the multiaffine exponent $\alpha_q$ and multi-growth exponent $\beta_q$ of ballistic deposition growth for noise obeying a power-law distribution. The simulated values of $\beta_q$ are compared with the asymptotic function $\beta_q = \frac{1}{q}$ that is approximated from the power-law behavior of the distribution of height differences over time. They are in good agreement for large $q$. The simulated $\alpha_q$ is found in the range $\frac{1}{q} \leq \alpha_q \leq \frac{2}{q+1}$. This implies that large rare events tend to break the KPZ universality scaling-law at higher order $q$.Comment: 5 pages, 4 figures, to be published in Phys. Rev.

Projectile interactions in granular impact cratering

We present evidence for the interactions between a ball and the container boundaries, as well as between two balls, that are mediated by the granular medium during impact cratering. The presence of the bottom boundary affects the final penetration depth only for low drop heights with shallow filling, in which case, surprisingly, the penetration becomes deeper. By contrast the presence of the side wall causes less penetration and also an effective repulsion. Repulsion is also found for two balls dropped side-by-side

A Novel Sensitive Immunoassay Targeting the 5-Methylthio-d-Xylofuranose-Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis.

The only currently commercialized point-of-care assay for tuberculosis (TB) that measures lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient sensitivity. We evaluated the potential of 100 novel monoclonal antibody pairs targeting a variety of LAM epitopes on a sensitive electrochemiluminescence platform to improve the diagnostic accuracy. In the screening, many antibody pairs showed high reactivity to purified LAM but performed poorly at detecting urinary LAM in clinical samples, suggesting differences in antigen structure and immunoreactivity of the different LAM sources. The 12 best antibody pairs from the screening were tested in a retrospective case-control study with urine samples from 75 adults with presumptive TB. The best antibody pair reached femtomolar analytical sensitivity for LAM detection and an overall clinical sensitivity of 93% (confidence interval [CI], 80% to 97%) and specificity of 97% (CI, 85% to 100%). Importantly, in HIV-negative subjects positive for TB by sputum smear microscopy, the test achieved a sensitivity of 80% (CI, 55% to 93%). This compares to an overall sensitivity of 33% (CI, 20% to 48%) of the Alere LF-LAM and a sensitivity of 13% (CI, 4% to 38%) in HIV-negative subjects in the same sample set. The capture antibody targets a unique 5-methylthio-d-xylofuranose (MTX)-dependent epitope in LAM that is specific to the Mycobacterium tuberculosis complex and shows no cross-reactivity with fast-growing mycobacteria or other bacteria. The present study provides evidence that improved assay methods and reagents lead to increased diagnostic accuracy. The results of this work have informed the development of a sensitive and specific novel LAM point-of-care assay with the aim to meet the WHO's performance target for TB diagnosis