Penggunaan Tenaga Kerja Asing Oleh Perseroan Terbatas Penanam Modal Asing Yang Berinvestasi Di Indonesia

A number of foreign workers who are currently working in Indonesia is not in accordance with the legislation that exists. The foreign workers doing menial jobs and do not have immigration documents are complete. They are working on a number of foreign investors in a number of business sectors, especially in construction and infrastructure. The type of research that is done is the normative legal research i.e. Research which focuses on positive form of legal norms and regulations. Types of data used include primary law, secondary legal materials and legal materials tertiary. The use of foreign labor by a limited liability foreign investors who invest in Indonesia must comply with the legislation that exists. The foreign workers are only allowed to occupy positions as commissioners, directors, and experts who are accompanied by a complete immigration administrative documents

緊急事態宣言時における武庫川女子大学子育てひろばの取り組み

　本研究の目的は，緊急事態宣言時における武庫川女子大学子育てひろばの取り組みを紹介することである。2020 年3月3 日～5 月29 日の期間，武庫川女子大学子育てひろばは新型コロナウイルス感染症予防や政府の緊急事態宣言のため臨時休館した。臨時休館中は地域の子育て家庭は来館できないため，武庫川女子大学子育てひろばは，地域の子育て家庭に向けて，①子育てひろば利用者への手紙の発送，②子育てひろば職員による電話での子育て相談，③SNS（Facebook）を通じた支援，を実施した。今後の課題として，①これらの取り組みの効果検証の実施，②再び休館した際のさらなる取り組みの検討，③子育てひろば再開後の事業展開のあり方，が挙げられた

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

Impact of the HCRTR2 gene risk variant on schizotypal personality traits (mean ± SD). (DOC 54 kb

FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

乳がんの再発を起こす原因細胞を解明. 京都大学プレスリリース. 2023-11-16.The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity, we undertook single-cell transcriptomics analysis in triple-negative breast cancer (TNBC) to identify subpopulations in CSCs. We found a subpopulation of CSCs with ancestral features that is marked by FXYD domain–containing ion transport regulator 3 (FXYD3), a component of the Na⁺/K⁺ pump. Accordingly, FXYD3⁺ CSCs evolve and proliferate, while displaying traits of alveolar progenitors that are normally induced during pregnancy. Clinically, FXYD3⁺ CSCs were persistent during neoadjuvant chemotherapy, hence linking them to drug-tolerant persisters (DTPs) and identifying them as crucial therapeutic targets. Importantly, FXYD3⁺ CSCs were sensitive to senolytic Na⁺/K⁺ pump inhibitors, such as cardiac glycosides. Together, our data indicate that FXYD3⁺ CSCs with ancestral features are drivers of plasticity and chemoresistance in TNBC. Targeting the Na⁺/K⁺ pump could be an effective strategy to eliminate CSCs with ancestral and DTP features that could improve TNBC prognosis