EFFICACY OF ANANDA YOGA CHURNA IN THE MANAGEMENT OF MOOTRASHMARI (UROLITHIASIS) - A CLINICAL STUDY

According to modern science, the formation of stone in urinary system is one of the main problems of urology. The cause and mechanism of their formation is still uncertain. On one hand surprisingly stone does not always form when such factors are present and on the other hand stones may develop when factors are apparently absent too. Treatment of calculi in modern science is only surgery and very less medicines are available for this purpose. After surgery, the probability of reoccurrence of calculi is same as previously, so it is negative aspect of this science. But in ancient medical, after treatment and removal of stone, the chances of recurrence are rarely occurs. In this research work, subjective symptoms like pain, burning micturiton, haematuria, dysurea, tenderness and fever are reduced very significantly and their recurrence does not occurs during trial of drug. Maximum patients belong to the category of renal and ureter culculi and efficacy of drug are also maximum observe on renal and as well as ureter. On the basis of size of calculi i.e. 6 mm to >10 mm, the efficacy of drug are also observed and result exhibited as 66 percent to 100 percent. So, the overall result in this research work is that, 72 % patients are cured, 20% patients are improved and only 8% patients are unchanged. Hence, the classical medicine Anand yoga churna for Mutrashmari is best the medicine because its efficacy is very significant on both subjective and objective parameters, cast effective, easy availability and also removed the negative aspect of modern medical science i.e. recurrence of calculi.

ANTI-OXIDANT POTENTIAL OF BAEL {AEGLE MARMELOS (L) CORR} FRUIT IN EXPERIMENTAL GASTRIC ULCERATED RAT

The present investigation of unripe fruit of A. marmelos was done to the study their antioxidant and free radical scavenger activity in experimental gastric ulcerated animals. The rats were given EtOH extract of herbal drug Aegle marmelos fruit extract (50 to 200 mg/kg) and control drug ranitidine (50 mg/kg) orally, twice daily for 5 days and on day 6 of experiment, 1 hour prior to subjecting the animal to stress or necrotizing concentration of respective irritants. Rats were then subjected to CRS in the absence and presence of cytoprotective irritant or herbal drugs. The fundic part of the stomach is homogenized (5%) in ice cold 0.9% saline with a Potter-Elvehjem glass homogenizer for 30 sec. the homogenate were centrifuged at 8,000 rpm for 10 min followed by centrifugation of the supernatant at 12000 rpm for 15 min in a sigma laboratory centrifuges 3K30 and the obtained mitochondrial fraction and further this fraction was used for the estimation of LPO product malondialdehyde. Further SOD and CAT was estimated.The study revealed that the 50% fruit extract dose dependently protected the oxidative stress and showed a tendency to decrease in volume acid-pepsin concentration and output. Reference drug rantidine a known cytoprotective agent has little effect on volume acid and pepsin concentration and acid output but showed a significant reduced in peptic output reduced LPO level and increase SOD and CAT level. The outcome indicate that the 50% ethanolic extract of A. marmelos fruit might have protected the rat tissues from ASP, PL, CRS and alcohol induced oxidative stress through anti-oxidant mechanism

CONVENTIONAL TAXONOMY AND TREATMENT ETIQUETTE OF KAMALA W.S.R.TO MODE OF ACTION OF NAVAYAS LAUHA CHURNA ON SHAKHASHRIT KAMALA (HEPATO-CELLULAR JAUNDICE)

The scientific taxonomy of disease make easy to study, recognition of etiology, diagnosis and planning of treatment of any ailment. The traditional cataloging of diseases have been described in traditional system of medicine is very scientific as well as practical also. Like classification of other ailment, Kamala has been classified basically in various groups like Koshthashrita (haemolytic jaundice) & Shakhashrita (hepato-cellular jaundice), Swatantra (independent) and Partantra (manifest as a complication of another disease), Bahupitta (due to excess generation of bilirubin) and Alpapitta (due to retention of bilirubin). But in this article, the elaborated taxonomy of Kamala is described on the behalf of four types of Samprapti i.e. Vidhi, Vikalpa, Pradhanya and Bala which have great importance in diagnosis and management of Kamala ailment. Everyone knows that abolition of etiology and cleavage of pathological chain of ailment is the steady and complete healing of disease. The treatment protocol of Kamala is entirely based on this theory. There are two segment of treatment of Kamala, first is nonspecific which is common and applicable for all kinds of Kamala and second is specific treatment which is explicit for definite types of Kamala. In Ayurvedic pharmacology, the mode action of drugs and how to cleavage the pathogenesis of ailment is not described but here it is illustrated very clearly and in a mannered way. The Navayas lauha churna has three groups of herbal drugs i.e. Trimada, Trikatu and Triphala and one group of Lauha bhasma. Each groups of drugs of this medicine; where (at which step of pathogenesis) and how to act and cleavage the pathogenesis of Shakhashrita kamal (hepato-cellular jaundice) are narrated with scientific, logical and evidence based discussion and as well as institution of liaison with contemporary science

Supramolecular catalysis in the synthesis of polyfunctionalised pyrroles

<div><p>An efficient sequential one pot three component reaction involving anilines, DEAD/DMAD and glyoxal in aqueous media is reported. The protocol is environmentally benign and provides a new synthetic route to access polyfunctionalised pyrrole derivatives in high yield. The reaction proceeded via supramolecular catalysis.</p></div

Triphenylphosphine-Catalyzed, Novel, One-Pot, Multicomponent Synthesis of Functionalized β-Acetamido Carbonyls

<div><p></p><p>An efficient triphenylphosphine-catalyzed synthesis of β-acetamido carbonyls via multicomponent reaction of aromatic aldehydes, enolizable ketones or β-keto esters, acid chlorides and acetonitrile at room temperature is described. The process is remarkably simple, environmentally benign, and uses Lewis base for the first time in such type of reaction.</p> </div