Supramolecular catalysis in the synthesis of polyfunctionalised pyrroles

Abstract

<div><p>An efficient sequential one pot three component reaction involving anilines, DEAD/DMAD and glyoxal in aqueous media is reported. The protocol is environmentally benign and provides a new synthetic route to access polyfunctionalised pyrrole derivatives in high yield. The reaction proceeded via supramolecular catalysis.</p></div