36,790 research outputs found
Protein transduction: A novel tool for tissue regeneration
Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the risk of cancer formation a protein therapy approach has been developed. The transient delivery of proteins rather than genes could still induce terminallydifferentiated cells to reenter the cell cycle. This approach takes advantage of proteintransducing domains that mediate the transfer of cargo proteins into cells. The goal of this brief review is to outline the basics of protein transduction and to discuss potential applications for tissue regeneration
Double Phase Transitions in Magnetized Spinor Bose-Einstein Condensation
It is investigated theoretically that magnetized Bose-Einstein condensation
(BEC) with the internal (spin) degrees of freedom exhibits a rich variety of
phase transitions, depending on the sign of the interaction in the spin
channel. In the antiferromagnetic interaction case there exist always double
BEC transitions from single component BEC to multiple component BEC. In the
ferromagnetic case BEC becomes always unstable at a lower temperature, leading
to a phase separation. The detailed phase diagram for the temperature vs the
polarization, the spatial spin structure, the distribution of non-condensates
and the excitation spectrum are examined for the harmonically trapped systems.Comment: 6 pages, 7 figures. Submitted to J. Phys. Soc. Jp
A large accretion disk of extreme eccentricity in the TDE ASASSN-14li
In the canonical model for tidal disruption events (TDEs), the stellar debris
circularizes quickly to form an accretion disk of size about twice the orbital
pericenter of the star. Most TDEs and candidates discovered in the optical/UV
have broad optical emission lines with complex and diverse profiles of puzzling
origin. Liu et al. recently developed a relativistic elliptical disk model of
constant eccentricity in radius for the broad optical emission lines of TDEs
and well reproduced the double-peaked line profiles of the TDE candidate
PTF09djl with a large and extremely eccentric accretion disk. In this paper, we
show that the optical emission lines of the TDE ASASSN-14li with radically
different profiles are well modelled with the relativistic elliptical disk
model, too. The accretion disk of ASASSN-14li has an eccentricity 0.97 and
semimajor axis of 847 times the Schwarzschild radius (r_S) of the black hole
(BH). It forms as the consequence of tidal disruption of a star passing by a
massive BH with orbital pericenter 25r_S. The optical emission lines of
ASASSN-14li are powered by an extended X-ray source of flat radial distribution
overlapping the bulk of the accretion disk and the single-peaked asymmetric
line profiles are mainly due to the orbital motion of the emitting matter
within the disk plane of inclination about 26\degr and of pericenter
orientation closely toward the observer. Our results suggest that modelling the
complex line profiles is powerful in probing the structures of accretion disks
and coronal X-ray sources in TDEs.Comment: 10 pages, 8 figures, accepted for publication in the MNRA
Topological Excitations in Spinor Bose-Einstein Condensates
We investigate the properties of skyrmion in the ferromagnetic state of
spin-1 Bose-Einstein condensates by means of the mean-field theory and show
that the size of skyrmion is fixed to the order of the healing length. It is
shown that the interaction between two skyrmions with oppositely rotating spin
textures is attractive when their separation is large, following a unique
power-law behavior with a power of -7/2.Comment: 4 pages, 5 figure
Two--Electron Atoms in Short Intense Laser Pulses
We discuss a method of solving the time dependent Schrodinger equation for
atoms with two active electrons in a strong laser field, which we used in a
previous paper [A. Scrinzi and B. Piraux, Phys. Rev. A 56, R13 (1997)] to
calculate ionization, double excitation and harmonic generation in Helium by
short laser pulses. The method employs complex scaling and an expansion in an
explicitly correlated basis. Convergence of the calculations is documented and
error estimates are provided. The results for Helium at peak intensities up to
10^15 W/cm^2 and wave length 248 nm are accurate to at least 10 %. Similarly
accurate calculations are presented for electron detachment and double
excitation of the negative hydrogen ion.Comment: 14 pages, including figure
A survey of the treatment and management of patients with severe chronic spontaneous urticaria.
Chronic spontaneous urticaria (CSU) is characterized by the recurrent appearance of weals, angioâoedema or both, occurring at least twice weekly for longer than 6 weeks.1 It is often managed with antihistamines, but occasionally requires other systemic agents in recalcitrant cases.
A crossâsectional survey was conducted by means of an internetâbased survey tool (Typeform; https://www.typeform.com). Participating consultants with a specialist interest in urticaria were identified through the specialist registers of the British Society of Allergy and Clinical Immunology (BSACI), the Improving Quality in Allergy Services (IQAS) Group and the British Association of Dermatologists (BAD), and invited to take part.
The survey content was based on current CSU treatment guidelines from EAACI/GA2LEN/EDF/WAO1 and the British Society for Allergy and Clinical Immunology (BSACI).2 The EAACI/GA2LEN/EDF/WAO guidelines are a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA2LEN) (a European Unionâfunded network of excellence), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO). To standardize responses, all participants were presented with a case of recalcitrant CSU (failed on maximum dose of nonsedating antihistamines and montelukast), requiring alternative systemic treatment. Questions covered usage of systemic treatments, routine disease severity assessments, adherence to treatment guidelines and perceived barriers to prescribing.
Responses (Table 1) were received from 19 UK consultants (26 surveys sent; completion rate 73%), 15 of whom had > 10 yearsâ experience in the treatment of CSU. The majority were allergy (58%) and dermatology consultants (37%). Of the 19 consultants, 56% provide a dedicated urticaria service, 37% treat both adult and paediatric patients, and the majority (79%) use systemic medications other than antihistamines and montelukast. Omalizumab and ciclosporin were the most commonly used firstâline agents (47% and 27% respectively) (Fig. 1). The majority (84%) of consultants use validated measures to assess disease severity, including the weekly Urticaria Activity Score (UASâ7, 63%), the Physician Global Assessment (63%), the Patient Global Assessment (44%) and the Dermatology Quality of Life Index (DLQI) (38%). Guidelines are used by 89% to direct their management of CSU, with 50% using the EAACI/GA2LEN/EDF/WAO guideline,1 compared with 31% primarily using the BSACI guideline.2 The main perceived barriers to prescribing systemic medications were potential adverse effects (AEs) (32% strongly agreed), potential longâterm toxicity (26% strongly agreed), cost of treatment (42% strongly agreed), and views expressed by the patient and their family (37% agreed)
Atomic entanglement near a realistic microsphere
We study a scheme for entangling two-level atoms located close to the surface
of a dielectric microsphere. The effect is based on medium-assisted spontaneous
decay, rigorously taking into account dispersive and absorptive properties of
the microsphere. We show that even in the weak-coupling regime, where the
Markov approximation applies, entanglement up to 0.35 ebits between two atoms
can be created. However, larger entanglement and violation of Bell's inequality
can only be achieved in the strong-coupling regime.Comment: 16 pages, 4 figures, Late
A view of the narrow-line region in the infrared: active galactic nuclei with resolved fine-structure lines in the Spitzer archive
We queried the Spitzer archive for high-resolution observations with the
Infrared Spectrograph of optically selected active galactic nuclei (AGN) for
the purpose of identifying sources with resolved fine-structure lines that
would enable studies of the narrow-line region (NLR) at mid-infrared
wavelengths. By combining 298 Spitzer spectra with 6 Infrared Space Observatory
spectra, we present kinematic information of the NLR for 81 z<=0.3 AGN. We used
the [NeV], [OIV], [NeIII], and [SIV] lines, whose fluxes correlate well with
each other, to probe gas photoionized by the AGN. We found that the widths of
the lines are, on average, increasing with the ionization potential of the
species that emit them. No correlation of the line width with the critical
density of the corresponding transition was found. The velocity dispersion of
the gas, sigma, is systematically higher than that of the stars, sigma_*, in
the AGN host galaxy, and it scales with the mass of the central black hole,
M_BH. Further correlations between the line widths and luminosities L, and
between L and M_BH, are suggestive of a three dimensional plane connecting
log(M_BH) to a linear combination of log(sigma) and log(L). Such a plane can be
understood within the context of gas motions that are driven by AGN feedback
mechanisms, or virialized gas motions with a power-law dependence of the NLR
radius on the AGN luminosity. The M_BH estimates obtained for 35 type 2 AGN
from this plane are consistent with those obtained from the M_BH-sigma_*
relation.Comment: ApJ, revised to match the print versio
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