The problems of production and sales of finished products

Effective activity of any enterprise is carried out proceeding from results of work - profit or a loss. For obtaining necessary profit level, it is necessary to organize correctly accounting, namely, to avoid such problems as: incorrect formation of accounting policies, doubtful information on prime cost of finished goods, low-quality work of accounting service at the enterprise, etc. It is necessary to find the reasons for this period of results of work, and with all confidence to approach the analysis of indicators, to open and realize reserves of improvement of indicators

Proof Loading to Assure Lumber Strength

The control of within-mill variations in the strength distribution of a given structural grade of lumber is of growing concern to the wood industry. Recent studies have proposed the use of on-line proof loading procedures to maintain quality through the elimination of weak pieces.An experiment was conducted on one thousand two hundred pieces of 2 x 4 No. 2 Dense KD Southern pine to determine the effect of both single and reverse bending proof loads on the strength of lumber tested in both bending and tension parallel-to-grain. The specimens were separated into six groups, each containing two hundred pieces. A pair of control groups, single proof load groups, and reverse proof load groups were tested. One group in each pair was failed in bending, the other was in tension. During the testing, no damage due to the proof loading was detected.Probabilistic analysis of the data indicates that the bending strength of the single proof loaded specimens could be reduced by 12% and still remain as reliable as the control. Reverse proof loaded specimens could tolerate a reduction of 33%. The tensile strength for each single proof loaded member could tolerate a reduction of 13%, while reverse proof loaded specimens could face a decrease of 18% and maintain a level of safety equal to the related control. When using a bending proof load to assure lumber strength, it is necessary to use a higher proof load to assure tensile strength than would be needed just to assure bending strength

SAWA experiment ? properties of mineral dust aerosol as seen by synergic lidar and sun-photometer measurements

International audienceWe propose a method of retrieving basic information on mineral dust aerosol particles from synergic sun-photometer and multi-wavelength lidar measurements as well as from the observations of lidar light depolarisation. We use this method in a case study of mineral dust episode in Central Europe. Lidar signals are inversed with a modified Klett-Fernald algorithm. Aerosol optical depth measured with the sun-photometer allows to reduce uncertainties in the inversion procedure through which we estimate vertical profile of aerosol extinction. Next we assume that aerosol particles may be represented by ensemble of randomly oriented, identical spheroids. Having calculated vertical profiles of aerosol extinction coefficients for lidar wavelengths, we compute the profiles of local Angstrom exponent. We use laser beam depolarisation together with the calculated Angstrom exponents to estimate the shapes (aspect ratios) and sizes of the spheroids. Numerical calculations are performed with the transition matrix (T-matrix) algorithm by M. Mishchenko. The proposed method was first used during SAWA measurement campaign in Warsaw, spring 2005, to characterise the particles of desert dust, drifting over Poland with a southern-eastern wind (13?14 April). Observations and T-matrix calculations show that mode radii of spheroids representative for desert aerosols' particles are in the range of 0.15?0.3 ?m, while their aspect ratios are lower than 0.7 or larger than 1.7

Progress towards lightning control using lasers

Lightning research needs on-demand lightning strikes, because of the random character of natural lightning. Lasers have been proposed as alternatives to the current technique using rocket-pulled wires, because they would expectedly provide more flexibility. However, high-energy, nanosecond lasers cannot provide long connected plasma channels. In contrast, we recently reported the triggering of electric events in thunderclouds using ultrashort laser pulses. Further improvements of the laser pulse sequence and experiment geometry are discussed

Continuous Regional Arterial Infusion with Fluorouracil and Octreotide Attenuates Severe Acute Pancreatitis in a Canine Model

Aim: To investigate the therapeutic effects of fluorouracil (5-Fu) and octreotide (Oct) continuous regional arterial infusion (CRAI,) alone or in combination, was administered in a canine model of severe acute pancreatitis (SAP). Materials and Methods: The animals were divided into five groups; group A (Sham), group B (SAP), group C (SAP and 5-Fu), group D (SAP and Oct), and group E (SAP and 5-Fu + Oct). Levels of amylase, alpha-tumor necrosis factor (TNF-alpha), blood urea nitrogen (BUN), creatinine, thromboxane B2 and 6-keto-prostaglandin F1 alpha were measured both before and after the induction of SAP. Pathologic examination of the pancreas and kidneys was performed after termination of the study. Results: Pathologic changes noted in the pancreas in SAP significantly improved following CRAI with either single or combined administration of 5-Fu and Oct, where combination therapy demonstrated the lowest injury score. All treatment groups had significantly lower levels of serum TNF-alpha and amylase activity (P<0.05), though only groups D and E had a lower BUN level as compared to group B. The plasma thromboxane B-2 level increased in SAP, but the ratio of thromboxane B-2/6-keto-prostaglandin F-1 alpha decreased in the treatment groups, with the combination therapy (group E) demonstrating the lowest ratio as compared to the other 3 experimental groups (P<0.05). Conclusions: The findings in the present study demonstrate an attenuation of SAP in a canine model following CRAI administration with 5-Fu or Oct, alone or in combination

CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo

Thus far the clinical benefits seen in breast cancer patients treated with drugs targeting the vascular endothelial growth factor (VEGF) pathway are only modest. Consequently, additional antiangiogenic approaches for treatment of breast cancer need to be investigated. Thrombospondin-2 (TSP-2) has been shown to inhibit tumor growth and angiogenesis with a greater potency than the related molecule TSP-1. The systemic effects of TSP-2 on tumor metastasis and the underlying molecular mechanisms of the antiangiogenic activity of TSP-2 have remained poorly understood. We generated a recombinant fusion protein consisting of the N-terminal region of TSP-2 and the IgG-Fc1 fragment (N-TSP2-Fc) and could demonstrate that the antiangiogenic activity of N-TSP2-Fc is dependent on the CD36 receptor. We found that N-TSP2-Fc inhibited VEGF-induced tube formation of human dermal microvascular endothelial cells (HDMEC) on matrigel in vitro and that concurrent incubation of anti-CD36 antibody with N-TSP2-Fc resulted in tube formation that was comparable to untreated control. N-TSP2-Fc potently induced apoptosis of HDMEC in vitro in a CD36-dependent manner. Moreover, we could demonstrate a CD36 receptor-mediated loss of mitochondrial membrane potential and activation of caspase-3 in HDMEC in vitro. Daily intraperitoneal injections of N-TSP2-Fc resulted in a significant inhibition of the growth of human MDA-MB-435 and MDA-MB-231 tumor cells grown in the mammary gland of immunodeficient nude mice and in reduced tumor vascularization. Finally, increased serum concentrations of N-TSP2-Fc significantly inhibited regional metastasis to lymph nodes and distant metastasis to lung as shown by quantitative real-time alu PCR. These results identify N-TSP2-Fc as a potent systemic inhibitor of tumor metastasis and provide strong evidence for an important role of the CD36 receptor in mediating the antiangiogenic activity of TSP-2

Arabidopsis CULLIN3 Genes Regulate Primary Root Growth and Patterning by Ethylene-Dependent and -Independent Mechanisms

CULLIN3 (CUL3) together with BTB-domain proteins form a class of Cullin-RING ubiquitin ligases (called CRL3s) that control the rapid and selective degradation of important regulatory proteins in all eukaryotes. Here, we report that in the model plant Arabidopsis thaliana, CUL3 regulates plant growth and development, not only during embryogenesis but also at post-embryonic stages. First, we show that CUL3 modulates the emission of ethylene, a gaseous plant hormone that is an important growth regulator. A CUL3 hypomorphic mutant accumulates ACS5, the rate-limiting enzyme in ethylene biosynthesis and as a consequence exhibits a constitutive ethylene response. Second, we provide evidence that CUL3 regulates primary root growth by a novel ethylene-dependant pathway. In particular, we show that CUL3 knockdown inhibits primary root growth by reducing root meristem size and cell number. This phenotype is suppressed by ethylene-insensitive or resistant mutations. Finally, we identify a function of CUL3 in distal root patterning, by a mechanism that is independent of ethylene. Thus, our work highlights that CUL3 is essential for the normal division and organisation of the root stem cell niche and columella root cap cells