Zinc/ammonium formate: a new facile system for the rapid and selective reduction of oximes to amines

Various oximes, both aldoximes and ketoximes, are selectively reduced to corresponding amines employing low cost zinc dust and ammonium formate despite presence of other functional groups such as halogens, -OH, -OCH3, -COOH, -CN, > C = C < and -CH3

Magnesium-catalyzed proficient reduction of oximes to amines using ammonium formate

Various aldoximes and ketoximes were selectively reduced to the corresponding amines by catalytic transfer hydrogenation employing low cost magnesium powder and ammonium formate at room temperature. Many other functionalities such as halogens, -OH, -OCH3, -COOH and -CH3 remained unaffected. The hydrogenation is fast, mild, clean, cost effective and high yielding

Zinc/Ammonium Formate: A New Facile System for the Rapid and Selective Reduction of Oximes to Amines.

Various oximes, both aldoximes and ketoximes, are selectively reduced to corresponding amines employing low cost zinc dust and ammonium formate despite presence of other functional groups such as halogens, -OH, -OCH3, -COOH, -CN, > C = C < and -CH3

New hydrogenation catalyst: An advantageous method for the removal of hydrogenolysable protecting groups in peptide synthesis

Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing ammonium formate and magnesium is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. The use of ammonium formate and magnesium makes this a rapid, low-cost alternative to palladium and reduces the work-up to a simple filtration and extraction operation

Clean and efficient hydrogenative cleavage of azo compounds using polymer-supported formate and zinc

Abstract Azo compounds, both symmetric and asymmetric, were chemoselectively reduced to the corresponding amine(s) using recyclable polymer‐supported formate as a hydrogen donor in the presence of zinc at room temperature