L'evolució de les retransmissions esportives a Espanya : tecnologia, posada en escena, públic i arquitectura

El present treball té com a objectiu conèixer la posada en escena de les retransmissions de futbol a Espanya així com veure quina ha estat la seva evolució al llarg dels anys. En aquest sentit, s'analitzaran els diferents elements visuals que formen part d'una realització televisiva de futbol i s'estudiarà quin ha estat i és el seu tractament en pantalla. S'examinarà també la influència que han tingut les innovacions tecnològiques.El presente trabajo tiene como objetivo conocer la puesta en escena de las retransmisiones de fútbol en España, así como ver cual ha sido su evolución a lo largo de los años. En este sentido, se analizarán los diferentes elementos visuales que forman parte de una realización televisiva de fútbol y se estudiará cual ha estado y es su tratamiento en pantalla. Se examinará también la influencia que han tenido las innovaciones tecnológicas.The objective of this work is to know the staging of football retransmissions in Spain, as well as to see what has been its evolution over the years. In this sense, the different visual elements that are part of a televised televised soccer performance will be analyzed and their treatment will be studied on the screen. The influence of technological innovations will also be examined

Addictive and wonderful : the experience of reading the Harry Potter series

Aquest document està relacionat amb: Charming and bewitching : considering the Harry Potter serie

Tècniques i sistemes de la construcció industralitzada: treballs de l'assignatura, primavera 2014: Escola bressol Els Pins a Santa Perpètua de la Moguda

2014/201

Tècniques i sistemes de la construcció industralitzada: treballs de l'assignatura, primavera 2014: Escola bressol Els Pins a Santa Perpètua de la Moguda

2014/201

Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension

Background & Aims: Portal hypertension (PH) is a frequent and severe clinical syndrome associated with chronic liver disease. Considering the mechanobiological effects of hydrostatic pressure and shear stress on endothelial cells, we hypothesised that PH might influence the phenotype of liver sinusoidal endothelial cells (LSECs) during disease progression. The aim of this study was to investigate the effects of increased hydrodynamic pressure on LSECs and to identify endothelial-derived biomarkers of PH. Methods: Primary LSECs were cultured under normal or increased hydrodynamic pressure within a pathophysiological range (1 vs. 12 mmHg) using a microfluidic liver-on-a-chip device. RNA sequencing was used to identify pressure-sensitive genes, which were validated in liver biopsies from two independent cohorts of patients with chronic liver disease with PH (n = 73) and participants without PH (n = 23). Biomarker discovery was performed in two additional independent cohorts of 104 patients with PH and 18 patients without PH. Results: Transcriptomic analysis revealed marked deleterious effect of pathological pressure in LSECs and identified chromobox 7 (CBX7) as a key transcription factor diminished by pressure. Hepatic CBX7 downregulation was validated in patients with PH and significantly correlated with hepatic venous pressure gradient. MicroRNA 181a-5p was identified as pressure-induced upstream regulator of CBX7. Two downstream targets inhibited by CBX7, namely, E-cadherin (ECAD) and serine protease inhibitor Kazal-type 1 (SPINK1), were found increased in the bloodstream of patients with PH and were highly predictive of PH and clinically significant PH. Conclusions: We characterise the detrimental effects of increased hydrodynamic pressure on the sinusoidal endothelium, identify CBX7 as a pressure-sensitive transcription factor, and propose the combination of two of its reported products as biomarkers of PH. Impact and Implications: Increased pressure in the portal venous system that typically occurs during chronic liver disease (called portal hypertension) is one of the main drivers of related clinical complications, which are linked to a higher risk of death. In this study, we found that pathological pressure has a harmful effect on liver sinusoidal endothelial cells and identified CBX7 as a key protein involved in this process. CBX7 regulates the expression of E-cadherin and SPINK1, and consequently, measuring these proteins in the blood of patients with chronic liver disease allows the prediction of portal hypertension and clinically significant portal hypertension

Tècniques i sistemes de construcció industrialitzada: Recull d’exercicis curs 2013-2014

2014/201

Tècniques i sistemes de construcció industrialitzada: Recull d’exercicis curs 2013-2014

2014/201