Museums, Leadership, and Transfer: An Inquiry into Organizational Supports for Learning Leadership

Given the rapid changes that 21st century museums must manage, flexible thinking about leadership forms and purposes is needed. Today\u27s complex leadership landscape necessitates that staff engage in enacting leadership with positional leaders. Limited empirical literature exists that describes how the next generation of museum leaders is being nurtured and developed. The purpose of this study was to: describe museum professionals\u27 perceptions of leadership practices; investigate museums as sites of organizational and leadership learning; and consider the experiences of museum professionals who have participated in leader development programs. The study involved an on-line survey with 310 professionals working in U.S. museums and follow-up interviews with a subset of 13 survey participants. Bolman and Deal\u27s (1990) Leadership Orientations Inventory (BDLO) was used to assess museum leadership practices; Marsick and Watkins (1999) 21-item version Dimensions of a Learning Organization Questionnaire (DLOQ-A) was used to assess supports for learning in the museum. Findings based on bivariate correlation and multiple regression analysis show a significant relationship between ratings for leadership effectiveness at the department and organization levels and scores on the BDLO and the DLOQ-A. While leadership effectiveness at both levels tended to be positive, over 60% of middle and non-managers did not perceive their museum’s leadership as mastering any of the BDLO Leadership Orientations Inventory frames. Statistically significant differences in the perception of museums as learning organizations were found with decreasing support from senior managers to middle managers to non-managers. With regard to learning leadership, findings indicate that the DLOQ-A Strategic Leadership for Learning dimension, Organization Support, and Peer Support are important for facilitating continued learning and application of new knowledge and skills derived from leader development programs. Finally, most leader development program participants indicated that they were immediately able to apply some skills learned; however sustaining incorporation of new knowledge was difficult. Implications for museum professionals, leader development program providers, museum studies programs, leadership and change, and future research are discussed. A digital introduction accompanies this dissertation. The electronic version of this dissertation is at OhioLink ETD Center, www.ohiolink.edu/etd

Museums, Leadership, and Transfer: An Inquiry into Organizational Supports for Learning Leadership

Given the rapid changes that 21st century museums must manage, flexible thinking about leadership forms and purposes is needed. Today\u27s complex leadership landscape necessitates that staff engage in enacting leadership with positional leaders. Limited empirical literature exists that describes how the next generation of museum leaders is being nurtured and developed. The purpose of this study was to: describe museum professionals\u27 perceptions of leadership practices; investigate museums as sites of organizational and leadership learning; and consider the experiences of museum professionals who have participated in leader development programs. The study involved an on-line survey with 310 professionals working in U.S. museums and follow-up interviews with a subset of 13 survey participants. Bolman and Deal\u27s (1990) Leadership Orientations Inventory (BDLO) was used to assess museum leadership practices; Marsick and Watkins (1999) 21-item version Dimensions of a Learning Organization Questionnaire (DLOQ-A) was used to assess supports for learning in the museum. Findings based on bivariate correlation and multiple regression analysis show a significant relationship between ratings for leadership effectiveness at the department and organization levels and scores on the BDLO and the DLOQ-A. While leadership effectiveness at both levels tended to be positive, over 60% of middle and non-managers did not perceive their museum’s leadership as mastering any of the BDLO Leadership Orientations Inventory frames. Statistically significant differences in the perception of museums as learning organizations were found with decreasing support from senior managers to middle managers to non-managers. With regard to learning leadership, findings indicate that the DLOQ-A Strategic Leadership for Learning dimension, Organization Support, and Peer Support are important for facilitating continued learning and application of new knowledge and skills derived from leader development programs. Finally, most leader development program participants indicated that they were immediately able to apply some skills learned; however sustaining incorporation of new knowledge was difficult. Implications for museum professionals, leader development program providers, museum studies programs, leadership and change, and future research are discussed. A digital introduction accompanies this dissertation. The electronic version of this dissertation is at OhioLink ETD Center, www.ohiolink.edu/etd

Rapid detection of snakes modulates spatial orienting in infancy

Recent evidence for an evolved fear module in the brain comes from studies showing that adults, children and infants detect evolutionarily threatening stimuli such as snakes faster than non-threatening ones. A decisive argument for a threat detection system efficient early in life would come from data showing, in young infants, a functional threat-detection mechanism in terms of “what” and “where” visual pathways. The present study used a variant of Posner’s cuing paradigm, adapted to 7–11-month-olds. On each trial, a threat-irrelevant or a threat-relevant cue was presented (a flower or a snake, i.e., “what”). We measured how fast infants detected these cues and the extent to which they further influenced the spatial allocation of attention (“where”). In line with previous findings, we observed that infants oriented faster towards snake than flower cues. Importantly, a facilitation effect was found at the cued location for flowers but not for snakes, suggesting that these latter cues elicit a broadening of attention and arguing in favour of sophisticated “what–where” connections. These results strongly support the claim that humans have an early propensity to detect evolutionarily threat-relevant stimuli

Molecular determinants and intracellular targets of taurine signalling in pancreatic islet β‐cells

AbstractAimDespite its abundance in pancreatic islets of Langerhans and proven antihyperglycemic effects, the impact of the essential amino acid, taurine, on islet β‐cell biology has not yet received due consideration, which prompted the current studies exploring the molecular selectivity of taurine import into β‐cells and its acute and chronic intracellular interactions.MethodsThe molecular aspects of taurine transport were probed by exposing the clonal pancreatic BRIN BD11 β‐cells and primary mouse and human islets to a range of the homologs of the amino acid (assayed at 2–20 mM), using the hormone release and imaging of intracellular signals as surrogate read‐outs. Known secretagogues were employed to profile the interaction of taurine with acute and chronic intracellular signals.ResultsTaurine transporter TauT was expressed in the islet β‐cells, with the transport of taurine and homologs having a weak sulfonate specificity but significant sensitivity to the molecular weight of the transporter. Taurine, hypotaurine, homotaurine, and β‐alanine enhanced insulin secretion in a glucose‐dependent manner, an action potentiated by cytosolic Ca2+ and cAMP. Acute and chronic β‐cell insulinotropic effects of taurine were highly sensitive to co‐agonism with GLP‐1, forskolin, tolbutamide, and membrane depolarization, with an unanticipated indifference to the activation of PKC and CCK8 receptors. Pre‐culturing with GLP‐1 or KATP channel inhibitors sensitized or, respectively, desensitized β‐cells to the acute taurine stimulus.ConclusionTogether, these data demonstrate the pathways whereby taurine exhibits a range of beneficial effects on insulin secretion and β‐cell function, consistent with the antidiabetic potential of its dietary low‐dose supplementation

Diagnostic Performance of Clinicopathological Analytes in Otostrongylus circumlitis-Infected Rehabilitating Juvenile Northern Elephant Seals (Mirounga angustirostris)

The nematode lungworm, Otostrongylus circumlitis (OC), is a significant cause of northern elephant seal (NES; Mirounga angustirostris) mortality at The Marine Mammal Center (TMMC, Sausalito, CA). The current lack of specific antemortem diagnostic tests for pre-patent OC infection in NES makes diagnosis, proper treatment, and assessment of efficacy of medications challenging. Severe inflammation and disseminated intravascular coagulation (DIC) develop rapidly and are difficult to treat once clinical signs develop. Certain blood inflammatory and hemostasis biomarkers for early diagnosis have recently been investigated. The objective of this study was to investigate the diagnostic performance of complete blood count, serum chemistry, acute phase proteins, protein electrophoresis, and coagulation parameters for diagnosis of OC clinical infection in NES. Samples from NES with OC infection confirmed by gross pathology with blood collected antemortem during clinical disease (n = 9) and NES initially admitted for malnutrition and sampled shortly before release after successful rehabilitation (n = 20) were included in the study. Using Receiver operator characteristic (ROC) curve analysis, the diagnostic performances (area under the curve [AUC]) of albumin (0.994), albumin:globulin ratio (0.983), serum amyloid A (0.972), activated partial thromboplastin time (0.936), total bilirubin (0.975), and gamma-glutamyl transferase (0.939) were high (AUC > 0.9). These results confirm systemic inflammation and DIC, and support previously reported clinical and gross pathological findings in NES infected with OC. In addition to AUC values, this study produced cut-off points, sensitivity, specificity, confidence intervals, and predictive values for analytes with high diagnostic performance. This data will be useful in the diagnosis and clinical management of OC-infected NES and will aid in assessment of treatment efficacy

The Relationship Between Fractures and DXA Measures of BMD in the Distal Femur of Children and Adolescents With Cerebral Palsy or Muscular Dystrophy

Children with limited or no ability to ambulate frequently sustain fragility fractures. Joint contractures, scoliosis, hip dysplasia, and metallic implants often prevent reliable measures of bone mineral density (BMD) in the proximal femur and lumbar spine, where BMD is commonly measured. Further, the relevance of lumbar spine BMD to fracture risk in this population is questionable. In an effort to obtain bone density measures that are both technically feasible and clinically relevant, a technique was developed involving dual-energy X-ray absorptiometry (DXA) measures of the distal femur projected in the lateral plane. The purpose of this study is to test the hypothesis that these new measures of BMD correlate with fractures in children with limited or no ability to ambulate. The relationship between distal femur BMD Z-scores and fracture history was assessed in a cross-sectional study of 619 children aged 6 to 18 years with muscular dystrophy or moderate to severe cerebral palsy compiled from eight centers. There was a strong correlation between fracture history and BMD Z-scores in the distal femur; 35% to 42% of those with BMD Z-scores less than −5 had fractured compared with 13% to 15% of those with BMD Z-scores greater than −1. Risk ratios were 1.06 to 1.15 (95% confidence interval 1.04–1.22), meaning a 6% to 15% increased risk of fracture with each 1.0 decrease in BMD Z-score. In clinical practice, DXA measure of BMD in the distal femur is the technique of choice for the assessment of children with impaired mobility. © 2010 American Society for Bone and Mineral Researc

Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease.

OBJECTIVES: Visuospatial processing deficits have been reported in Huntington's disease (HD). To date, no study has examined associations between visuospatial cognition and posterior brain findings in HD. METHODS: We compared 119 premanifest (55> and 64<10.8 years to expected disease onset) and 104 early symptomatic (59 stage-1 and 45 stage-2) gene carriers, with 110 controls on visual search and mental rotation performance at baseline and 12 months. In the disease groups, we also examined associations between task performance and disease severity, functional capacity and structural brain measures. RESULTS: Cross-sectionally, there were strong differences between all disease groups and controls on visual search, and between diagnosed groups and controls on mental rotation accuracy. Only the premanifest participants close to onset took longer than controls to respond correctly to mental rotation. Visual search negatively correlated with disease burden and motor symptoms in diagnosed individuals, and positively correlated with functional capacity. Mental rotation ("same") was negatively correlated with motor symptoms in stage-2 individuals, and positively correlated with functional capacity. Visual search and mental rotation were associated with parieto-occipital (pre-/cuneus, calcarine, lingual) and temporal (posterior fusiform) volume and cortical thickness. Longitudinally, visual search deteriorated over 12 months in stage-2 individuals, with no evidence of declines in mental rotation. CONCLUSIONS: Our findings provide evidence linking early visuospatial deficits to functioning and posterior cortical dysfunction in HD. The findings are important since large research efforts have focused on fronto-striatal mediated cognitive changes, with little attention given to aspects of cognition outside of these areas. (JINS, 2016, 22, 595-608)

Qualitative study of system-level factors related to genomic implementation

PURPOSE: Research on genomic medicine integration has focused on applications at the individual level, with less attention paid to implementation within clinical settings. Therefore, we conducted a qualitative study using the Consolidated Framework for Implementation Research (CFIR) to identify system-level factors that played a role in implementation of genomic medicine within Implementing GeNomics In PracTicE (IGNITE) Network projects. METHODS: Up to four study personnel, including principal investigators and study coordinators from each of six IGNITE projects, were interviewed using a semistructured interview guide that asked interviewees to describe study site(s), progress at each site, and factors facilitating or impeding project implementation. Interviews were coded following CFIR inner-setting constructs. RESULTS: Key barriers included (1) limitations in integrating genomic data and clinical decision support tools into electronic health records, (2) physician reluctance toward genomic research participation and clinical implementation due to a limited evidence base, (3) inadequate reimbursement for genomic medicine, (4) communication among and between investigators and clinicians, and (5) lack of clinical and leadership engagement. CONCLUSION: Implementation of genomic medicine is hindered by several system-level barriers to both research and practice. Addressing these barriers may serve as important facilitators for studying and implementing genomics in practice