An application of design knowledge captured from multiple sources

The Hubble Space Telescope Operational Readiness Expert Safemode Investigation System (HSTORESIS) is a reusable knowledge base shell used to demonstrate the integration and application of design knowledge captured from multiple technical domains. The design of HSTORESIS is based on a partitioning of knowledge to maximize the potential for reuse of certain types of knowledge

Tracking and Testing Of US and Canadian Cattle Herds for BSE: A Risk Management Dilemma

Livestock Production/Industries,

Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution

Endothelial lipase (gene: LIPG; enzyme: EL) is one of three members of the triglyceride lipase family that contributes to lipoprotein degradation within the circulation system and plays a major role in HDL metabolism in the body. In this study, in silico methods were used to predict the amino acid sequences, secondary and tertiary structures, and gene locations for LIPG genes and encoded proteins using data from several vertebrate genome projects. LIPG is located on human chromosome 18 and is distinct from other human 'neutral lipase' genes, hepatic lipase (gene: LIPC; enzyme: HL) and lipoprotein lipase (gene: LPL; enzyme: LPL) examined. Vertebrate LIPG genes usually contained 10 coding exons located on the positive strand for most primates, as well as for horse, bovine, opossum, platypus and frog genomes. The rat LIPG gene however contained only 9 coding exons apparently due to the presence of a 'stop' codon' within exon 9. Vertebrate EL protein subunits shared 58-97% sequence identity as compared with 38-45% sequence identities with human HL and LPL. Four previously reported human EL N-glycosylation sites were predominantly conserved among the 10 potential N-glycosylation sites observed for the vertebrate EL sequences examined. Sequence alignments and identities for key EL amino acid residues were observed as well as conservation of predicted secondary and tertiary structures with those previously reported for horse pancreatic lipase (PL) (Bourne et al. 1994). Several potential sites for regulating LIPG gene expression were observed including CpG islands near the LIPG gene promoter and a predicted microRNA binding site near the 3'-untranslated region. Promoter regions containing functional polymorphisms that regulate HDL cholesterol in baboons were conserved among primates but not retained between primates and rodents. Phylogenetic analyses examined the relationships and potential evolutionary origins of the vertebrate LIPG gene subfamily with other neutral triglyceride lipase gene families, LIPC and LPL. It is apparent that the triglyceride lipase ancestral gene for the vertebrate LIPG gene predated the appearance of fish during vertebrate evolution[500 million years ago.Full Tex

On the road again: Corridor effects on nesting passerines in Missouri forests [abstract]

Abstract only availableRoads and other linear corridors may have profound ecological consequences. Direct mortality of adult birds by vehicle collisions is well documented, but increased nest predation along road corridors has not been shown in passerines. I tested the hypothesis that nests proximal to unimproved roads (<10 m) suffer greater nest predation than those further from roads (11+ m) due to a predator-corridor effect. Nests from four sites in Missouri were found, monitored, and filmed during the spring and summer of 2007. Roadside shrub-nesting passerines did not experience significantly lower nest success than those nesting far from roads. Acadian Flycatchers experienced significantly higher nest success than did birds of the shrub-nesting guild as a whole. Initial predator identifications are presented

Downward shortwave surface irradiance from 17 sites for the FIRE/SRB Wisconsin experiment

A field experiment was conducted in Wisconsin during Oct. to Nov. 1986 for purposes of both intensive cirrus cloud measurments and SRB algorithm validation activities. The cirrus cloud measurements were part of the FIRE. Tables are presented which show data from 17 sites in the First ISCCP (International Satellite Cloud Climatology Project) Regional Experiment/Surface Radiation Budget (FIRE/SRB) Wisconsin experiment region. A discussion of intercomparison results and calibration inconsistencies is also included

On the He II Emission In Eta Carinae and the Origin of Its Spectroscopic Events

We describe and analyze Hubble Space Telescope (HST) observations of transient emission near 4680 {\AA} in Eta Car, reported earlier by Steiner & Damineli (2004). If, as seems probable, this is He II $\lambda$4687, then it is a unique clue to Eta Car's 5.5-year cycle. According to our analysis, several aspects of this feature support a mass-ejection model of the observed spectroscopic events, and not an eclipse model. The He II emission appeared in early 2003, grew to a brief maximum during the 2003.5 spectroscopic event, and then abruptly disappeared. It did not appear in any other HST spectra before or after the event. The peak brightness was larger than previously reported, and is difficult to explain even if one allows for an uncertainty factor of order 3. The stellar wind must provide a temporary larger-than-normal energy supply, and we describe a special form of radiative amplification that may also be needed. These characteristics are consistent with a class of mass-ejection or wind-disturbance scenarios, which have implications for the physical structure and stability of Eta Car.Comment: 47 pages (including all appendices, tabs, & figs), 9 figures, 3 tables; submitted to Astrophysical Journal (2005 March 29), accepted for publication in Ap

Experimental Evaluation of Psychophysical Distortion Metrics for JPEG-Encoded Images

Two experiments for evaluating psychophysical distortion metrics for JPEG-encoded images are described. The first is a threshold experiment, in which subjects determined the bit rate or level of distortion at which distortion was just noticeable. The second is a suprathreshold experiment in which subjects ranked image blocks according to perceived distortion. The results of these experiments were used to determine the predictive value of a number of computer image distortion metrics. It was found that mean-square-error is not a good predictor of distortion thresholds or suprathreshold perceived distortion. Some simple pointwise measures were in good agreement with psychophysical data; other more computationally intensive metrics involving spatial properties of the human visual system gave mixed results. It was determined that mean intensity, which is not accounted for in the JPEG algorithm, plays a significant role in perceived distortion

Tracking Cyber Adversaries with Adaptive Indicators of Compromise

A forensics investigation after a breach often uncovers network and host indicators of compromise (IOCs) that can be deployed to sensors to allow early detection of the adversary in the future. Over time, the adversary will change tactics, techniques, and procedures (TTPs), which will also change the data generated. If the IOCs are not kept up-to-date with the adversary's new TTPs, the adversary will no longer be detected once all of the IOCs become invalid. Tracking the Known (TTK) is the problem of keeping IOCs, in this case regular expressions (regexes), up-to-date with a dynamic adversary. Our framework solves the TTK problem in an automated, cyclic fashion to bracket a previously discovered adversary. This tracking is accomplished through a data-driven approach of self-adapting a given model based on its own detection capabilities. In our initial experiments, we found that the true positive rate (TPR) of the adaptive solution degrades much less significantly over time than the naive solution, suggesting that self-updating the model allows the continued detection of positives (i.e., adversaries). The cost for this performance is in the false positive rate (FPR), which increases over time for the adaptive solution, but remains constant for the naive solution. However, the difference in overall detection performance, as measured by the area under the curve (AUC), between the two methods is negligible. This result suggests that self-updating the model over time should be done in practice to continue to detect known, evolving adversaries.Comment: This was presented at the 4th Annual Conf. on Computational Science & Computational Intelligence (CSCI'17) held Dec 14-16, 2017 in Las Vegas, Nevada, US