14 research outputs found
Assessment of the state-of-the-art trueness and precision of serum total-calcium and glucose measurements in Finnish laboratories - the QSL-Finland study.
Functional genetic variation of the cannabinoid receptor 1 and cannabis use interact on prefrontal connectivity and related working memory behavior
Cannabinoid signaling is involved in different brain functions and it is mediated by the cannabinoid receptor 1 (CNR1), which is encoded
by the CNR1 gene. Previous evidence suggests an association between cognition and cannabis use. The logical interaction between
genetically determined cannabinoid signaling and cannabis use has not been determined. Therefore, we investigated whether CNR1
variation predicts CNR1 prefrontal mRNA expression in postmortem prefrontal human tissue. Then, we studied whether functional
variation in CNR1 and cannabis exposure interact in modulating prefrontal function and related behavior during working memory
processing. Thus, 208 healthy subjects (113 males) were genotyped for the relevant functional SNP and were evaluated for cannabis use
by the Cannabis Experience Questionnaire. All individuals performed the 2-back working memory task during functional magnetic
resonance imaging. CNR1 rs1406977 was associated with prefrontal mRNA and individuals carrying a G allele had reduced CNR1
prefrontal mRNA levels compared with AA subjects. Moreover, functional connectivity MRI demonstrated that G carriers who were also
cannabis users had greater functional connectivity in the left ventrolateral prefrontal cortex and reduced working memory behavioral
accuracy during the 2-back task compared with the other groups. Overall, our results indicate that the deleterious effects of cannabis use
are more evident on a specific genetic background related to its receptor expression