1,172 research outputs found
Protection Against Cardiac Injury by Small Ca\u3csup\u3e2 +\u3c/sup\u3e-Sensitive K\u3csup\u3e+\u3c/sup\u3e Channels Identified in Guinea Pig Cardiac Inner Mitochondrial Membrane
We tested if small conductance, Ca2 +‐sensitive K+ channels (SKCa) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial (m) bioenergetics, if O2‐derived free radicals are required to initiate protection via SKCa channels, and, importantly, if SKCa channels are present in cardiac cell inner mitochondrial membrane (IMM). NADH and FAD, superoxide (O2−), and m[Ca2 +] were measured in guinea pig isolated hearts by fluorescence spectrophotometry. SKCa and IKCa channel opener DCEBIO (DCEB) was given for 10 min and ended 20 min before IR. Either TBAP, a dismutator of O2−, NS8593, an antagonist of SKCa isoforms, or other KCa and KATP channel antagonists, were given before DCEB and before ischemia. DCEB treatment resulted in a 2-fold increase in LV pressure on reperfusion and a 2.5 fold decrease in infarct size vs. non-treated hearts associated with reduced O2− and m[Ca2 +], and more normalized NADH and FAD during IR. Only NS8593 and TBAP antagonized protection by DCEB. Localization of SKCa channels to mitochondria and IMM was evidenced by a) identification of purified mSKCa protein by Western blotting, immuno-histochemical staining, confocal microscopy, and immuno-gold electron microscopy, b) 2-D gel electrophoresis and mass spectroscopy of IMM protein, c) [Ca2 +]‐dependence of mSKCa channels in planar lipid bilayers, and d) matrix K+ influx induced by DCEB and blocked by SKCa antagonist UCL1684. This study shows that 1) SKCa channels are located and functional in IMM, 2) mSKCa channel opening by DCEB leads to protection that is O2−dependent, and 3) protection by DCEB is evident beginning during ischemia
Cultural orientation of self-bias in perceptual matching
This work was supported by grants from the Economic and Social Research Council (ES/K013424/1), the National Natural Science Foundation of China (31371017), and the Research Grants Council of Hong Kong (HKU758412H)Peer reviewedPublisher PD
Finite Grand Unified Theories and the Quark Mixing Matrix
In N = 1 super Yang-Mills theories, under certain conditions satisfied by the
spectrum and the Yukawa couplings, the beta functions will vanish to all orders
in perturbation theory. We address the generation of realistic quark mixing
angles and masses in such finite Grand Unified Theories. Working in the context
of finite SUSY SU(5), we present several examples with realistic quark mixing
matrices. Non-Abelian discrete symmetries are found to be important in
satisfying the conditions for finiteness. Our realistic examples are based on
permutation symmetries and the tetrahedral symmetry . These examples
enable us to address questions such as the decay rate of the proton in finite
GUTs.Comment: 16 pages, LaTeX, typos correcte
Pair production of neutralinos via gluon-gluon collisions
The production of a neutralino pair via gluon-gluon fusion is studied in the
minimal supersymmetric model(MSSM) at proton-proton colliders. The numerical
analysis of their production rates are carried out in the mSUGRA scenario. The
results show that this cross section may reach about 80 femto barn for
pair production and 23 femto barn
for pair production with suitable
input parameters at the future LHC collider. It shows that this loop mediated
process can be competitive with the quark-antiquark annihilation process at the
LHC.Comment: LaTex file, l4 pages, 5 EPS figure
Anomalous behavior in an effective model of graphene with Coulomb interactions
We analyze by exact Renormalization Group (RG) methods the infrared
properties of an effective model of graphene, in which two-dimensional massless
Dirac fermions propagating with a velocity smaller than the speed of light
interact with a three-dimensional quantum electromagnetic field. The fermionic
correlation functions are written as series in the running coupling constants,
with finite coefficients that admit explicit bounds at all orders. The
implementation of Ward Identities in the RG scheme implies that the effective
charges tend to a line of fixed points. At small momenta, the quasi-particle
weight tends to zero and the effective Fermi velocity tends to a finite value.
These limits are approached with a power law behavior characterized by
non-universal critical exponents.Comment: 42 pages, 7 figures; minor corrections, one appendix added (Appendix
A). To appear in Ann. Henri Poincar
Tight bounds on the competitive ratio on accomodating sequences for the seat reservation problem
The unit price seat reservation problem is investigated. The seat reservation problem is the problem of assigning seat numbers on-line to requests for reservations in a train traveling through stations. We are considering the version where all tickets have the same price and where requests are treated fairly, i.e., a request which can be fulfilled must be granted. For fair deterministic algorithms, we provide an asymptotically matching upper bound to the existing lower bound which states that all fair algorithms for this problem are frac{1{2-competitive on accommodating sequences, when there are at least three seats. Additionally, we give an asymptotic upper bound of frac{7{9 for fair randomized algorithms against oblivious adversaries. We also examine concrete on-line algorithms, First-Fit and Random, for the special case of two seats. Tight analyses of their performance are given
Donor Centers and Absorption Spectra in Quantum Dots
We have studied the electronic properties and optical absorption spectra of
three different cases of donor centers, D^{0}, D^{-} and D^{2-}, which are
subjected to a perpendicular magnetic field, using the exact diagonalization
method. The energies of the lowest lying states are obtained as function of the
applied magnetic field strength B and the distance zeta between the positive
ion and the confinement xy-plane. Our calculations indicate that the positive
ion induces transitions in the ground-state, which can be observed clearly in
the absorption spectra, but as zeta goes to 0 the strength of the applied
magnetic field needed for a transition to occur tends to infinity.Comment: 5 pages, 4 figures, REVTeX 4, gzipped tar fil
A study on simulation analysis for laser-welded I-core sandwich plate with different material properties and T-joint weld characteristic
Stiffness and strength of sandwich plate vary depending on similar (SI) or dissimilar (DSI) material element (faceplate or core) and laser weld geometry. The issues of I-core sandwich plate characteristics are essential to attain practical sandwich plate application. Hence, research on different material properties and T-joint weld characteristics of I-core sandwich steel plate presents a positive understanding of various character factors that affect sandwich plate bending performance. In this paper, the I-core sandwich steel plate characteristic was investigated using finite element analysis (FEA). The 3-point bending with a fine meshing, interaction of elements, and load applied was kept constant. The partition size at the laser weld geometry is smaller, and the partition size continuously grows when further away from the weld geometry. The result shows that a combination of weak and strong material on either element will reduce I-core sandwich's stiffness and strength unless strong material is assigned at the faceplate and core. Moreover, there is a significant change when rootgap is present. This influencing the centric and eccentric of the weld. The weld width produces a perfect bending as wholesome T-joint, yet to achieve such traits is impossible in reality but possible when the weld length is closer to the length of the core. The exploration of these characteristics in response to I-core sandwich steel plate holds a good response in engaging for the multiple variables that affect the plate's stiffness and strength
Pairing symmetry of superconducting graphene
The possibility of intrinsic superconductivity in alkali-coated graphene
monolayers has been recently suggested theoretically. Here, we derive the
possible pairing symmetries of a carbon honeycomb lattice and discuss their
phase diagram. We also evaluate the superconducting local density of states
(LDOS) around an isolated impurity. This is directly related to scanning
tunneling microscopy experiments, and may evidence the occurrence of
unconventional superconductivity in graphene.Comment: Eur. Phys. J. B, to appea
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