3,221 research outputs found
Polarizable Embedding Based on Multiconfigurational Methods: Current Developments and the Road Ahead
Metal/fiber laminate and fabrication using a porous metal/fiber preform
A metal/fiber laminate has a plurality of adjacent layers. Each layer is porous and includes an arrangement of fibers. At least one of the layers has its fibers coated with a metal. A polymer matrix permeates each such arrangement
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
Copyright © 2015 Lina M. Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase in O2 (∙-) production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue. Therefore, because of its dual actions, we studied the effect of quercetin in vivo to analyze heart mitochondrial function and erythropoiesis. Mice were injected with 50 mg/kg of quercetin for 15 days. Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice. Along with an impaired antioxidant capacity in plasma, quercetin-treated mice showed a significant delay on erythropoiesis progression. Heart mitochondrial function was also impaired displaying more protein oxidation and less activity for IV, respectively, than no-treated mice. In addition, a significant reduction in the protein expression levels of Mitofusin 2 and Voltage-Dependent Anion Carrier was observed. All these results suggest that quercetin affects erythropoiesis and mitochondrial function and then its potential use as a dietary supplement should be reexamined.Peer reviewe
Statistics of Cycles: How Loopy is your Network?
We study the distribution of cycles of length h in large networks (of size
N>>1) and find it to be an excellent ergodic estimator, even in the extreme
inhomogeneous case of scale-free networks. The distribution is sharply peaked
around a characteristic cycle length, h* ~ N^a. Our results suggest that h* and
the exponent a might usefully characterize broad families of networks. In
addition to an exact counting of cycles in hierarchical nets, we present a
Monte-Carlo sampling algorithm for approximately locating h* and reliably
determining a. Our empirical results indicate that for small random scale-free
nets of degree exponent g, a=1/(g-1), and a grows as the nets become larger.Comment: Further work presented and conclusions revised, following referee
report
Fiber Metal Laminates Made by the VARTM Process
Fiber metal laminates (FMLs) are multi-component materials utilizing metals, fibers and matrix resins. Tailoring their properties is readily achievable by varying one or more of these components. Established FMLs like GLARE utilize aluminum foils, glass fibers and epoxy matrices and are manufactured using an autoclave. Two new processes for manufacturing FMLs using vacuum assisted resin transfer molding (VARTM) have been developed at the NASA Langley Research Center (LaRC). A description of these processes and the resulting FMLs are presented
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