Protocol for measuring myocardial blood flow by PET/CT in cats

Purpose: The aim of this study was to establish a protocol for measuring myocardial blood flow (MBF) by PET/CT in healthy cats. The rationale was its future use in Maine Coon cats with hypertrophic cardiomyopathy (HCM) as a model for human HCM. Methods: MBF was measured in nine anaesthetized healthy cats using a PET/CT scanner and 13NH3 at rest and during adenosine infusion. Each cat was randomly assigned to receive vasodilator stress with two or three adenosine infusions at the following rates (μg/kg per minute): 140 (Ado1, standard rate for humans), 280 (Ado2, twice the human standard rate), 560 (Ado4), 840 (Ado6) and 1,120 (Ado8). Results: The median MBF at rest was 1.26ml/min per g (n = 9; range 0.88-1.72ml/min per g). There was no significant difference at Ado1 (n = 3; median 1.35, range 0.93-1.55ml/min per g; ns) but MBF was significantly greater at Ado2 (n = 6; 2.16, range 1.35-2.68ml/min per g; p < 0.05) and Ado4 (n = 6; 2.11, 1.92-2.45ml/min per g; p < 0.05). Large ranges of MBF values at Ado6 (n = 4; 2.53, 2.32-5.63ml/min per g; ns) and Ado8 (n = 3; 2.21, 1.92-5.70ml/min per g; ns) were noted. Observed adverse effects, including hypotension, AV-block and ventricular premature contractions, were all mild, of short duration and immediately reversed after cessation of the adenosine infusion. Conclusion: MBF can be safely measured in cats using PET. An intravenous adenosine infusion at a rate of 280μg/kg per minute seems most appropriate to induce maximal hyperaemic MBF response in healthy cats. Higher adenosine rates appear less suitable as they are associated with a large heterogeneity in flow increase and rate pressure product, most probably due to the large variability in haemodynamic and heart rate respons

A systematic evaluation of physical activity and diet policies in Scotland: Results from the 2021 Active Healthy Kids Report Card

Background Policymaking regarding physical activity (PA) and diet plays an important role in childhood health promotion. This study provides a detailed examination of Scottish government and policy for child and adolescent PA and diet and discusses strengths and areas for improvement. Methods Scottish policy documents (n = 18 [PA]; n = 10 [diet])—published in 2011–20—were reviewed for grading using an adapted version of the Health-Enhancing Physical Activity Policy Audit Tool Version 2. Results There is clear evidence of leadership and commitment to improving PA and diet and tackling obesity in children and adolescents. The allocation of funds and resources for policy implementation has increased substantially over the past decade. Progress through early key stages of public policymaking—policy agenda and formation—has improved. However, there is limited information on later key stages, including policy monitoring and evaluation. Conclusions Childhood PA and diet are a clear priority in Scotland, and PA and diet policies clearly support the desire to achieve other goals, including reducing inequalities and increasing active travel in Scotland. Nonetheless, future policies should be further strengthened through clear(er) plans of implementation, and monitoring and evaluation to support their societal impact

Regional sociocultural differences as important correlate of physical activity and sedentary behaviour in Swiss preschool children

Regional differences in physical activity in school-aged children and adults even within one country with the same political and health care system have been observed and could not be explained by sociodemographic or individual variables. We analysed whether such differences were already present in preschool children.; Swiss children from 84 childcare centres in five cantons (Aargau, Bern, Fribourg, Vaud, Zurich) comprising about 50% of the population of the country participated. Physical activity was quantified with accelerometers (ActiGraph, wGT3X-BT) and potential correlates were assessed with measurements at the childcare centre or questionnaires. Mixed regression models were used to test associations between potential correlates of total physical activity (TPA), moderate-to-vigorous physical activity (MVPA), light physical activity (LPA) or sedentary behaviour with a special focus on regional differences.; 394 of 476 children (83%) provided valid physical activity data (at least 2 weekdays and 1 weekend day with 10 h recording; mean age 3.9 ± 0.7 years, 54% boys) with 26% and 74% living in the French- and German-speaking parts of Switzerland, respectively. Days consisted of (mean ± standard deviation) 1.5 ± 0.5 h MVPA, 5.0 ± 0.6 h LPA, and 6.3 ± 0.8 h sedentary behaviour with an average of 624 ± 150 counts/min TPA. TPA and MVPA (but not sedentary behaviour or LPA) increased with age, were higher in boys and children with better motor skills. Despite controlling for individual characteristics, familial factors and childcare exposure, children from the French-speaking part of Switzerland showed 13% less TPA, 14% less MVPA, 6% less LPA and 8% more sedentary behaviour than German-speaking children.; Beside motor skills and non-modifiable individual factors, the regional sociocultural difference was the most important correlate of phyical activity and sedentary behaviour. Therefore, regionally adapted public health strategies may be needed

A systematic evaluation of physical activity and diet policies in Scotland : results from the 2021 Active Healthy Kids Report Card

Background: Policymaking regarding physical activity (PA) and diet plays an important role in childhood health promotion. This study provides a detailed examination of Scottish government and policy for child and adolescent PA and diet and discusses strengths and areas for improvement. Methods: Scottish policy documents (n = 18 [PA]; n = 10 [diet])—published in 2011–20—were reviewed for grading using an adapted version of the Health-Enhancing Physical Activity Policy Audit Tool Version 2. Results: There is clear evidence of leadership and commitment to improving PA and diet and tackling obesity in children and adolescents. The allocation of funds and resources for policy implementation has increased substantially over the past decade. Progress through early key stages of public policymaking—policy agenda and formation—has improved. However, there is limited information on later key stages, including policy monitoring and evaluation. Conclusions: Childhood PA and diet are a clear priority in Scotland, and PA and diet policies clearly support the desire to achieve other goals, including reducing inequalities and increasing active travel in Scotland. Nonetheless, future policies should be further strengthened through clear(er) plans of implementation, and monitoring and evaluation to support their societal impact

The Swiss Preschoolers’ health study (SPLASHY): objectives and design of a prospective multi-site cohort study assessing psychological and physiological health in young children

Background: Children’s psychological and physiological health can be summarized as the child’s thinking, feeling, behaving, eating, growing, and moving. Children’s psychological and physiological health conditions are influenced by today’s life challenges: Thus, stress exposure and lack of physical activity represent important health challenges in older children. However, corresponding evidence for young children is scarce. The aim of Swiss Preschoolers’ Health Study (SPLASHY) is to examine the role of stress and physical activity on children’s psychological and physiological health, particularly on cognitive functioning, psychological well-being, adiposity and motor skills in children at an early stage of childhood. We will also assess the role of child and environmental characteristics and aim to define sensitive time points. Methods/design: In a total of 84 child care centers, children at preschool age (2–6 years) are recruited and are assessed immediately and one year later. Assessments include direct measurements of the children in the child care centers and at home as well as assessments of children’s behavior and environmental factors through informants (parents and child care educators). Discussion: SPLASHY is one of the first studies in early childhood aiming to investigate the influence of stress and physical activity on children’s psychological and physiological health in a community-based longitudinal design

Evaluation of physical activity policies in Scotland : results from the 2021 Active Healthy Kids Scotland Report Card

Purpose: The benefits of physical activity (PA) are well-established for children and adolescents, and policy making regarding PA plays an important role in increasing PA. As part of the Active Healthy Kids Global Alliance initiative, the 2021 Active Healthy Kids Scotland Report Card summarised the status of PA and health in Scottish children and adolescents prior to the COVID-19 pandemic—reporting on a range of indicators (Bardid et al., 2022). This study provides a detailed examination of the evidence informing the Government and Policy indicator. Methods: Current Scottish PA policy documents (n=18) published in 2011-2020—not including responses to COVID-19—were reviewed for grading. The grade was determined using an adapted version of the Policy Audit Tool Version 2 (Ward et al., 2021). Key criteria in the scoring rubric include number and breadth of policies, identified funding, identifiable reporting structures, and monitoring and evaluation plan. Results: A C- grade was assigned to the Government and Policy indicator. There is clear evidence of leadership and commitment to increasing levels of PA and providing PA opportunities for children and youth. The allocation of funds and resources for implementation of policy has increased substantially since the publication of previous report cards. Progress through the key stages of public policymaking—policy agenda and formation—has improved. However, some policy documents do not identify accountable organisations, whilst others do not include details regarding reporting structures. Moreover, many policy documents do not provide information on monitoring and evaluation of policies. Conclusions: Scotland has many creditable policies at national level. There appears to be good links between the government and organisations accountable for implementation. Child and adolescent PA is clearly a priority in Scotland; it is not only an outcome, but also a means to achieve other goals (e.g., active travel to take climate action). However, current policies provide limited information on how delivery of proposed actions will be monitored and evaluated in practice. Future policies should therefore include more information on monitoring, evaluation, and reporting of delivery of actions, in order to better understand and support policy implementation and its impact on PA in children and adolescents

The relationship of parenting style and eating behavior in preschool children

Background: Eating behavior represents individual appetitive traits which are related to the individual's regulation of food intake. Eating behavior develops at an early age. There is some evidence that parenting styles might impact on the child's eating behavior. The aim of this study was to investigate the relationship of different dimensions of positive and negative parenting styles with the child's eating behavior at a critical age period of the child's early development. Methods: Parents of 511 preschool children (aged 2-6 years) completed the Children Eating Behavior Questionnaire and the Alabama Parenting Questionnaire. Results: Analyses revealed that different dimensions of negative parenting styles were associated with eating behavior of the child. In details, inconsistent parenting showed a consistent association with eating behavior of a child (i.e. higher emotional eating, higher food responsiveness, higher food fussiness, higher satiety responsiveness and more enjoyment of food), whereas corporal punishment was associated with more emotional overeating and more food responsiveness but less satiety responsiveness. Further, powerful implementation was related to higher food responsiveness and less enjoyment of food and low monitoring was associated with higher emotional overeating and more slowness in eating. There was no such consistent association of positive parenting and eating behavior. Conclusions: More negative parenting styles were associated with eating behavior which is more often related to potential weight problems in a long term, whereas positive parenting did not show such a consistent relationship with eating behavior. Negative parenting should be in the focus of prevention and treatment of eating behavior problems in young children. Trial registration: ISRCTN41045021 (06/05/2014). Keywords: Eating behavior; Parenting style; Preschool; SPLASH

Construction and validation of a test of oral direction in junior high school mathematics; discovering the degree of intelligence and achievement contained therein

Thesis (Ed.M.)--Boston Universit

Assessment of ocean color atmospheric correction methods and development of a regional ocean color operational dataset for the Baltic Sea based on Sentinel-3 OLCI

The Baltic Sea is characterized by large gradients in salinity, high concentrations of colored dissolved organic matter, and a phytoplankton phenology with two seasonal blooms. Satellite retrievals of chlorophyll-a concentration (chl-a) are hindered by the optical complexity of this basin and the reduced performance of the atmospheric correction in its highly absorbing waters. Within the development of a regional ocean color operational processing chain for the Baltic Sea based on Sentinel-3 Ocean and Land Colour Instrument (OLCI) full-resolution data, the performance of four atmospheric correction processors for the retrieval of remote-sensing reflectance (Rrs) was analyzed. Assessments based on three Aerosol Robotic Network-Ocean Color (AERONET-OC) sites and shipborne hyperspectral radiometers show that POLYMER was the best-performing processor in the visible spectral range, also providing a better spatial coverage compared with the other processors. Hence, OLCI Rrs spectra retrieved with POLYMER were chosen as input for a bio-optical ensemble scheme that computes chl-a as a weighted sum of different regional multilayer perceptron neural nets. This study also evaluated the operational Rrs and chl-a datasets for the Baltic Sea based on OC-CCI v.6. The chl-a retrievals based on OC-CCI v.6 and OLCI Rrs, assessed against in-situ chl-a measurements, yielded similar results (OC-CCI v.6: R2 = 0.11, bias = −0.22; OLCI: R2 = 0.16, bias = −0.03) using a common set of match-ups for the same period. Finally, an overall good agreement was found between chl-a retrievals from OLCI and OC-CCI v.6 although differences between Rrs were amplified in terms of chl-a estimates

Prevalence and Predictors of Behavioral Problems in Healthy Swiss Preschool Children Over a One Year Period

Behavioral problems impair children's health but prevalence rates are scarce and persistence rates vary due to divergence in age ranges, assessment methods and varying environmental factors. The aim of this study was to assess prevalence rates of behavioral problems, their persistence over a 1-year period, and the impact of child- and parent-related factors on behavioral problems. 555 2-6-year-old healthy preschool children were assessed at baseline and 382 of the initial sample at 1-year follow-up. Assessment included questionnaires concerning behavioral problems and their potential predictors (e.g. socio-economic status or parenting style). Altogether, nearly 7% of these children showed clinically relevant behavioral problems, and 3% showed persistent symptoms. Low SES, inconsistent parenting and corporal punishment were positively associated with behavioral problems. The prevalence rates of behavioral problems in Swiss preschoolers are similar to other European countries, but persistence is still rather low within preschool age. These findings need further confirmation in longitudinal studies