Length analysis of speech to be recorded in the recognition of Parkinson's disease

Parkinson's disease is an incurable neurodegenerative disease to the present clinical knowledge. It is diagnosed mostly by exclusion tests. Numerous studies have confirmed that speech can be promising to suspect the presence of the disease. On the other hand, just a few researches discuss the appropriate length of the speech sample or the contribution of parts of the full-length recordings in the classification. Hence, we partitioned each original recording into four shorter samples. We trained linear and radial basis function (rbf) kernel Support Vector Machine (SVM) models separately for original recordings, each partitioned group and all partitioned samples together. We found no significant difference between the results of the rbf kernel models. However, we obtained significantly better results with a portion of the entire speech using linear kernel models. In conclusion, even a shorter piece of a longer speech may be adequate for classification

Nehéz helyzetben a HEART Team: valve-in-valve implantáció? = HEART Team in trouble: valve-in-valve implantation?

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Szívtranszplantáció vagy abláció?: tachycardia-indukálta cardiomyopathia

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Szívtranszplantáció vagy abláció?: tachycardia-indukálta cardiomyopathia

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Characteristics, management, and outcomes of patients with multiple native valvular heart disease: a substudy of the EURObservational Research Programme Valvular Heart Disease II Survey

Aims To assess the characteristics, management, and survival of patients with multiple native valvular heart disease (VHD). Methods and results Among the 5087 patients with >= 1 severe left-sided native VHD included in the EURObservational VHD II Survey (maximum 3-month recruitment period per centre between January and August 2017 with a 6-month follow-up), 3571 had a single left-sided VHD (Group A, 70.2%), 363 had one severe left-sided VHD with moderate VHD of the other ipsilateral valve (Group B, 7.1%), and 1153 patients (22.7%) had >= 2 severe native VHDs (left-sided and/or tricuspid regurgitation, Group C). Patients with multiple VHD (Groups B and C) were more often women, had greater congestive heart failure (CHF) and comorbidity, higher left atrial volumes and pulmonary pressures, and lower ejection fraction than Group A patients (all P <= 0.01). During the index hospitalization, 36.7% of Group A (n = 1312), 26.7% of Group B (n = 97), and 32.7% of Group C (n = 377) underwent valvular intervention (P < 0.001). Six-month survival was better for Group A than for Group B or C (both P < 0.001), even after adjustment for age, sex, body mass index, and Charlson index [hazard ratio (HR) 95% confidence interval (CI) 1.62 (1.10-2.38) vs. Group B and HR 95% CI 1.72 (1.32-2.25) vs. Group C]. Groups B and C had more CHF at 6 months than Group A (both P < 0.001). Factors associated with mortality in Group C were age, CHF, and comorbidity (all P < 0.010). Conclusion Multiple VHD is common, encountered in nearly 30% of patients with left-sided native VHD, and associated with greater cardiac damage and leads to higher mortality and more heart failure at 6 months than single VHD, yet with lower rates of surgery