Ett gammalt kulturlandskap i Vindelfjällen : skogshistoria och markutnyttjande i Vuornavagge under 300 år

Humans have inhabited mountainous areas in northern Sweden since the end of the last glacial period, ca 8000 B.P., and their presence has marked the landscape in various ways. Older traces include the remains of hearths and dwelling sites, but there are also remains, such as culturally modified trees (CMT's), resulting from more recent activities in forested areas. This study aimed to document how people, both indigenous Sami's and Swedish settlers, have used an area northwest of Ammarnäs in Västerbotten, during the last 300 years, and what traces their activities have left in the area. I used historical records as well as an inventory of CMT's in the area to address this aim. Historical records of Sami activity are meagre, but it is clear that the people of the Ran and Gran Sami villages utilized the area long before 1500 A.D. Sami people peeled pine trees to use the inner bark as food and for storage of reindeer sinews, and the resultant Smi bark peelings can still be found in the forest. The first Swedish settlers in Ammarnäs arrived at the beginning of the 19th century, according to historical records. This is also indicated by trail markings and other CMT's and by evidence of haymaking. Both Sami and settlers utilized birch-bark as roof cover, as evidenced by birch-bark peelings in the area. There is also a trail though the area, which was make when the settlers were trading with Norway. During an inventory of the area, I discovered 220 CMT's of which 131 were birch-bark peelings and 29 were Sami bark peeling. However, during logging, which occurred around the 2nd World War, many old pines were removed, potentially removing and destroying a large proportion of the original Sami bark peelings. Of the CMT's documented during this study, the birch-bark peelings are the ones most likely to remain as a phenomenin, since they are still created by people using the birch-bark in handicraft. Our nature reserves have, as shown in this and in other studies, not only natural, but also cultural values. The mountain areas have a history many people have little knowledge about. The traces of old land use still left in these areas can give us further knowledge about the history of these areas, and we are obliged to save this cultural heritage for generations to come

Group rehabilitation of patients with acquired hearing impairment and their close relatives: Evaluation of short- and long-term effects

The aim of this study was to evaluate the effects of a two-weeks full-time group-rehabilitation program designed for hearing-impaired patients and their close relatives. Seventy-six consecutive patients in employment age (mean = 51 years; SD = 9 years, R = 22–64 years) with subjective need for audiological rehabilitation were included in the program. Pure tone averages were 46 dB HL and 58 dB HL at the low and high frequencies in the best ear, respectively. The patients responded to visual analogue scales (VAS) and questionnaires, intended to measure “perceived handicap”, “social support”, “perceived negative attitudes”, “acceptance of hearing loss” and “communication strategies”, before and after the last group session. The forms were also sent to the study group by post four and six months after the program was terminated. No significant short-term effects were found after the last group session, except that self-rated handicap in family life (VAS) was increased (p = 0.028), probably due to the participants’ increased awareness of hearing-related problems. Four months later, perceived negative attitudes from others were significantly reduced (p = 0.025), but self-rated handicap in family life was still increased (p = 0.023). Six months later (long-term effects), maladaptive strategies (e.g. guessing, pretending to hear and avoiding interactions) were significantly less often used (p = 0.036) and verbal strategies more frequently adopted (p = 0.018). This change of communication strategies might facilitate social participation and should therefore be seen as positive outcomes of a rehabilitation program

Green conversion of municipal solid wastes into fuels and chemicals

Presently, the society is facing a serious challenge for the effective management of the increasing amount of produced municipal solid wastes. The accumulated waste has caused a series of environmental problems such as uncontrolled release of greenhouse gases. Moreover, the increasing amount of wastes has resulted in a shortage of areas available for waste disposal, resulting in a nonsustainable waste management. These problems led to serious public concerns, which in turn resulted in political actions aiming to reduce the amount of wastes reaching the environment. These actions aim to promote sustainable waste management solutions. The main objective of these policies is to promote the recycling of municipal solid waste and the conversion of waste to energy and valuable chemicals. These conversions can be performed using either biological (e.g., anaerobic digestion) or thermochemical processes (e.g., pyrolysis). Research efforts during the last years have been fruitful, and many publications demonstrated the effective conversation of municipal solid waste to energy and chemicals. These processes are discussed in the current review article together with the change of the waste policy that was implemented in the EU during the last years

Blind Benchmark Exercise for Spent Nuclear Fuel Decay Heat

The decay heat rate of five spent nuclear fuel assemblies of the pressurized water reactor type were measured by calorimetry at the interim storage for spent nuclear fuel in Sweden. Calculations of the decay heat rate of the five assemblies were performed by 20 organizations using different codes and nuclear data libraries resulting in 31 results for each assembly, spanning most of the current state-of-the-art practice. The calculations were based on a selected subset of information, such as reactor operating history and fuel assembly properties. The relative difference between the measured and average calculated decay heat rate ranged from 0.6% to 3.3% for the five assemblies. The standard deviation of these relative differences ranged from 1.9% to 2.4%

Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis

<p>Abstract</p> <p>Background</p> <p>Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/1-mice. B10.Q-ncf1^*/*mice are B10.Q mice with a mutated Ncf1 gene. In B10.Q-ncf1^*/*mice, CIA develops as a chronic relapsing disease, which more accurately mimics human RA. We investigated the role of endogenous and exogenous sex steroids and raloxifene in the course of this model of chronic arthritis. We also examined whether treatment would prevent the development of inflammation-triggered generalized osteoporosis.</p> <p>Methods</p> <p>Female B10.Q-ncf1^*/*mice were sham-operated or ovariectomized, and CIA was induced. 22 days later, when 30% of the mice had developed arthritis, treatment with raloxifene, estradiol or vehicle was started, and the clinical disease was evaluated continuously. Treatment was continued until day 56 after immunization. At termination of the experiment (day 73), bone mineral density (BMD) was analyzed, paws were collected for histological examination, and sera were analyzed for markers of cartilage turnover and pro-inflammatory cytokines.</p> <p>Results</p> <p>Raloxifene and estradiol treatment, as well as endogenous estrogen, decreased the frequency of arthritis, prevented joint destruction and countered generalized osteoporosis. These effects were associated with lower serum levels of the pro-inflammatory cytokine IL-6.</p> <p>Conclusions</p> <p>This is the first study to show that raloxifene and estradiol can ameliorate established erosive arthritis and inflammation-triggered osteoporosis in this chronic arthritis model. We propose that treatment with raloxifene could be a beneficial addition to the treatment of postmenopausal RA.</p

Effekter på karbondynamikk, miljø og næring ved økt bruk av lukkede hogstformer

Miljødirektoratet har gitt NIBIO, NINA og NIVA i oppdrag å vurdere hvilken effekt økt bruk av lukkede hogstformer kan ha for karbonlagring i skog, biodiversitet, økologisk tilstand, vannkvalitet og skognæring. Oppdraget er utført ved hjelp av gjennomgang av relevant litteratur, data fra Landsskogtakseringen, modellbaserte simuleringer og ekspertvurderinger.Effekter på karbondynamikk, miljø og næring ved økt bruk av lukkede hogstformerpublishedVersio

Increased Recruitment but Impaired Function of Leukocytes during Inflammation in Mouse Models of Type 1 and Type 2 Diabetes

BACKGROUND: Patients suffering from diabetes show defective bacterial clearance. This study investigates the effects of elevated plasma glucose levels during diabetes on leukocyte recruitment and function in established models of inflammation. METHODOLOGY/PRINCIPAL FINDINGS: Diabetes was induced in C57Bl/6 mice by intravenous alloxan (causing severe hyperglycemia), or by high fat diet (moderate hyperglycemia). Leukocyte recruitment was studied in anaesthetized mice using intravital microscopy of exposed cremaster muscles, where numbers of rolling, adherent and emigrated leukocytes were quantified before and during exposure to the inflammatory chemokine MIP-2 (0.5 nM). During basal conditions, prior to addition of chemokine, the adherent and emigrated leukocytes were increased in both alloxan- (62±18% and 85±21%, respectively) and high fat diet-induced (77±25% and 86±17%, respectively) diabetes compared to control mice. MIP-2 induced leukocyte emigration in all groups, albeit significantly more cells emigrated in alloxan-treated mice (15.3±1.0) compared to control (8.0±1.1) mice. Bacterial clearance was followed for 10 days after subcutaneous injection of bioluminescent S. aureus using non-invasive IVIS imaging, and the inflammatory response was assessed by Myeloperoxidase-ELISA and confocal imaging. The phagocytic ability of leukocytes was assessed using LPS-coated fluorescent beads and flow cytometry. Despite efficient leukocyte recruitment, alloxan-treated mice demonstrated an impaired ability to clear bacterial infection, which we found correlated to a 50% decreased phagocytic ability of leukocytes in diabetic mice. CONCLUSIONS/SIGNIFICANCE: These results indicate that reduced ability to clear bacterial infections observed during experimentally induced diabetes is not due to reduced leukocyte recruitment since sustained hyperglycemia results in increased levels of adherent and emigrated leukocytes in mouse models of type 1 and type 2 diabetes. Instead, decreased phagocytic ability observed for leukocytes isolated from diabetic mice might account for the impaired bacterial clearance

Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals

BACKGROUND: Evidence from animal studies indicates the importance of an interaction between the sympathetic nervous system and the endothelium for cardiovascular regulation. However the interaction between these two systems remains largely unexplored in humans. The aim of this study was to investigate whether directly recorded sympathetic vasoconstrictor outflow is related to a surrogate marker of endothelial function in healthy individuals. METHODS AND RESULTS: In 10 healthy normotensive subjects (3 f/7 m), (age 37+/-11 yrs), (BMI 24+/-3 kg/m(2)) direct recordings of sympathetic action potentials to the muscle vascular bed (MSNA) were performed and endothelial function estimated with the Reactive Hyperaemia- Peripheral Arterial Tonometry (RH-PAT) technique. Blood samples were taken and time spent on leisure-time physical activities was estimated. In all subjects the rate between resting flow and the maximum flow, the Reactive Hyperemic index (RH-PAT index), was within the normal range (1.9-3.3) and MSNA was as expected for age and gender (13-44 burst/minute). RH-PAT index was inversely related to MSNA (r = -0.8, p = 0.005). RH-PAT index and MSNA were reciprocally related to time (h/week) spent on physical activity (p = 0.005 and p = 0.006 respectively) and platelet concentration (PLT) (p = 0.02 and p = 0.004 respectively). CONCLUSIONS: Our results show that sympathetic nerve activity is related to a surrogate marker of endothelial function in healthy normotensive individuals, indicating that sympathetic outflow may be modulated by changes in endothelial function. In this study time spent on physical activity is identified as a predictor of sympathetic nerve activity and endothelial function in a group of healthy individuals. The results are of importance in understanding mechanisms underlying sympathetic activation in conditions associated with endothelial dysfunction and emphasise the importance of a daily exercise routine for maintenance of cardiovascular health