955 research outputs found
Undulation instability in a bilayer lipid membrane due to electric field interaction with lipid dipoles
Bilayer lipid membranes [BLMs] are an essential component of all biological
systems, forming a functional barrier for cells and organelles from the
surrounding environment. The lipid molecules that form membranes contain both
permanent and induced dipoles, and an electric field can induce the formation
of pores when the transverse field is sufficiently strong (electroporation).
Here, a phenomenological free energy is constructed to model the response of a
BLM to a transverse static electric field. The model contains a continuum
description of the membrane dipoles and a coupling between the headgroup
dipoles and the membrane tilt. The membrane is found to become unstable through
buckling modes, which are weakly coupled to thickness fluctuations in the
membrane. The thickness fluctuations, along with the increase in interfacial
area produced by membrane buckling, increase the probability of localized
membrane breakdown, which may lead to pore formation. The instability is found
to depend strongly on the strength of the coupling between the dipolar
headgroups and the membrane tilt as well as the degree of dipolar ordering in
the membrane.Comment: 29 pages 8 fig
Unfolding dynamics of proteins under applied force
Understanding the mechanisms of protein folding is a major challenge that is being addressed effectively by collaboration between researchers in the physical and life sciences. Recently, it has become possible to mechanically unfold proteins by pulling on their two termini using local force probes such as the atomic force microscope. Here, we present data from experiments in which synthetic protein polymers designed to mimic naturally occurring polyproteins have been mechanically unfolded. For many years protein folding dynamics have been studied using chemical denaturation, and we therefore firstly discuss our mechanical unfolding data in the context of such experiments and show that the two unfolding mechanisms are not the same, at least for the proteins studied here. We also report unexpected observations that indicate a history effect in the observed unfolding forces of polymeric proteins and explain this in terms of the changing number of domains remaining to unfold and the increasing compliance of the lengthening unstructured polypeptide chain produced each time a domain unfolds
Phase Separation in Binary Fluid Mixtures with Continuously Ramped Temperature
We consider the demixing of a binary fluid mixture, under gravity, which is
steadily driven into a two phase region by slowly ramping the temperature. We
assume, as a first approximation, that the system remains spatially isothermal,
and examine the interplay of two competing nonlinearities. One of these arises
because the supersaturation is greatest far from the meniscus, creating
inversion of the density which can lead to fluid motion; although isothermal,
this is somewhat like the Benard problem (a single-phase fluid heated from
below). The other is the intrinsic diffusive instability which results either
in nucleation or in spinodal decomposition at large supersaturations.
Experimental results on a simple binary mixture show interesting oscillations
in heat capacity and optical properties for a wide range of ramp parameters. We
argue that these oscillations arise under conditions where both nonlinearities
are important
Loss of solutions in shear banding fluids in shear banding fluids driven by second normal stress differences
Edge fracture occurs frequently in non-Newtonian fluids. A similar
instability has often been reported at the free surface of fluids undergoing
shear banding, and leads to expulsion of the sample. In this paper the
distortion of the free surface of such a shear banding fluid is calculated by
balancing the surface tension against the second normal stresses induced in the
two shear bands, and simultaneously requiring a continuous and smooth meniscus.
We show that wormlike micelles typically retain meniscus integrity when shear
banding, but in some cases can lose integrity for a range of average applied
shear rates during which one expects shear banding. This meniscus fracture
would lead to ejection of the sample as the shear banding region is swept
through. We further show that entangled polymer solutions are expected to
display a propensity for fracture, because of their much larger second normal
stresses. These calculations are consistent with available data in the
literature. We also estimate the meniscus distortion of a three band
configuration, as has been observed in some wormlike micellar solutions in a
cone and plate geometry.Comment: 23 pages, to be published in Journal of Rheolog
The activation energy for GaAs/AlGaAs interdiffusion
Copyright 1997 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. This article appeared in Journal of Applied Physics 82, 4842 (1997) and may be found at
The Johnson-Segalman model with a diffusion term in Couette flow
We study the Johnson-Segalman (JS) model as a paradigm for some complex
fluids which are observed to phase separate, or ``shear-band'' in flow. We
analyze the behavior of this model in cylindrical Couette flow and demonstrate
the history dependence inherent in the local JS model. We add a simple gradient
term to the stress dynamics and demonstrate how this term breaks the degeneracy
of the local model and prescribes a much smaller (discrete, rather than
continuous) set of banded steady state solutions. We investigate some of the
effects of the curvature of Couette flow on the observable steady state
behavior and kinetics, and discuss some of the implications for metastability.Comment: 14 pp, to be published in Journal of Rheolog
Lattice Resistance and Peierls Stress in Finite-size Atomistic Dislocation Simulations
Atomistic computations of the Peierls stress in fcc metals are relatively
scarce. By way of contrast, there are many more atomistic computations for bcc
metals, as well as mixed discrete-continuum computations of the Peierls-Nabarro
type for fcc metals. One of the reasons for this is the low Peierls stresses in
fcc metals. Because atomistic computations of the Peierls stress take place in
finite simulation cells, image forces caused by boundaries must either be
relaxed or corrected for if system size independent results are to be obtained.
One of the approaches that has been developed for treating such boundary forces
is by computing them directly and subsequently subtracting their effects, as
developed by V. B. Shenoy and R. Phillips [Phil. Mag. A, 76 (1997) 367]. That
work was primarily analytic, and limited to screw dislocations and special
symmetric geometries. We extend that work to edge and mixed dislocations, and
to arbitrary two-dimensional geometries, through a numerical finite element
computation. We also describe a method for estimating the boundary forces
directly on the basis of atomistic calculations. We apply these methods to the
numerical measurement of the Peierls stress and lattice resistance curves for a
model aluminum (fcc) system using an embedded-atom potential.Comment: LaTeX 47 pages including 20 figure
Velocity profiles in shear-banding wormlike micelles
Using Dynamic Light Scattering in heterodyne mode, we measure velocity
profiles in a much studied system of wormlike micelles (CPCl/NaSal) known to
exhibit both shear-banding and stress plateau behavior. Our data provide
evidence for the simplest shear-banding scenario, according to which the
effective viscosity drop in the system is due to the nucleation and growth of a
highly sheared band in the gap, whose thickness linearly increases with the
imposed shear rate. We discuss various details of the velocity profiles in all
the regions of the flow curve and emphasize on the complex, non-Newtonian
nature of the flow in the highly sheared band.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Let
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