23 research outputs found
Gender and Age Differences in Patients' Satisfaction with Dental Care in the Slovak Republic: A Cross-sectional Questionnaire Study
Objective: To analyze the level of quality of healthcare satisfaction/dissatisfaction according to gender and age in terms of time spent with the doctor, communication, general satisfaction, interpersonal and financial aspects, technical quality and access/availability/convenience. Material and Methods: The standardized "Patient Satisfaction Questionnaire" (n=445) was collected in dental clinics in the Slovak Republic in the period of 2014-2015. The study sample was divided into subgroups according to gender (males: n=236; females: n=209) and age (<35 years: n= 243; ≥36 years: n=202). A scale from 1 (maximum dissatisfaction with quality of healthcare) to 5 (maximum satisfaction with quality of healthcare) was evaluated. Results: The highest significant satisfaction level of quality of healthcare (expressed as a mean score) were found in females in the subscale time spent with doctor (<35 y.) (2.90±0.69; p<0.042); the lowest satisfaction level was found in females (<35 y.) in the subscale general satisfaction (2.53±0.36; p=n.s.). Females (≥36y.) were significantly more satisfied with health care quality in the subscale communication than males (2.72±0.34 and 2.62±0.3, respectively; p=0.046). Males (<35 y.) were significantly less satisfied in the subscale technical quality compared to females (2.54±0.27 and 2.65±0.26, respectively; p=0.002). Conclusion: For the future, it is necessary to specify the next reasons for patients’ satisfaction/dissatisfaction with dental care
Characterization of Nuclear Polyhedrosis Virus DNA of Adoxophyes orana and of Barathra brassicae
The Analysis of Selected Malocclusion Risk Factors: A Pilot Study
Objective: To analyse selected malocclusion risk factors, their exposure time and overall malocclusion risk scores. Material and Methods: The self-prepared questionnaires were collected at dental practitioners’ waiting rooms from 6/2014 to 12/2015. The study group consisted of patients treated by dental braces (n=82; 15.5±4.4 years) and the control group consisted of other patients not treated by dental braces (n=45; 17.6±4.7 years). Data were processed by the statistical program SPSS using descriptive statistics. To verify the hypothesis wad used two sample t-test to compare the average exposure scores and the exposure time between the two groups. To determine associations between categorical variables was used Chi-square test. Statistical significance was set at p-value <0.05. Results: Our results confirmed longer exposure times in all studied malocclusion risk factors, in the case of pacifier sucking the difference was significant (p=0.001). The longest exposure time was found in mouth breathing in the study group (12.2±6.5 years). The lip sucking/chewing cannot be confirmed as a malocclusion risk factor. The study group had higher level of an overall mean risk score (19.8±11.5) compared the control group (16.1±12.1), although not significant. It can be concluded that non-nutritive sucking habits and/or mouth breathing could have damaging effect to normal teeth development. Conclusion: Malocclusions could be preventable, thus we recommend setting up educational programs for dentists and paediatricians as well as for parents focusing on the improvement of oral health knowledge
Impact of Orthodontic Treatment on Oral Health-Related Quality of Life in the Slovak Republic: A Cross-Sectional Study
The Risks of Social Noise Exposure in the Vulnerable Population in Slovakia
The study is aimed to quantify the effects of social noise exposure (personal music players (PMP), events with high noise exposure) and the exposure to the other environmental noise sources in the selected sample of Slovak university students. The validated ICBEN methodology was used to assess noise annoyance. The measurement of ambient noise levels was done using hand-held sound level analyzer. There were 526 university students (143 males and 383 females, average age 23 ± 2.2) enrolled into the study so far, 192 in the exposed housing facility to road traffic noise and 326 in the control housing facility in Bratislava. The social noise exposure was quantified and followed according to the authorized methodology of the study Ohrkan. From the total sample 416 (79.4%) students reported the use of PMP in the last week for the average time of 314 minutes. There was a significant difference in PMP use between the exposed (85.34%) and the control group (76.31%) (p = 0:01). Among PMP users 28.1% exceeded the LAV (lower action value for industry = 80 dB). The results showed the importance of road traffic and the social noise as well and the need for prevention and intervention in these vulnerable groups
Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide
Macroarray analysis in the hypertrophic left ventricle of renin-dependent hypertensive rats: identification of target genes for renin
Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
Background Germ cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy. As this might be caused by an increased capacity to repair CDDP-induced DNA damage, identification of DNA repair biomarkers predicting inadequate or aberrant response to CDDP, and thus poor prognosis for GCT patients, poses a challenge. The objective of this study is to examine the expression levels of the key nucleotide excision repair (NER) factors, XPA, ERCC1 and XPF, in GCT patients and cell lines. Methods Two hundred seven GCT patients’ specimens with sufficient follow-up clinical-pathological data and pairwise combinations of CDDP-resistant and -sensitive GCT cell lines were included. Immunohistochemistry was used to detect the ERCC1, XPF and XPA protein expression levels in GCT patients’ specimen and Western blot and qRT-PCR examined the protein and mRNA expression levels in GCT cell lines. Results GCT patients with low XPA expression had significantly better overall survival than patients with high expression (hazard ratio = 0.38, 95% confidence interval: 0.12–1.23, p = 0.0228). In addition, XPA expression was increased in the non-seminomatous histological subtype, IGCCCG poor prognosis group, increasing S stage, as well as the presence of lung, liver and non-pulmonary visceral metastases. Importantly, a correlation between inadequate or aberrant CDDP response and XPA expression found in GCT patients was also seen in GCT cell lines. Conclusions XPA expression is an additional independent prognostic biomarker for stratifying GCT patients, allowing for improvements in decision-making on treatment for those at high risk of refractoriness or relapse. In addition, it could represent a novel therapeutic target in GCTs