KINERJA PEGAWAI NEGERI SIPIL DALAM PELAYANAN PUBLIK SAAT PANDEMI COVID-19 DI KANTOR KECAMATAN TIKALA KOTA MANADO

This study aims to find out and examine in depth about the performance of civil servants in public services at the Tikala Sub-District Office during the Covid-19 pandemic. The method used in this research is descriptive qualitative research method. Sources of data used in this study are divided into two types, namely primary data and secondary data. The steps used in data analysis techniques are editing, data classification, then drawing conclusions. The results showed that the performance of civil servants at the Tikala sub-district office was not as expected, because the service during the pandemic was not the same as before the Covid-19 pandemic. Working from home during the Covid-19 pandemic did not go as expected, because the service activities at the Tikala District office were work that had to be completed at the office, not at home

Kajian Pencahayaan Alami pada Bangunan Villa Isola Bandung

Villa Isola is one of the relics of the colonial era buildings that function has changed from a resting into an office building Rektorat UPI Bandung. By changing the function of the office of Rector, the quality of natural lighting in the Villa Isola required to meet the activity going on inside the building. Studies of natural lighting in buildings Villa Isola aims to determine how much influence the openings on the quality of natural lighting. The selection is based on the object of study for the design of Villa Isola has a lot of openings in the facade so interesting to study the extent to which the building utilizes natural light into the room. Natural lighting is influenced by several variables: the design window openings, the shape and depth of space, visual comfort, and external factors. The method used in this study is the descriptive research method both qualitatively and quantitatively. From the analysis, the conclusion is obtained form the design and orientation of the window openings in the Villa Isola does not meet the quality standards of natural lighting

Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria

Background: There are no pharmacokinetic data of single low dose primaquine (SLDPQ) as transmission blocking in African children with acute Plasmodium falciparum and glucose-6-phosphate dehydrogenase deficiency (G6PDd). Methods: Primaquine pharmacokinetics of age-dosed SLDPQ (shown previously to be gametocytocidal with similar tolerability as placebo) were characterised in falciparum-infected Ugandan and Congolese children aged 6 months to 11 years, treated on admission with standard 3-day dihydroartemisinin-piperaquine or artemether-lumefantrine plus SLDPQ: 6 m–<1 y: 1.25 mg, 1–5 y: 2.5 mg, 6–9 y: 5 mg, 10–11 y: 7.5 mg. LC-MS/MS-measured plasma primaquine and carboxyprimaquine (baseline, 1, 1.5, 2, 4, 8, 12, 24 h) were analysed by noncompartmental analysis. Multivariable linear regression modelled associations between covariates, including cytochrome-P450 2D6 metaboliser status, and outcomes. Findings: 258 children (median age 5 [interquartile range (IQR) 3–7]) were sampled; 8 (3.1%) with early vomiting were excluded. Primaquine doses of 0.10–0.40 (median 0.21, IQR 0.16–0.25) mg base/kg resulted in primaquine maximum plasma concentrations (Cmax) of 2.3–447 (median 103.0, IQR 72.1–140.0) ng/mL between 1.0 and 8.0 (median 2) hours (Tmax) and median areas under the drug concentration curves (AUC0-last) 730.2 (6 m–<1 y, n = 12), 582.8 (1–5 y, n = 126), 871.1 (6–9 y, n = 80), and 931.0 (10–11 y, n = 32) ng∗h/mL. Median elimination half-live (T½) was 4.7 (IQR 3.8–5.6) hours. Primaquine clearance/kg peaked at 18 months, plateauing at 4 y. Increasing CYP2D6 metaboliser activity score [poor (3/250), intermediate (52/250), normal (150/250), ultrarapid (5/250), indeterminate (40/250)] and baseline haemoglobin were significantly associated with a lower primaquine AUC0-last,which increased with increasing mg/kg dose and age but was independent of the artemisinin treatment used. Interpretation: Age-dosed SLDPQ resulted in variable primaquine exposure that depended on bodyweight-adjusted dose, age, baseline haemoglobin and CYP2D6 metaboliser status, but not on dihydroartemisinin-piperaquine or artemether-lumefantrine. These data support age-dosed SLDPQ for transmission blocking in sub-Saharan Africa. Funding: This work was cofunded by the UK Medical Research Council, Wellcome Trust, and UK Aid through the Global Health Trials (grant reference MR/P006973/1). The funders had no role in the study design, execution, and analysis and decisions regarding publication

A beer a minute in Texas football: Heavy drinking and the heroizing of the antihero in Friday Night Lights

This article applies a qualitative framing analysis to the first three seasons of the television series Friday Night Lights, focusing particularly on its incorporation of heavy drinking into narrative representations of the player whose character is most consistently central to the game of football as fictionally mediated in small-town Texas over the course of those three seasons. The analysis suggests that over the course of that period Friday Night Lights embeds nuanced social meanings in its framing of alcohol use by that player and other characters so as to associate it with multiple potential outcomes. Yet among those outcomes, the most dominant framing works to, in effect, reverse a progression through which media representations historically evolved from a heroic model toward an antihero model, with heavy drinking central to that narrative process of meaning-making in such messages.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline