10 research outputs found
The Town Crier and the Quest for Social Justice in Ola Rotimi' s Plays
This paper sets out to review the role ..f the dramatist, particularly the Nigerian dramatist, as a social commentator and an advocate of social justice. Of all the creative artists, the dramatist, I believe, is in a better position to mirror his society. This is because his work has a unique characteristic of presenting events in a vivid, picturesque and realistic manner. This helps to facilitate the assimilation of social contradictions realistically in the minds of the audience. Its message is therefore immediate. It is devoid of the distant intimacy of prose; the often banal, sentimental, condensed and esoteric language of poetry; the cryptic and abstract message offine and applied arts; and the often incomplete and inconclusive society-the rich and the poor; the young and the old; the literate and the illiterate. This is so because through drama, the message is presented through acting or make-believe motions and gestures. How well has the Nigerian dramatist performed the role ? Ola Rotimi in his works seems to focus mainly on social injustice in the nation and the factors that hinder true unity in the country. His plays i1lclude: If (1990); Kurunmi(/988); Our Husband Has Gone Mad Again (1999), and Hopes of the Living Dead (1993). Through these plays he provides a vision that could inspire the formulation of positive government policies, which if implemented properly, would lead to genuine national unity in Nigeria
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Characterization of Statin Dose Response in Electronic Medical Records
Efforts to define the genetic architecture underlying variable statin response have met with limited success, possibly because previous studies were limited to effect based on a single dose. We leveraged electronic medical records (EMRs) to extract potency (ED50) and efficacy (Emax) of statin dose-response curves and tested them for association with 144 preselected variants. Two large biobanks were used to construct dose-response curves for 2,026 and 2,252 subjects on simvastatin and atorvastatin, respectively. Atorvastatin was more efficacious, was more potent, and demonstrated less interindividual variability than simvastatin. A pharmacodynamic variant emerging from randomized trials (PRDM16) was associated with Emax for both. For atorvastatin, Emax was 51.7 mg/dl in subjects homozygous for the minor allele vs. 75.0 mg/dl for those homozygous for the major allele. We also identified several loci associated with ED50. The extraction of rigorously defined traits from EMRs for pharmacogenetic studies represents a promising approach to further understand the genetic factors contributing to drug response