AN EMPIRICAL STUDY OF TIME-SERIES ANALYSIS IN MARKETING MODEL BUILDING.

Abstract not availabl

Effet de l’allongement de la chaine aliphatique sur l’autoassociation des alcools primaires, secondaires et tertiaires

Ou a mesuré les coefficients de partage des alcools : propanol-1, butanol-1, pentanol-1, isobutanol, propanol-2, butanol-2, pentanol-2, tertiobutanol et tertiopentanol entre le cyclohexane et l’eau, à 25 °C. De ces coefficients on a déduit, suivant une méthode décrite antérieurement, le degré moyen d’association [math] et la fraction des molécules non-associées a, dans la phase organique. En utilisant l’équation de BUCHOWSKY ces données permettent également de calculer le rapport du nombre réel d’entités au nombre formel de molécules Ʃαn. Par spectrométrie infrarouge on a déterminé le rapport entre le nombre de groupe O — H « libres » et le nombre formel de molécules Ʃαn, o. A une même concentration le degré moyen d’association nw est d’autant plus faible et α1, Ʃαn, osont d’autant plus élevés que l’alcool est plus lourd ou plus ramifié, ou que pour des isomères on suive la séquence : primaire, secondaire, tertiaire.On a estimé la valeur moyenne de la constante d’équilibre kM d’addition d’une molécule supplémentaire à partir de α1, en utilisant l’approximation de MECKE-KEMPTER. Dans l’intervalle de concentration de 0,05 à 4 moles par litre ces valeurs restent constantes à 20 % près. A partir de la valeur moyenne de kM on estime les valeurs des paramètres [math] et nN (nombre moyen de molécules par entité) caractérisant l’association des alcools à l’état pur. Ces résultats sont confrontés avec ceux obtenus par des méthodes différentes. Quoique des écarts de l’oidre de 50 % puissent apparaître, les trois méthodes confirment l’effet de la longueur de la chaîne aliphatique et de la structure de la molécule sur l'association des alcools purs

Structural basis for difference in heat capacity increments for Ca(2+) binding to two alpha-lactalbumins.

Thermodynamic parameters for the unfolding of as well as for the binding of Ca(2+) to goat alpha-lactalbumin (GLA) and bovine alpha-lactalbumin (BLA) are deduced from isothermal titration calorimetry in a buffer containing 10 mM Tris-HCl, pH 7.5 near 25 degrees C. Among the different parameters available, the heat capacity increments (Delta C(p)) offer the most direct information for the associated conformational changes of the protein variants. The Delta C(p) values for the transition from the native to the molten globule state are rather similar for both proteins, indicating that the extent of the corresponding conformational change is nearly identical. However, the respective Delta C(p) values for the binding of Ca(2+) are clearly different. The data suggest that a distinct protein region is more sensitive to a Ca(2+)-dependent conformational change in BLA than is the case in GLA. By analysis of the tertiary structure we observed an extensive accumulation of negatively charged amino acids near the Ca(2+)-binding site of BLA. In GLA, the cluster of negative charges is reduced by the substitution of Glu-11 by Lys. The observed difference in Delta C(p) values for the binding of Ca(2+) is presumably in part related to this difference in charge distribution

Gynecologic cancers in pregnancy: guidelines of an international consensus meeting.

Contains fulltext : 80545.pdf (publisher's version ) (Closed access

In utero exposure to chemotherapy : effect on cardiac and neurologic outcome.

This study consisted of two parts. Firstly, in a multicenter retrospective study women who received chemotherapy during pregnancy were recruited from four different Belgian centers. Clinical data were obtained through a questionnaire. Obstetric and perinatal data did not differ from earlier reported larger series and suggest morbidity after intrauterine exposure to cytotoxic drugs mainly appears to be related to (induced) prematurity. Nine pregnant women, 25 years to 39 years of age (median, 31 years), of whom one was having a twin pregnancy, had been treated with chemotherapy for different malignant disorders (four breast cancer, two acute myeloid, one lymphoblastic leukemia, one cervical cancer, and one undifferentiated oropharyngeal tumor). Cancer was diagnosed between 12 weeks and 24 weeks (median, 17 weeks) of pregnancy. Thirty-three cycles of antineoplastic drugs were administered between 15 weeks and 35 weeks (median, 25 weeks). Different types of chemotherapeutic regimens were administered. In seven cases, anthracyclines were used with a mean total cumulative dose of 240 mg/m*2. In the second and prospective part of the study, all children were invited for a full neurologic and cardiologic assessment. This assessment consisted of neurologic clinical evaluations by the same pediatric neurologist (L.L.). Standard echocardiographic data acquisition consisted of a standard transthoracic echocardiogram (to measure ventricular dimensions, mass, wall thickness, and fractional shortening) and blood pool Doppler (to assess diastolic function). Color Doppler myocardial imaging was performed from the inferolateral wall, interventricular septum, the left ventricular lateral, and the right ventricular free wall as previously explained to calculate myocardial deformation (peak systolic strain and strain rate). The examinations were performed by the same pediatric cardiologist (L.M.). Echocardiographic data were compared with those of an age- and sex-matched control group consisting of 10 healthy children