TALON and CRADLE: Systems for the rescue of tumbling spacecraft and astronauts

Advanced pressure suit and tool designs are beginning to allow extravehicular astronauts to repair space vehicles and so increase mission life and system reliability. A common spacecraft failure that is a severe challenge to the rescue mission planner is loss of attitude control resulting in tumbling motion. If an extravehicular astronaut flying the Manned Maneuvering Unit (MMU) 'falls' into a tumble, the result could be loss of life. TALON (Tumble Arresting Large Oscillation Nullifier) is a device capable of capturing a target in an uncontrolled three-axis tumble. CRADLE (Concentric Rotating Astronaut Detumble Lifesaving Equipment) is a similar device sized to rescue a suited astronaut. The two rescue vehicles work on the same basic principle. They are structural shells with articulated limbs which can surround a tumbling target and thus align both the chaser and target centers of mass (CM)

Species difference in the conjugation of some aromatic acids

Imperial Users onl

Walking to Work: Community and Contact

The settler community must negotiate the difference of the stranger and the melancholy and violence of a past haunted by colonization and death. Through writing the details of everyday contact in a walk across the city this essay explores notions of community. It owes much to the writing of Linnell Secomb who writes of the haunted nature of the settler community in the Australian context. Secomb writes of community through the ideas of Jean Luc Nancy where community is a process of negotiation of difference, a listening to the unfamiliar other in conflict and acceptance. The work of Alphonso Lingis and Richard Sennett has informed my ideas of the stranger and the city while Kim Scott’s “Benang” has influenced how I think and write about the echo of the past in the present. These theoretical interruptions punctuate this writing of negotiating community

The Idle Wall Restaurant Menu 2017

The Idle Wall restaurant at The Quay in Westport, Co. Mayo sits on the path of the Western Way and the Greenway trail. A visit to the West of Ireland is not complete with stopping a while to dine at The Idle Wall. Chef Áine Maguire “rewrote the book on using the raw ingredients of Ireland’s culinary foodways … she took the foods of her childhood… and made them irresistible” John & Sally McKennas’ Guides 2014https://arrow.tudublin.ie/menus21c/1187/thumbnail.jp

The metabolomic profile of gamma-irradiated human hepatoma and muscle cells reveals metabolic changes consistent with the Warburg effect

The two human cell lines HepG2 from hepatoma and HMCL-7304 from striated muscle were γ-irradiated with doses between 0 and 4 Gy. Abundant γH2AX foci were observed at 4 Gy after 4 h of culture post-irradiation. Sham-irradiated cells showed no γH2AX foci and therefore no signs of radiation-induced double-strand DNA breaks. Flow cytometry indicated that 41.5% of HepG2 cells were in G2/M and this rose statistically significantly with increasing radiation dose reaching a plateau at ∼47%. Cell lysates from both cell lines were subjected to metabolomic analysis using Gas Chromatography-Mass Spectrometry (GCMS). A total of 46 metabolites could be identified by GCMS in HepG2 cell lysates and 29 in HMCL-7304 lysates, most of which occurred in HepG2 cells. Principal Components Analysis (PCA) showed a clear separation of sham, 1, 2 and 4 Gy doses. Orthogonal Projection to Latent Structures-Discriminant Analysis (OPLS-DA) revealed elevations in intracellular lactate, alanine, glucose, glucose 6-phosphate, fructose and 5-oxoproline, which were found by univariate statistics to be highly statistically significantly elevated at both 2 and 4 Gy compared with sham irradiated cells. These findings suggested upregulation of cytosolic aerobic glycolysis (the Warburg effect), with potential shunting of glucose through aldose reductase in the polyol pathway, and consumption of reduced Glutathione (GSH) due to γ-irradiation. In HMCL-7304 myotubes, a putative Warburg effect was also observed only at 2 Gy, albeit a lesser magnitude than in HepG2 cells. It is anticipated that these novel metabolic perturbations following γ-irradiation of cultured cells will lead to a fuller understanding of the mechanisms of tissue damage following ionizing radiation exposure