Liquid phase pulsed laser ablation: a route to fabricate different carbon nanostructures

Carbon nanostructures in various forms and sizes, and with different speciation properties have been prepared from graphite by Liquid Phase - Pulsed Laser Ablation (LP-PLA) using a high frequency Nd:YAG laser. High energy densities and pulse repetition frequencies of up to 10 kHz were used in this ablation process to produce carbon nanomaterials with unique chemical structures. Dynamic Light Scattering (DLS), micro-Raman and High-Resolution Transmission Electron Microscopy (HRTEM) were used to confirm the size distribution, morphology, chemical bonding, and crystallinity of these nanostructures. This article demonstrates how the fabrication process affects measured characteristics of the produced carbon nanomaterials. The obtained particle properties have potential use for various applications including biochemical speciation applications

The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01–4·94) deaths and 105 million (95·0–116) DALYs for both sexes combined, representing 44·4% (41·3–48·4) of all cancer deaths and 42·0% (39·1–45·6) of all DALYs. There were 2·88 million (2·60–3·18) risk-attributable cancer deaths in males (50·6% [47·8–54·1] of all male cancer deaths) and 1·58 million (1·36–1·84) risk-attributable cancer deaths in females (36·3% [32·5–41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6–28·4) and DALYs by 16·8% (8·8–25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9–42·8] and 33·3% [25·8–42·0]). INTERPRETATION: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Settling behavior of fine cuttings in fiber-containing polyanionic fluids for drilling and hole cleaning application

For efficient drilling operations, cuttings transport within the oil and gas wellbore is fundamental. Inadequate hole cleaning results in many problems including reduced rate of penetration, increased torque, bit wearing, and stuck pipe. The addition of fiber aids the cleaning performance of drilling sweep with a minor change in fluid rheology. However, our understanding of this complex fluid is very limited. Especially, the impact of polymer anionicity (solution negative charge density) on the hole cleaning performance of these fluids has not been investigated. The objective of this work is to examine the effect of anionicity and fiber on cutting carrying capacity of polymeric suspensions. This study presents results of an experimental study conducted on the settling behavior of fine cuttings in base fluids with the addition of polymers such as xanthan gum (XG), carboxymethyl cellulose (CMC), and polyanionic cellulose (PAC), and inert fibers. Moreover, the effect of cutting sizes (0.125 and 0.250 mm) was also assessed. Results showed that, in addition to the viscosity, the anionicity of base polymer influences the carrying capacity of the suspensions. The increase in anionicity improved the cutting carrying capacity of suspensions as indicated by Total Suspended Solids (TSS) measurements. The improvement of carrying capacity due to polymer anionicity is because of increased particle-particle and particle-polymer repulsion forces. Besides this, a small amount of fiber (0.08%) added to the base fluids enhanced the carrying capacity with minimal effect on fluid rheology. The enhancement due to fiber originates from the mechanical hindering effect of the fiber network and hydrodynamic interactions between cuttings and fibers. This study findings reveal that the hole cleaning performance of water-based drilling fluids with fine cuttings (0.063?0.500 mm) can be improved by increasing base fluid anionicity and adding fibers.This work was made possible by the support of a National Priorities Research Program (NPRP) grant from the Qatar National Research Fund (QNRF) , grant reference number NPRP11S-1228 170140 . We would like to recognize Central Laboratory Unit (CLU) at Qatar University for carrying out the SEM-EDX test. The statements made herein are solely the responsibility of the authors. This work was also supported by Qatar national Library . Open Access funding provided by the Qatar National Library .Scopu

Application of response surface methodology and box-behnken design for the optimization of the stability of fibrous dispersion used in drilling and completion operations

Fibers are extensively used as a fluid additive in the oil and gas industry to improve hole-cleaning performance, control fluid filtration loss, and enhance hydraulic fracturing effectiveness. Generally, a small amount of fiber is dispersed in the base fluid to achieve the desired results without increasing the viscosity of the base fluid. Nevertheless, sustaining a uniform fiber dispersion can be challenging under wellbore conditions, which is essential for fibers’ functionality. Consequently, a better understanding of fiber suspension or stability in base fluids is necessary for their efficient utilization in drilling and completion operations. In this study, response surface methodology (RSM) and box–behnken design (BBD) are used to investigate the stability of fiber in polymeric base suspensions, including carboxy methyl cellulose (CMC), polyacrylamide (PAM), and xanthan gum (XG). The BBD of three factors was selected to observe the influence of polymer concentration, fiber concentration, and temperature on fibrous suspension stability, with three levels of design factors (low, mid, and high) and two fiber aspect ratios (3 and 12 mm fibers). The base fluid polymer concentration ranged from 1 to 8 vol %, fiber concentration ranged from 0.01 to 0.08 wt %, and the temperature was varied from 25 to 80 °C. The stability measurements were analyzed using Minitab, subsequently, evaluating the factors’ impact and interactions and determining the optimum conditions for the stability of the fibrous suspensions. The results predicted by the developed model were in good agreement with the experimental results R2 ≥ 0.91–0.99. The sensitivity analysis showed that base fluid polymer concentration is the most significant factor affecting fibrous suspension stability. At high polymer concentrations, fiber concentration and temperature effects are minimal, while the temperature effect on the stability was observed at low concentrations (e.g., low suspension viscosities). The fiber aspect ratio indirectly affects system stability. Long fibers have a better tendency to entangle and form a structured network, which in turn hinders the buoyancy that induces individual fiber migration. On the contrary, short fibers do not form a network, allowing them to easily migrate to the surface and agglomerate at the top layer (unstable region). Optimization results revealed that suspensions with viscosities above 50 mPa·s are sufficient to maintain the stability of the suspensions at ambient (25 °C) and elevated (80 °C) temperatures.This work was made possible by the support of a National Priorities Research Program (NPRP) grant from the Qatar National Research Fund (QNRF), grant reference number NPRP11S-1228 170140. The statements made herein are solely the responsibility of the authors. The authors would also like to thank with gratitude SNF Floerger Company for supplying the PAM samples.Scopu

Evaluation of Chitosan/Fructose Model as an Antioxidant and Antimicrobial Agent for Shelf Life Extension of Beef Meat During Freezing

In the present study the effect of chitosan/fructose Maillard reaction products (CF-MRPs) as antioxidant and antimicrobial agents was evaluated and applied on minced beef meat during frozen storage. Antioxidant and antimicrobial properties of chitosan-fructose complexes were tested. Anti-oxidant properties were measured by the DPPH, β-carotene and ABTS methods. These three methods showed the same profile of antioxidant activity. Chitosan with 4% fructose autoclaved for 45 min (CF9) showed to have the most effective antioxidant activity. It was demonstrated that the browning product exhibited antioxidant activity. For antimicrobial activity, most chitosan-fructose complexes were less effective than chitosan. Thus, MRPs derived from chitosan-sugar model system can be promoted as a novel antioxidant to prevent lipid oxidation in minced beef. Chitosan-sugar complex could be a potential alternative natural product for synthetic food additive replacement that would additionally meet consumer safety requirement