Identifying and measuring management deficiency in non-profit associations.

The need to measure the performance of non-profit committees has been recognised for over 30 years primarily because of the direct relationship between committee performance and association performance but also because identifying management strengths and weaknesses across a range of performance factors forms the basis for an effective management development programme. The results of past studies are generally inconclusive leading to a lack of consensus as to which is the best approach. The objective for this study was to demonstrate that a heuristic methodology does produce an acceptable, approximate solution to the measurement of individual management performance in a non-profit committee. Testing established that the heuristic model produced a satisfactory solution and was able to provide a detailed assessment of management strengths and weaknesses across a wide range of factors. The solution produced by the model was validated by demonstrating that there was an alignment of the results produced by the heuristic model and those obtained by an alternate method. Analysis of the results obtained from a sample of non-profit committee members provided clear evidence that management skills, management experience, relevant knowledge and commitment are key competencies for non-profit committee members. The level of deficiency in these factors will directly affect the level of individual and committee management deficiency. A direct, positive relationship between age and management performance was also identified. The findings suggest that, in general, the competencies required to manage the affairs of smaller non-profit associations are concentrated in one or two individuals. Within these individuals, a high level of experience gained from years of serving on the committee, combined with the accumulated knowledge of the association’s culture, norms and management processes, forms the means by which the association is managed. This research provides a platform from which the scope of the model can be extended to make it applicable to larger associations and provide global access to the model through the development of an on-line application. The heuristic methodology employed in this study could be used to find a solution to another important problem in the non-profit field: measuring the performance of a non-profit association in achieving its objectives

Anniella

Number of Pages: 11Integrative BiologyGeological Science

The Ursinus Weekly, May 21, 1956

Gladfelter to be speaker at Commencement on June 4 • Baccalaureate to be conducted by Methodist bishop • Scout fraternity inducts members at banquet • Jones and Donia write new UC song • Frosh choose soph rulers for Fall • Football squad meets; Plans for Fall season • Dean Pancoast to receive Ph.D. • Creager to speak at clergy confab • Chess Club holds election • Bell schedule for exams • Construction to begin soon on Paisley, Stauffer, and Beardwood dormitories • Miss Stahr cited for DPA award • KDK votes for officers • WSGA officers, members installed at banquet • Pi Gamma Mu chooses members, has election • Apes elect new officers • Editorial: Black is still not white; A gem of a Ruby • U.C. says hi to English visitor • My trip to a grad research center • Tau Sig elects new leaders • Officers of O Chi chosen • Two frat pinnings announced • Neborak cops most outstanding athlete award at annual Varsity Club banquet Mon. • Netgals beat Penn; Drop only loss to Bryn Mawr, 3-2 • Bears beat Mules; Seven marks set as Lehigh romps • Bruins stopped by Dutchmen, LaSalle, Smash Rutgers; 19-1 • Netmen top Hens, LaSalle & Houndshttps://digitalcommons.ursinus.edu/weekly/1453/thumbnail.jp

Appropriate Methodologies to Better Measure Consumer Preferences for Postal Services

This report summarises work undertaken testing the use of stated preference discrete choice experiments to measure consumer preferences for postal services. It discusses the importance of understanding and quantifying consumer priorities in the postal sector and presents different methods used for valuing non-market goods. We recommend the use of stated preference discrete choice experiments, and test the use of this approach in three member states. We provide the findings for these member states, as well as a “tool kit” for applying this methodology in other member states in future.Consumer preferences, postal services, discrete choice, two-sided market

The Ursinus Weekly, April 9, 1956

Blossom time, Junior Prom is blooming success Fri. Nite • Student-Faculty show, Fri. night • Ursinus Weekly chooses new staff • National music fraternity receives new members • Seven new Cub and Key men chosen; Sonnie Kruse elected Jr. Prom queen • Men\u27s government plans joint confab; Discusses merger • Alpha Psi Omega to do play excerpt for WFIL-TV • APO makes plans for trip, banquet • Editorial: It\u27s not the publicity; It\u27s the action • Poll results, Campus Chest fund plans are announced • Albert Thompson speaker at Forum • Editorial: Let Campus Chest speak for itself • Letters to the editor • Chest receipts do help a million! • Any money left? Aid Ugly Man race • Guilt by association is real threat to academic freedom • Rain spoils opener with Albright; Slotter to face Drexel Wednesday • Girls tennis team boast frosh power • Gros again sparks victory as Belles cop first undefeated season in twenty years • Curtis captures IM crown; IFC track meet held Thursday • WSGA urges students to keep Ursinus green • Mr. H. Lloyd Jones advisor to Weekly • Making corsages optional; Might prove worthwhile • Grocery slips aid SRC; Half-way mark reachedhttps://digitalcommons.ursinus.edu/weekly/1447/thumbnail.jp

Evolution of an expanded mannose receptor gene family

Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B. Inspection of the genomic environment of the chicken gene revealed an array of five paralogous genes, MRC1L-A to MRC1L-E, located between conserved flanking genes found either side of the single MRC1 gene in mammals. Transcripts of all five genes were detected in RNA from a macrophage cell line and other RNAs, whose sequences allowed the precise definition of spliced exons, confirming or correcting existing bioinformatic annotation. The confirmed gene structures were used to locate orthologues of all five genes in the genomes of two other avian species and of the painted turtle, all with intact coding sequences. The lizard genome had only three genes, one orthologue of MRC1L-A and two orthologues of the MRC1L-B antigen gene resulting from a recent duplication. The Xenopus genome, like that of most mammals, had only a single MRC1-like gene at the corresponding locus. MRC1L-A and MRC1L-B genes had similar cytoplasmic regions that may be indicative of similar subcellular migration and functions. Cytoplasmic regions of the other three genes were very divergent, possibly indicating the evolution of a new functional repertoire for this family of molecules, which might include novel interactions with pathogens

The rotational profiles of cluster galaxies

© 2019 The Author(s) We compile two samples of cluster galaxies with complimentary hydrodynamic and N-body analysis using FLASH code to ascertain how their differing populations drive their rotational profiles and to better understand their dynamical histories.We select our main cluster sample from the X-ray Galaxy Clusters Database (BAX), which are populated with Sloan Digital Sky Survey (SDSS) galaxies. The BAX clusters are tested for the presence of substructures, acting as proxies for core mergers, culminating in sub-samples of eight merging and 25 non-merging galaxy clusters. An additional sample of 12 galaxy clusters with known dumbbell components is procured using galaxy data from the NASA/IPAC Extragalactic Database (NED) to compare against more extreme environments. BAX clusters of each sample are stacked on to a common RA-Dec. space to produce rotational profiles within the range of 0.0-2.5 r200. Merging stacks possess stronger core rotation at ≲0.5r200 primarily contributed by a red galaxy sub-population from relaxing core mergers; this is alongside high rotational velocities from blue galaxy sub-populations, until they mix and homogenize with the red sub-populations at ∼r200, indicative of an infalling blue galaxy sub-population with interactive mixing between both sub-populations at ≿ r200. FLASH code is utilized to simulate the merger phase between two originally independent clusters and test the evolution of their rotational profiles. Comparisons with the dumbbell clusters leads to the inference that the peculiar core rotations of some dumbbell clusters are the result of the linear motions of core galaxies relaxing on to the potential during post second infall

Effects of injection marination with various calcium sources and molar concentrations on display color life, tenderness, and microbial inhibition of beef loin steaks

Beef strip loins were assigned to one of 11 treatments that included injection marination (10% by weight) with three calcium salts at three molar concentrations, a distilled water control, and a non-marinated control. The effects of calcium salt and concentration were tested for retail display color life, tenderness and sensory traits, and microbial growth. Calcium lactate marinated steaks had longer color life and less microbial growth than those treated with calcium chloride or calcium ascorbate. Increasing molar concentration (.1M to .2M to .3M) caused faster color deterioration, and did not significantly improve microbial inhibition. All calcium treatments improved tenderness; however, calcium chloride treatments induced off-flavors. Considering a whole system approach that accounts for color life, microbial inhibition, shear force, and sensory traits, we recommend injecting beef longissimus with 10% of a .1M solution of calcium lactate, and do not recommend other calcium salts or concentrations

Safety, Tolerability, and Pharmacokinetic Properties of Intravenous Delafloxacin After Single and Multiple Doses in Healthy Volunteers

AbstractPurposeThe objective of this report was to determine the pharmacokinetic properties, safety, and tolerability of single and multiple doses of intravenous delafloxacin. In addition, the absolute bioavailability (BA) of the 450-mg tablet formulation of delafloxacin was determined.MethodsThree clinical trials are summarized. The first study was a randomized, double-blind, placebo-controlled, single- (300, 450, 600, 750, 900, and 1200 mg) ascending-dose study of IV delafloxacin in 62 (52 active, 10 placebo) healthy volunteers. The second study was a randomized, double-blind, placebo-controlled study of IV delafloxacin (300 mg) given as a single dose on day 1, followed by twice-daily dosing on days 2 through 14; 12 (8 active, 4 placebo) healthy volunteers were enrolled. The third study was an open-label, randomized, 2-period, 2-sequence crossover study in which 56 healthy volunteers were randomly assigned to 1 of 2 sequences of a single oral dose of delafloxacin (450-mg tablet) or IV delafloxacin (300 mg). Serial blood samples were collected, and plasma pharmacokinetic parameters of delafloxacin were calculated.FindingsDelafloxacin Cmax values increased proportionally with increasing single IV dose for the dose range of 300 to 1200 mg, whereas the AUC values increased more than proportionally to dose for the same dose range. The mean terminal half-life of delafloxacin was approximately 12 hours (ranging from 8 to 17 hours). The volume of distribution (Vd) at steady state was approximately 35 L, which is similar to the volume of total body water. There was minimal accumulation of delafloxacin after twice-daily IV administration of 300 mg with an accumulation ratio of 1.09. The delafloxacin total exposure after a single 1-hour IV infusion of 300 mg and a single oral dose of a 450-mg tablet were equivalent with geometric least square mean ratio (90% CI) of 0.8768 (0.8356–0.9200) for AUC0–∞ and 0.8445 (0.8090–0.8815) for AUC0–t, respectively. The Cmax values of delafloxacin were not equivalent for the 2 formulations with a ratio (90% CI) of 0.5516 (0.5150–0.5908), respectively. The mean absolute bioavailability of delafloxacin was 58.8%.ImplicationsDelafloxacin was well tolerated in healthy volunteers after single and multiple IV doses. The total systemic exposure to IV (300 mg) and oral (450 mg) delafloxacin is comparable, supporting that a switch between the 2 formulations is appropriate

Single and Multiple Ascending-dose Studies of Oral Delafloxacin: Effects of Food, Sex, and Age

AbstractPurposeThe objective of this report is describe the results of 2 studies that examined the pharmacokinetic parameters, safety profile, and tolerability of single and multiple ascending doses of oral delafloxacin and the effects of food, sex, and age on oral delafloxacin pharmacokinetic parameters, safety profile, and tolerability.MethodsThe first study contained 3 parts and used unformulated delafloxacin in a capsule. Part 1 was a randomized, double-blind, placebo-controlled, single (50, 100, 200, 400, 800, 1200, and 1600 mg) ascending-dose study of oral delafloxacin in healthy men. Part 2 was a single-dose crossover study in which 20 men received 250 mg delafloxacin with or without food. Part 2 also included a parallel group, double-blind, placebo-controlled study in 16 women and 16 elderly men and women who were randomized (3:1) to receive 250 mg delafloxacin or placebo. Part 3 was a randomized, double-blind, placebo-controlled, multiple (100, 200, 400, 800, 1200 mg once daily for 5 days) ascending-dose study of oral delafloxacin in healthy men. The second study was a single-dose, randomized, 3-period crossover study in which participants received 900 mg delafloxacin (2 × 450-mg tablets) under fasted conditions, with a high-fat meal, or fasted with a high-fat meal 2 hours after dosing. Serial blood samples were collected, and plasma pharmacokinetic parameters of delafloxacin were determined.FindingsDelafloxacin Cmax and AUC0–∞ increased with increasing oral dose over the dose range of 50 to 1600 mg. The increases in delafloxacin AUC0–∞ were dose proportional at doses of ≥200 mg. Steady state was reached by day 3 of dosing with minimal accumulation of delafloxacin. The Cmax of delafloxacin was decreased slightly in the presence of food. No sex difference in delafloxacin pharmacokinetic parameters was observed. In the elderly men and women, mean delafloxacin Cmax and AUC0–∞ were 35% higher than observed for young adults, which could be partially explained by a decrease in the creatinine clearance in the elderly men and women. Delafloxacin was well tolerated at the tested doses, with gastrointestinal adverse effects observed more commonly at doses ≥1200 mg.ImplicationsDelafloxacin exhibits linear pharmacokinetic parameters that reached steady state after 3 days of daily oral dosing with minimal accumulation. Delafloxacin was well tolerated throughout both studies, with gastrointestinal effects observed at the higher doses (≥1200 mg)