GPS2 nuclear localization and TBL1-mediated stabilization are important in regulating nuclear encoded mitochondrial gene expression

G-protein pathway suppressor 2 (GPS2) is a 36kD protein involved in a number of regulatory functions in key metabolic organs. First discovered as a suppressor of the RAS- and MAPK- signaling pathways, GPS2 is subsequently identified as part of the NCoR/SMRT corepressor complex that play an important regulatory role in gene transcription, and GPS2 is also involved in meiotic recombination in the nucleus. Recently, we identified a non-transcriptional role of GPS2 as an inhibitor of the pro-inflammatory JNK pathway activation in response to tumor necrosis factor alpha (TNF-a;) in the cytosol. This suggests that GPS2 function may be dependent on its cellular localization. However, an understanding of how GPS2 differentially target cellular compartments is still lacking. In this study, we show that a tightly controlled balance between GPS2 protein stabilization and degradation regulates the function of nuclear GPS2. Our results reveal that methylation by arginine methyltransferase PRMT6 and interaction with exchange factor TBL1 cooperate to protect GPS2 from Siah2-dependent proteasomal degradation, thus promoting GPS2 nuclear localization. In addition, our results link GPS2 protein instability to decreased nuclear-encoded mitochondrial gene expression, suggesting that GPS2 may play an important role in regulating mitochondrial oxidative capacity, whose imbalance has been linked to chronic inflammation and insulin resistance. In conclusion, our findings illustrate post-transcriptional modification is important in the regulation of GPS2 cellular function. Understanding such molecular regulation of GPS2 is critical in furthering future efforts to investigate its roles in cellular homeostasis and inflammatory responses

Value Premium In The Chinese Stock Market：Free Lunch Or Paid Lunch?

In this paper we examine the time-series predictability of the book-to-market (B/M) ratio for annual and monthly portfolio returns in the Chinese stock market.  We find that value premiums exist throughout our sample period of 1998 to 2008. However, the predictability of B/M appears to be unrelated with financial distress risk. In fact, value stocks are less risky than growth stocks in terms of return volatility and estimated financial distress risk. Further, our results suggest that the factor VMG, which is directly related to value premium, is not a pervasive risk measure compared to market factor and SMB. While the size effect seems to be closely related to distress risk, both size and B/M factors do not appear to be driven by financial distress risk

The Evaluation on Home Improvement Website’s Efficiency Based on SBM-DEA

We built the efficiency evaluation index system of home improvement website’s inputs and outputs. The SBM - DEA model is applied to evaluate the efficiency of 30 home improvement websites and the stability of relatively effective websites. Finally, we put forward some specific website optimization suggestions with the results. The purposes of this paper are to study the efficiency of home improvement websites and provide webmasters with optimization suggestions under limited input resources

Research on Influence Factors of Information Technology Enterprise\u27s Operating Performance

This paper uses grounded theory to interview a listed information technology company in Guangzhou, and establishes the influence factors model of information technology enterprise\u27s operating performance. The model concludes 17 key factors, including national policy, regional environment, market situation, strategy, execution, corporate values and leadership. The purpose of research is to help listed information technology enterprises improve their operating performance

Sperm trajectories form chiral ribbons.

We report the discovery of an entirely new three-dimensional (3D) swimming pattern observed in human and horse sperms. This motion is in the form of 'chiral ribbons', where the planar swing of the sperm head occurs on an osculating plane creating in some cases a helical ribbon and in some others a twisted ribbon. The latter, i.e., the twisted ribbon trajectory, also defines a minimal surface, exhibiting zero mean curvature for all the points on its surface. These chiral ribbon swimming patterns cannot be represented or understood by already known patterns of sperms or other micro-swimmers. The discovery of these unique patterns is enabled by holographic on-chip imaging of >33,700 sperm trajectories at >90-140 frames/sec, which revealed that only ~1.7% of human sperms exhibit chiral ribbons, whereas it increases to ~27.3% for horse sperms. These results might shed more light onto the statistics and biophysics of various micro-swimmers' 3D motion

Immune Checkpoint Inhibitors in Hodgkin Lymphoma and Non-Hodgkin Lymphoma

Lymphoma, which mainly includes Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL), is the most common hematological malignance of the lymphoid tissues with significantly heterogeneous characteristics. Tumor immune disequilibrium is involved in tumor development and progression, evading tumor immunosurveillance and suppressing anti-tumor immune responses. The tumor microenvironment (TME) is a complex network that comprises stromal cells and extracellular matrix, playing important roles in the pathogenesis, progression, and drug resistance of lymphoma. Therefore, a promising therapeutic strategy for lymphoma is by targeting the TME to stimulate anticancer immunity either by enhancing the release of immunostimulatory molecules or by mediating immune cell populations. Notably, immune checkpoint therapy (ICT) can provide durable clinical responses and improve overall survival in HL and NHL. However, different subsets of patients with lymphoma have different responses to ICT. Thus, significant challenges remain, including understanding pathways of resistance, optimizing patient selection, improving the management of immune-related adverse events, and identifying rational therapeutic combinations. This will allow a better understanding of the potential applications of ICT in lymphoma, guiding decisions to develop novel combination strategies with maximum efficacy and minimal toxicities for patients

Real-time Data Flow Control for CBM-TOF Super Module Quality Evaluation

Super module assembled with MRPC detectors is the component unit of TOF (Time of Flight) system for the Compressed Baryonic Matter (CBM) experiment. Quality of super modules needs to be evaluated before it is applied in CBM-TOF. Time signals exported from super module are digitalized at TDC (Time to Digital Converter) station. Data rate is up to 6 Gbps at each TDC station, which brings a tremendous pressure for data transmission in real time. In this paper, a real-time data flow control method is designed. In this control method, data flow is divided into 3 types: scientific data flow, status data flow and control data flow. In scientific data flow, data of each TDC station is divided into 4 sub-flows, and then is read out by a parallel and hierarchical network, which consists of multiple readout mother boards and daughter boards groups. In status data flow, status data is aggregated into a specific readout mother board. Then it is uploaded to DAQ via readout daughter board. In control data flow, control data is downloaded to all circuit modules in the opposite direction of status data flow. Preliminary test result indicated data of STS was correctly transmitted to DAQ with no error and three type data flows were control orderly in real time. This data flow control method can meet the quality evaluation requirement of supper module in CBM-TOF

Effect of hip fracture on prognosis of acute cerebral infarction

OBJECTIVES: Hip fractures are a worldwide public health problem. The incidence of hip fracture is high among the elderly, and it is an important cause of death and disability in this population. This observational study aimed to investigate the effect of acute hip fracture on the recovery of neurological function and the prognosis of patients with acute cerebral infarction, as well as whether surgical treatment of combined acute fracture can improve the prognosis of patients. METHODS: Thirty patients with acute cerebral infarction combined with acute hip fracture, who were hospitalized in two hospitals between January 1, 2013 and December 31, 2019, were included. The patients did not undergo surgical treatment. The control group included patients with common acute cerebral infarction without hip fracture admitted in the same period. The neurological function recovery, hospitalization period, half a year recovery rate, incidence of complications, and one-year mortality rate between the two groups were compared. Eleven patients with acute cerebral infarction combined with hip fracture, who underwent surgical treatment, were selected and compared with those in the non-surgery group. RESULTS: Compared with patients with common acute cerebral infarction, the National Institutes of Health Stroke Scale score of those with acute cerebral infarction combined with hip fracture was higher (7.2±5.4 vs. 5.6%±4.3, p=0.034), the hospitalization period was prolonged (16.1±8.9% vs. 12.2±5.3, p=0.041), and the half a year recovery rate was lower (26.7% vs. 53.3%, p=0.016). Additionally, the incidence of pulmonary infection and lower extremity deep vein thrombosis was increased (30% vs. 11.7%, p=0.03; 6.7% vs. 0, p=0.043). The one-year mortality rate of patients with hip fracture was higher than that of patients with common cerebral infarction (23.3% vs. 6.7%, p=0.027). Compared with the non-surgical group, the good recovery rate after half a year of surgical treatment of the group with cerebral infarction and acute hip fracture had an increasing trend, while the hospitalization cycle, incidence of complications, and one-year mortality rate were all decreased, although this was not statistically significant. CONCLUSIONS: Acute cerebral infarction combined with hip fracture leads to worse neurological recovery, prolonged hospitalization period, increased complications, decreased patient prognosis, and increased one-year mortality. Surgical treatment improves the prognosis of patients with acute cerebral infarction. These findings may provide insights into the management of acute cerebral infarction