5,385 research outputs found
Effects of Kinks on DNA Elasticity
We study the elastic response of a worm-like polymer chain with reversible
kink-like structural defects. This is a generic model for (a) the
double-stranded DNA with sharp bends induced by binding of certain proteins,
and (b) effects of trans-gauche rotations in the backbone of the
single-stranded DNA. The problem is solved both analytically and numerically by
generalizing the well-known analogy to the Quantum Rotator. In the small
stretching force regime, we find that the persistence length is renormalized
due to the presence of the kinks. In the opposite regime, the response to the
strong stretching is determined solely by the bare persistence length with
exponential corrections due to the ``ideal gas of kinks''. This high-force
behavior changes significantly in the limit of high bending rigidity of the
chain. In that case, the leading corrections to the mechanical response are
likely to be due to the formation of multi-kink structures, such as kink pairs.Comment: v1: 16 pages, 7 figures, LaTeX; submitted to Physical Review E; v2: a
new subsection on soft kinks added to section Theory, sections Introduction
and Conclusions expanded, references added, other minor changes; v3: a
reference adde
Toeplitz Inverse Covariance-Based Clustering of Multivariate Time Series Data
Subsequence clustering of multivariate time series is a useful tool for
discovering repeated patterns in temporal data. Once these patterns have been
discovered, seemingly complicated datasets can be interpreted as a temporal
sequence of only a small number of states, or clusters. For example, raw sensor
data from a fitness-tracking application can be expressed as a timeline of a
select few actions (i.e., walking, sitting, running). However, discovering
these patterns is challenging because it requires simultaneous segmentation and
clustering of the time series. Furthermore, interpreting the resulting clusters
is difficult, especially when the data is high-dimensional. Here we propose a
new method of model-based clustering, which we call Toeplitz Inverse
Covariance-based Clustering (TICC). Each cluster in the TICC method is defined
by a correlation network, or Markov random field (MRF), characterizing the
interdependencies between different observations in a typical subsequence of
that cluster. Based on this graphical representation, TICC simultaneously
segments and clusters the time series data. We solve the TICC problem through
alternating minimization, using a variation of the expectation maximization
(EM) algorithm. We derive closed-form solutions to efficiently solve the two
resulting subproblems in a scalable way, through dynamic programming and the
alternating direction method of multipliers (ADMM), respectively. We validate
our approach by comparing TICC to several state-of-the-art baselines in a
series of synthetic experiments, and we then demonstrate on an automobile
sensor dataset how TICC can be used to learn interpretable clusters in
real-world scenarios.Comment: This revised version fixes two small typos in the published versio
Network Inference via the Time-Varying Graphical Lasso
Many important problems can be modeled as a system of interconnected
entities, where each entity is recording time-dependent observations or
measurements. In order to spot trends, detect anomalies, and interpret the
temporal dynamics of such data, it is essential to understand the relationships
between the different entities and how these relationships evolve over time. In
this paper, we introduce the time-varying graphical lasso (TVGL), a method of
inferring time-varying networks from raw time series data. We cast the problem
in terms of estimating a sparse time-varying inverse covariance matrix, which
reveals a dynamic network of interdependencies between the entities. Since
dynamic network inference is a computationally expensive task, we derive a
scalable message-passing algorithm based on the Alternating Direction Method of
Multipliers (ADMM) to solve this problem in an efficient way. We also discuss
several extensions, including a streaming algorithm to update the model and
incorporate new observations in real time. Finally, we evaluate our TVGL
algorithm on both real and synthetic datasets, obtaining interpretable results
and outperforming state-of-the-art baselines in terms of both accuracy and
scalability
A coherent phonon-induced hidden quadrupolar ordered state in CaRuO
Ultrafast laser excitation provides a means to transiently realize long-range
ordered electronic states of matter that are hidden in thermal equilibrium.
Recently, this approach has unveiled a variety of thermally inaccessible
ordered states in strongly correlated materials, including charge density wave,
ferroelectric, magnetic, and intertwined charge-orbital ordered states.
However, more exotic hidden states exhibiting higher multipolar ordering remain
elusive owing to the challenge of directly manipulating and detecting them with
light. Here we demonstrate a method to induce a dynamical transition from a
thermally allowed to a thermally forbidden spin-orbit entangled quadrupolar
ordered state in CaRuO by coherently exciting a phonon that is strongly
coupled to the order parameter. Combining probe photon energy-resolved coherent
phonon spectroscopy measurements with model Hamiltonian calculations, we show
that the dynamical transition is manifested through anomalies in the
temperature, pump excitation fluence, and probe photon energy dependence of the
strongly coupled phonon. With this procedure, we introduce a general pathway to
uncover hidden multipolar ordered states and to control their re-orientation on
ultrashort timescales.Comment: 8 pages, 4 figure
Divergence and Shannon information in genomes
Shannon information (SI) and its special case, divergence, are defined for a
DNA sequence in terms of probabilities of chemical words in the sequence and
are computed for a set of complete genomes highly diverse in length and
composition. We find the following: SI (but not divergence) is inversely
proportional to sequence length for a random sequence but is length-independent
for genomes; the genomic SI is always greater and, for shorter words and longer
sequences, hundreds to thousands times greater than the SI in a random sequence
whose length and composition match those of the genome; genomic SIs appear to
have word-length dependent universal values. The universality is inferred to be
an evolution footprint of a universal mode for genome growth.Comment: 4 pages, 3 tables, 2 figure
A Coherent Study of Emission Lines from Broad-Band Photometry: Specific Star-Formation Rates and [OIII]/H{\beta} Ratio at 3 < z < 6
We measure the H{\alpha} and [OIII] emission line properties as well as
specific star-formation rates (sSFR) of spectroscopically confirmed 3<z<6
galaxies in COSMOS from their observed colors vs. redshift evolution. Our model
describes consistently the ensemble of galaxies including intrinsic properties
(age, metallicity, star-formation history), dust-attenuation, and optical
emission lines. We forward-model the measured H{\alpha} equivalent-widths (EW)
to obtain the sSFR out to z~6 without stellar mass fitting. We find a strongly
increasing rest-frame H{\alpha} EW that is flattening off above z~2.5 with
average EWs of 300-600A at z~6. The sSFR is increasing proportional to
(1+z)^2.4 at z<2.2 and (1+z)^1.5 at higher redshifts, indicative of a fast mass
build-up in high-z galaxies within e-folding times of 100-200Myr at z~6. The
redshift evolution at z>3 cannot be fully explained in a picture of cold
accretion driven growth. We find a progressively increasing
[OIII]{\lambda}5007/H{\beta} ratio out to z~6, consistent with the ratios in
local galaxies selected by increasing H{\alpha} EW (i.e., sSFR). This
demonstrates the potential of using "local high-z analogs" to investigate the
spectroscopic properties and relations of galaxies in the re-ionization epoch.Comment: 18 pages, 11 figures, 3 table
Modeling secondary level of HIV contact tracing: its impact on HIV intervention in Cuba
<p>Abstract</p> <p>Background</p> <p>Universal HIV testing/treatment program has currently been suggested and debated as a useful strategy for elimination of HIV epidemic in Africa, although not without practical issues regarding the costs and feasibility of a fully implemented program.</p> <p>Methods</p> <p>A mathematical model is proposed which considers two levels of detection of HIV-infectives through contact tracing of known infectives in addition to detections through other means such as random screening. Simulations based on Cuban contact tracing data were performed to ascertain the potential impact of the different levels of contact tracing.</p> <p>Results</p> <p>Simulation studies illustrate that: (1) contact tracing is an important intervention measure which, while less effective than random screening, is perhaps less costly and hence ideal for large-scale intervention programs in developing countries with less resources; (2) the secondary level of contact tracing could significantly change the basic disease transmission dynamics, depending on the parameter values; (3) the prevalence of the epidemic at the time of implementation of contact tracing program might be a crucial factor in determining whether the measure will be effective in preventing disease infections and its eventual eradication.</p> <p>Conclusions</p> <p>Our results indicate that contact tracing for detection of HIV infectives could be suitably used to remedy inadequacies in a universal HIV testing program when designing timely and effective intervention measures.</p
Signatures of Ultrafast Reversal of Excitonic Order in Ta₂NiSe₅
In the presence of electron-phonon coupling, an excitonic insulator harbors two degenerate ground states described by an Ising-type order parameter. Starting from a microscopic Hamiltonian, we derive the equations of motion for the Ising order parameter in the phonon coupled excitonic insulator Ta₂NiSe₅ and show that it can be controllably reversed on ultrashort timescales using appropriate laser pulse sequences. Using a combination of theory and time-resolved optical reflectivity measurements, we report evidence of such order parameter reversal in Ta₂NiSe₅ based on the anomalous behavior of its coherently excited order-parameter-coupled phonons. Our Letter expands the field of ultrafast order parameter control beyond spin and charge ordered materials
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