The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

To access publisher's full text version of this article click on the hyperlink belowY Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private testing companies to parents using in vitro fertilisation as being useful in selecting the embryos that carry the least risk of disease in later life. It appears that at least one child has been born after such a procedure. But the utility of a PRS in this respect is severely limited, and to date, no clinical research has been performed to assess its diagnostic effectiveness in embryos. Patients need to be properly informed on the limitations of this use of PRSs, and a societal debate, focused on what would be considered acceptable with regard to the selection of individual traits, should take place before any further implementation of the technique in this population.World Cancer Research Fund (WCRF UK) World Cancer Research Fund International (WCRF) European Commission Ministry of Science and Higher Education of Russian Federation French National Research Agency (ANR) European Commission European Union through the "Fonds europeen de developpement regional" (FEDER) Conseil Regional des Hauts-de-France" (Hauts-de-France Regional Council) "Metropole Europeenne de Lille" (MEL, European Metropolis of Lille