The Effect of Web Reinforcement on the Shear Capacity of Brick Aggregate Concrete Beams

Shear capacity of reinforced brick aggregate concrete beams without any web reinforcement and with varying ratio of web reinforcement was studied in this investigation. Deflections of beams and cracks during the progress of loading were recorded. Brick aggregate concrete beams with web reinforcement and two layers of tensile reinforcement were found to have increased cracking shear stress by a considerable amount. Equations for cracking and ultimate shear stresses were suggested within the scope of this study. The experimental values of ultimate shear strength of beams were compared with the values obtained by equations proposed by ACI and other researchers. The equations proposed herein were found to represent the test results better than those of other researchers while remaining on the conservative side. It is hoped that the equations developed herein will provide a rational and basic point of departure from the prevailing concept and will help towards the formulation of a suitable code to provide web reinforcement for brick aggregate concrete beams

Genetic diversity analysis of some Bangladeshi aromatic rice (Oryza sativa L.) using simple sequence repeat markers (SSRM)

In order to germplasm management, conservation, parental identification and proper utilization of aromatic rice germplasm of Bangladesh genetic diversity assessment and molecular characterization is necessary. We used ten microsatellite markers across twenty aromatic rice landraces along with four improved varieties to discriminate and characterize among them. The number of alleles per locus ranged from 2 to 8, with an average of 4.30 alleles across 10 loci. A total of 43 polymorphic alleles were detected. The values of Polymorphic information content (PIC) ranged from 0.217 to 0.835 (average 0.495) which indicate high genetic diversity among the studied aromatic rice genotypes. It was concluded by the PIC value of RM5339 that it might be the finest marker for diversity estimation and characterize of these aromatic rice genotypes, followed by RM334, RM414 and RM28502 markers. The UPGMA cluster dendrogram constructed in this study identified seven clusters with a correlation coefficient 0.874. Molecular characterization of aromatic rice landraces of Bangladesh exhibited large variations among the genotypes. Five rice genotypes namely BRRI dhan38, BRRI dhan50, Bashmoti safed, Malaysira, Khas-kani showed highest genetic dissimilarity among the studied rice genotypes. The findings of this study would be useful for background selection in backcross breeding programs for aromatic rice improvement as well as identification of genetically distant and genetically close accessions for maintenance and conservation

Introduction of Medical Imaging Modalities

The diagnosis and treatment of various diseases had been expedited with the help of medical imaging. Different medical imaging modalities, including X-ray, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Nuclear Imaging, Ultrasound, Electrical Impedance Tomography (EIT), and Emerging Technologies for in vivo imaging modalities is presented in this chapter, in addition to these modalities, some advanced techniques such as contrast-enhanced MRI, MR approaches for osteoarthritis, Cardiovascular Imaging, and Medical Imaging data mining and search. Despite its important role and potential effectiveness as a diagnostic tool, reading and interpreting medical images by radiologists is often tedious and difficult due to the large heterogeneity of diseases and the limitation of image quality or resolution. Besides the introduction and discussion of the basic principles, typical clinical applications, advantages, and limitations of each modality used in current clinical practice, this chapter also highlights the importance of emerging technologies in medical imaging and the role of data mining and search aiming to support translational clinical research, improve patient care, and increase the efficiency of the healthcare system.Comment: 19 pages, 7 figures, 1 table; Acceptance of the chapter for the Springer book "Data-driven approaches to medical imaging

A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship

Cancer is a disorder that rigorously affects the human population worldwide. There is a steady demand for new remedies to both treat and prevent this life-threatening sickness due to toxicities, drug resistance and therapeutic failures in current conventional therapies. Researchers around the world are drawing their attention towards compounds of natural origin. For decades, human beings have been using the flora of the world as a source of cancer chemotherapeutic agents. Currently, clinically approved anticancer compounds are vincristine, vinblastine, taxanes, and podophyllotoxin, all of which come from natural sources. With the triumph of these compounds that have been developed into staple drug products for most cancer therapies, new technologies are now appearing to search for novel biomolecules with anticancer activities. Ellipticine, camptothecin, combretastatin, curcumin, homoharringtonine and others are plant derived bioactive phytocompounds with potential anticancer properties. Researchers have improved the field further through the use of advanced analytical chemistry and computational tools of analysis. The investigation of new strategies for administration such as nanotechnology may enable the development of the phytocompounds as drug products. These technologies have enhanced the anticancer potential of plant-derived drugs with the aim of site-directed drug delivery, enhanced bioavailability, and reduced toxicity. This review discusses mechanistic insights into anticancer compounds of natural origins and their structural activity relationships that make them targets for anticancer treatments

Mental health of young people amidst COVID-19 pandemic in Bangladesh

Background: The psychological burden of the coronavirus disease 2019 (COVID-19) outbreak and lockdown strategy among young people not diagnosed with COVID-19 in the general population remains unknown and often have been overlooked. The objective of the study was to assess the prevalence and predictors of anxiety, depression and stress among young people diagnosed with COVID-19 of Bangladesh amidst the pandemic. Methods: A cross-sectional online survey was conducted from 1 May to 30 May 2020 using an online Google form-based questionnaire posted on Facebook. A snowball sampling approach was used for data collection. A total of 974 self-declared healthy individuals not diagnosed with COVID-19 participated here. Anxiety, depression and stress were measured using Bangla validated Generalized Anxiety Disorder Scale-7 (GAD-7), Patient Health Questionnaire (PHQ-9) scale, and Perceived Stress Scale (PSS), respectively. Statistical software SPSS 20 was used for analysis. Result: Average age of the population was 25.86 ± 6.26 (SD) years with nearly half (48.6%) of them being young people (15 to ≤24 years). Most of the participants were male (76.3%). The overall prevalence of anxiety, depression and stress was found to be 64.1%, 73.3% and 69.4%, respectively. Young people had significantly higher proportion of anxiety (67.2% vs 61.1%), and depression (78.2% vs 68.7%) compared to adults (p = 0.045 and p < 0.001, respectively). However, most of the participants had mild depression (30.3%), minimal anxiety (31.4%), and moderate stress (67.5%), and severity of depression and anxiety was higher in the young participants. The mean GAD-7, PHQ-9 and PSS scores were 7.57 ± 5.61, 9.19 ± 6.15 and 16.02 ± 5.55 (SD), respectively. On multivariable logistic analysis, unemployment (Adjusted Odds Ratio [AOR] 3.642; Confidence Interval [CI]: 1.005–13.200; p < 0.05) was the single most important predictor of depression. For stress, unemployment (AOR 1.399; CI: 1.055–1.855), and female sex (AOR 1.638; CI: 1.158–2.317) were significant predictors. Conclusion: Anxiety, depression and stress were highly prevalent among young people (≤24 years) not diagnosed with COVID-19 in Bangladesh amidst the pandemic. Unemployment is the most common underlying determinant. Authorities should address the issue on a priority basis

Feasibility and acceptability of telepathology system among the rural communities of Bangladesh: A pilot study

Context: Telepathology is a promising tool for remote communities to receive pathology services where professional diagnosis services are inadequate. Aims: We aimed to clarify how effective telepathology was when compared with conventional pathology service among rural communities of Bangladesh. Methods and Materials: We conducted a cross-sectional study in suburban and rural areas of Bangladesh between June and August 2020. We enrolled 117 participants who received both telepathology services from Thakurgaon Eye Hospital and conventional pathology service experience. The participant's satisfaction with the accessibility and perceptions were statistically compared. In addition, we summarized descriptive statistics using the frequencies and percentages of participants' responses. Statistical Analysis Used: Wilcoxon's Signed-rank test using SPSS statistic software version 25.00. Results: Among the study participants, service cost, travel cost, travel time, waiting time, and travel distance were significantly higher for conventional pathology than telepathology (P < 0.001). The majority of participants (94%) were satisfied with the telepathology experience; however, one out of 117 participants was dissatisfied with this service when their travel distance was far away (≥50 km). Among the participants, 91.5% thought that telepathology service was effective for their treatment, and 98.3% wanted to continue this service in their community. On an average, participants saved 58% (95% CI, 53.4–61.5) of cost using telepathology rather than conventional pathology service. Conclusions: Remote under-resourced communities received professional pathology services with less time-consuming and significantly lower costs using the telepathology approach. Where pathology services are absent/insufficient, telepathology is efficacious for primary diagnosis, screening, and referral through professional pathologists for the satisfactory treatment of unreached communities