Peranan Badan Permusyawaratan Desa dalam Pembangunan Masyarakat di Desa Tateli Induk Kecamatan Mandolang Kabupaten Minahasa

Reformation era which aims to holdcorrection or alteration, the arrangement and arrangement back variousentertainments the social life of, nation and the country that better suit,conformable, and in line with the aim of the state as mandated in the openingconstitution of the Republic of Indonesia 1945 continuously tries to doproperly. Efforts to improve the developmentof rural areas in regional autonomy era now this is an important step andstrategic that need in observed in mobilise and diligently. For that thegovernment has determined to improve our motion village development in ruralareas. Hence the effort of development and empowerment of the village is animportant step to be done and improved by careful and effective. Through BPD the government hopes,invite and offer the opportunity as possible to the public to participate.Consultative board village as the receptacle of channeling collectors and theaspirations of the people who help the government village in performing andevelopment and have an important role because the village development veryuseful for all the village community. Community Tateli village there areseveral elements that can be used to run a course of development. Elements suchis that the community village Tateli solidarity having a strong, bothvertically and horizontally. Vertical in the sense of loyalty the communitywith the village administration and horizontally in the meaning of thesolidarity that binds the residents

Complex High-Content Phenotypic Screening

There has been a renewed interest in cell-based phenotypic screening in drug discovery with the goal of improving the success and decreasing the clinical failure rate of new therapeutics. This has increasingly led to the development of biomimetic cellular models that more faithfully replicate human disease biology. Human tumour models have advanced to include relevant cell types such as primary patient tumour cells and grown using organotypic and 3D methods. Tissue organoids, which are 3D organ buds displaying realistic microanatomy, are becoming more commonly used in drug discovery to advance in vitro assays which predict drug toxicity and pharmacokinetics. Emerging technologies and cell culture methods are constantly improving the quality of tissue modelling that can be employed during primary phenotypic screening, and this has resulted in the identification of more efficacious and patient-relevant therapeutics

KAJIAN YURIDIS PROSES LEGALITAS PENJUALAN CAP TIKUS DI MINAHASA SELATAN

Tujuan penelitian ini untuk mengetahui bagaimana proses legalitas penjualan dari produk cap tikus 1978 dan apakah penjualan produk cap tikus 1978 legal di luar Indonesia, di mana dengan metode penelitian normatif disimpulkan bahwa: 1. Proses legalitas penjualan dari produk cap tikus 1978 dimulai dengan pemasukkan berkas kepada pemerintah kabupaten minahasa selatan dan pemerintah pusat. Setelah izin dari pemerintah daerah dan pemerintah pusat keluar maka perlu izin dari pihak BPOM untuk menjamin bahwa produk cap tikus 1978 ini layak untuk di konsumsi. Selain izin dari pihak BPOM diperlukan juga izin dari pihak bea cukai hal ini agar produk cap tikus 1978 dapat dipasarkan atau diperjual-belikan di seluruh wilayah Indonesia. 2. Produk cap tikus 1978 legal untuk dijual di luar negara Indonesia hal ini karena produk cap tikus 1978 sudah legal menurut aturan hukum dan undang-undang yang berlaku di negara asalnya Indonesia. Dan untuk penjualan kembali produk cap tikus 1978 bisa langsung di ekspor ke negara tujuan dengan melihat aturan hukum dan undang-undang yang berlaku di negara tujuan. Namun sebelumnya eksportir juga harus melengkapi berkas yang berisikan syarat-syarat untuk mengekspor minuman beralkohol.Kata kunci: cap tukus; legalitas penjualan

Analytical Chemistry in Industrial Food Research

Because of the complexity of food matrices, analytical chemistry has a key role to play in the elucidation of food composition, food stability and its behaviour during processing. In this paper, the application of various analytical techniques (e.g., near IR spectroscopy, electronic nose technology, nuclear magnetic resonance and mass spectrometry) are discussed

Fostering Community and Civic Engagement in Low Income Multicultural Schools through Transformative Leadership

In this study, we examine how transformative leadership enables students from a low-income and multicultural neighbourhood to learn about democracy, re-sponsible citizenship, and community engagement at school. As part of a graduate seminar on critical pedagogy and cultural studies in education, in-depth group interviews were conducted with students in three different schools. The objective of the study was to give voice to these students and to better un-derstand how and why they had decided to become involved in a democracy-oriented school project. The paper focuses on the results obtained in one of the schools, located in a low-income multicultural neighbourhood, where the students’ authentic process of community and civic engagement was facili-tated by the transformative leadership of the principal, the assistant principals, and the teacher leaders

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

There is increasing evidence that ubiquitination of receptors provides an important endosomal sorting signal. Here we report that mammalian class E vacuolar protein-sorting (vps) proteins recognize ubiquitin. Both tumor susceptibility gene 101 (TSG101)/human VPS (hVPS)28 and hepatocyte growth factor receptor substrate (Hrs) cytosolic complexes bind ubiquitin-agarose. TSG101 and hVPS28 are localized to endosomes that contain internalized EGF receptor and label strongly for ubiquitinated proteins. Microinjection of anti-hVPS28 specifically retards EGF degradation and leads to endosomal accumulation of ubiquitin–protein conjugates. Likewise, depletion of TSG101 impairs EGF trafficking and causes dramatic relocalization of ubiquitin to endocytic compartments. Similar defects are found in cells overexpressing Hrs, further emphasizing the links between class E protein function, receptor trafficking, and endosomal ubiquitination