Tonal prisms: iterated quantization in chromatic tonality and Ravel's 'Ondine'

The mathematics of second-order maximal evenness has far-reaching potential for application in music analysis. One of its assets is its foundation in an inherently continuous conception of pitch, a feature it shares with voice-leading geometries. This paper reformulates second-order maximal evenness as iterated quantization in voice-leading spaces, discusses the implications of viewing diatonic triads as second-order maximally even sets for the understanding of nineteenth-century modulatory schemes, and applies a second-order maximally even derivation of acoustic collections in an in-depth analysis of Ravel's ‘Ondine’. In the interaction between these two very different applications, the paper generalizes the concepts and analytical methods associated with iterated quantization and also pursues a broader argument about the mutual dependence of mathematical music theory and music analysis.Accepted manuscrip

Study of cryogenic fluid mixing techniques. Volume 1 - Large-scale experimental mixing investigations and liquid-oxygen mixer design Final report

Large-scale experimental liquid hydrogen mixing and liquid oxygen mixer desig

The momentum spectrum of nuclear active particles in the cosmic radiation

This thesis describes studies of nuclear active particles (NAPs) in the cosmic radiation over the momentum range 1-30 GeV/c. Both unaccompanied particles and NAPs in extensive air showers (EAS) are studied near sea level at Durham using an air-gap magnet spectrograph in conjunction with a neutron monitor. Details are given of the design of the spectrograph, neutron monitor and associated equipment as used for measurements on unaccompanied NAPs (Chapter 2), and the techniques used for derivation of the momentum spectra from the basic data are described in Chapter 3. The results, in the form of momentum spectra of unaccompanied protons and negative pions, and the limited analysis of NAPs in EAS are presented in Chapter 4 where they are compared with the results of other workers. Measurements of the momentum of NAPs in EAS were found to be difficult and the data are mainly concerned with the response of the neutron monitor to EAS. A model of the propagation of cosmic rays through the atmosphere, which was mainly intended for predictions of the properties of large EAS, is described and used to predict the momentum spectra of unaccompanied particles at sea level. The results of this prediction are compared with the experimental data (Chapter 5) and the results of other model predictions (Chapter 6). It is shown that no single model, when combined with a reasonable spectrum of primary cosmic rays, can adequately explain all the data on unaccompanied particles at sea level. It is also shown that the spectra of high energy protons and pions are likely to be the sea level measurements which are most sensitive to the form of the primary cosmic ray spectrum

Asbestos-laden soil: a case study analysis of Swift Creek

In the rural area of Whatcom County, Washington there is a naturally occurring asbestos site on the west side of Sumas Mountain. The asbestos laden-soil became airborne after a landslide occurred on the mountain causing asbestos-laden sediment to become loose and every year, one-hundred thousand cubic yards flows into the nearby Swift Creek. There are many stakeholders who are involved in developing mitigation policies. These include agency officials and elected representatives from a variety of levels of government and private property owners. This case study expands on the relationship between less pressing environmental issues and the types conditions that must be in place in order for solutions to be created by regulatory bodies. The case of Swift Creek is an example of a relatively rare environmental event that has huge potential for causing serious contamination for many people. Though this case is unique, these types of definitional debates are not

Case study of the automation options and decisions made in implementing a high-throughput cell based screen using the FLIPR™

This case study examines the automation and process change options available to emerging discovery/development stage pharmaceutical companies when considering implementing sophisticated high-throughput screens. Generally there are both financial and personnel constraints that have to be addressed when implementing state-of-the-art screening technology in smaller companies which generally are not as significant as in large pharmaceutical companies. When NPS Pharmaceuticals considered installing a Molecular Devices FLIPR™ for high-throughput cell based screening it became clear that, to make the best decision, the whole screening process at NPS Pharmaceuticals from screen development and validation, tissue culture, compound distribution, data handling and screening had to be re-examined to see what automation options were possible and which, if any, made sense to implement. Large scale automated systems were not considered due to their cost and the lack of in-house engineering infrastructure to support such systems. The current trend towards workstation based laboratory automation suggested that a minimalist approach to laboratory automation, coupled with improved understanding of the physical process of screening, would yield the best approach. Better understanding of the work flow within the Biomolecular Screening team enabled the group to optimize the process and decide what support equipment was needed. To install the FLIPR™, train users, set up the tissue culture protocols for cell supply, establish high-throughput screening database protocols, integrate compound distribution and re-supply and validate the pharmacology on four cell based screens took the team 3 months. The integration of the screening team at the primary, secondary and tertiary screening stages of the target discovery project teams at NPS has enabled us to incorporate minimal automation into the Biomolecular Screening Group whilst retaining an enriching work environment. This is reflected in our current consistent throughput of 64 96-well microplates per day on the FLIPR™, a figure that is comparable with that achieved within most major pharmaceutical companies. This case study suggests that process optimization coupled with modern stand alone automated workstations can achieve significant throughput in a resource constrained environment. Significantly greater throughput could be achieved by coupling the process improvement techniques described above with 384-well microplate technology

Look Again: Effects of Brain Images and Mind-Brain Dualism on Lay Evaluations of Research

Brain scans have frequently been credited with uniquely seductive and persuasive qualities, leading to claims that fMRI research receives a disproportionate share of public attention and funding. It has been suggested that functional brain images are fascinating because they contradict dualist beliefs regarding the relationship between the body and the mind. Although previous research has indicated that brain images can increase judgments of an articleʼs scientific reasoning, the hypotheses that brain scans make research appear more interesting, surprising, or worthy of funding have not been tested. Neither has the relation between the allure of brain imaging and dualism. In the following three studies, laypersons rated both fictional research descriptions and real science news articles accompanied by brain scans, bar charts, or photographs. Across 988 participants, we found little evidence of neuroimagingʼs seductive allure or of its relation to self-professed dualistic beliefs. These results, taken together with other recent null findings, suggest that brain images are less powerful than has been argued