Multi-scale friction modeling for manufacturing processes: The boundary layer regime

This paper presents a multi-scale friction model for largescale forming simulations. A friction framework has been developed including the effect of surface changes due to normal loading and straining the underlying bulk material. A fast and efficient translation from micro to macro modeling, based on stochastic methods, is incorporated to reduce the computational effort. Adhesion and ploughing effects have been accounted for to characterize friction conditions on the micro scale. A discrete model has been adopted which accounts for the formation of contact patches ploughing through the contacting material. To simulate metal forming processes a coupling has been made with an implicit Finite Element code. Simulations on a typical metal formed product shows a distribution of friction values. The modest increase in simulation time, compared to a standard Coulomb-based FE simulation, proves the numerical feasibility of the proposed method

Real-life effectiveness of once-daily calcipotriol and betamethasone dipropionate gel vs. ointment formulations in psoriasis vulgaris: final analysis of the 52-week PRO-long study

Background: Topical therapies are the mainstay of treatment for psoriasis vulgaris. The fixed combination of calcipotriol (Cal) 50 mu g/g plus betamethasone 0.5 mg/g (as dipropionate; BD) is a first-line topical treatment and available as a gel or ointment. The use of these fixed combination products was compared in PRO-long, a long-term noninterventional study, for which interim results (4 and 12 weeks) have previously been reported. Objective: To describe and compare patients' perspectives on the fixed combination gel and ointment formulations; to include efficacy, adherence behaviour, treatment satisfaction and health-related quality of life (HRQoL) aspects during long-term real-life psoriasis management. Methods: PRO-long was a multicentre, prospective, observational, 52-week study of patients prescribed fixed combination Cal/BD gel or ointment in clinical practice. For final analysis the following were assessed at weeks 24, 36 and 52: differences in the proportion of patients with 'mild'/'very mild' disease according to patient's global assessment of disease severity, adherence behaviour, treatment satisfaction (nine-item treatment satisfaction questionnaire for medication) and HRQoL (Skindex-29). Results: Patients (n = 328) were prescribed once-daily Cal/BD gel (n = 152) or ointment (n = 176). At week 52, a higher proportion of patients reported that the severity of their psoriasis was 'mild'/'very mild' vs. baseline (gel: 60.2 vs. 47.1%; ointment: 58.8 vs. 42.4%), with greater treatment satisfaction reported in patients using gel vs. those using ointment. A higher proportion of patients found the gel 'easy' to use compared with the ointment (66.7 vs. 45.2%). Daily application of treatment took <= 5 min for 86.1% of patients using gel and 71.0% of patients using ointment. Conclusion: This real-life study has demonstrated similar effectiveness between the Cal/BD formulations. However, over a 52-week treatment period, patients reported greater treatment satisfaction with the gel, which was considered easier to use, faster to apply and overall a more convenient product

Two distinct AFLP types in three populations of marram grass (Ammophila arenaria in Wales)

The genetic structure of marram grass populations at coastal and inland locations, 200 m apart, was investigated at three sites by means of amplified fragment length polymorphism (AFLP) DNA markers. We expected a genetic differentiation between coastal and inland populations and more genetic variation in the coastal areas as a result of different events of colonization by different plant materials. An assignment test showed that the sampled Ammophila arenaria could be assigned to two groups based on AFLP data. The spatial distribution of the two AFLP types of A. arenaria varied with sampling location. In two of the three locations, mainly one type (1) was found in the newly formed dunes. This type did also occur further landward, but the second type (2) was preferentially found in inland populations. Genetic diversity was very low and of similar value in both coastal and inland populations. For each site, outlier loci with respect to FST value were identified, which may be indicative of different selection pressures in coastal compared with inland clusters. However, no identical outlier loci were found at all three sites. Possible explanations for the observed difference in distribution of type 1 and 2 populations between coastal and inland sites are discusse

Structure-stiffness relation of live mouse brain tissue determined by depth-controlled indentation mapping

The mechanical properties of brain tissue play a pivotal role in neurodevelopment and neurological disorders. Yet, at present, there is no consensus on how the different structural parts of the tissue contribute to its stiffness variations. Here, we have gathered depth-controlled indentation viscoelasticity maps of the hippocampus of isolated horizontal live mouse brain sections. Our results confirm the highly viscoelestic nature of the material and clearly show that the mechanical properties correlate with the different morphological layers of the samples investigated. Interestingly, the relative cell nuclei area seems to negatively correlate with the stiffness observed

Nonmigratory online deadline scheduling on multiprocessors

In this paper we consider multiprocessor scheduling with hard deadlines and investigate the cost of eliminating migration in the online setting. Let I be any set of jobs that can be completed by some migratory offline schedule on m processors. We show that I can also be completed by a nonmigratory online schedule using m speed-5.828 processors (i.e., processors 5.828 times faster). This result supplements the previous results that I can also be completed by a non-migratory offline schedule using 6m unit-speed processors [B. Kalyanasundaram and K. R. Pruhs, J. Algorithms, 38 (2001), pp. 2-24] or a migratory online schedule using m speed-2 processors [C. A. Phillips et al., Algorithmica. 32 (2002), pp. 163-200]. Our result is based on a simple conservative scheduling algorithm called PARK, which commits a processor to a job only when the processor has zero commitment before its deadline. A careful analysis of PARK further shows that the processor speed can be reduced arbitrarily close to 1 by exploiting more processors (say, using 16m speed-1.8 processors). PARK also finds application in overloaded systems; it gives the first online nonmigratory algorithm that can exploit moderately faster processors to match the performance of any migratory offline algorithm. © 2005 Society for Industrial and Applied Mathematics.published_or_final_versio

The Stochastic Volatility in Mean Model

In this paper we present an exact maximum likelihood treatment forthe estimation of a Stochastic Volatility in Mean(SVM) model based on Monte Carlo simulation methods. The SVM modelincorporates the unobserved volatility as anexplanatory variable in the mean equation. The same extension isdeveloped elsewhere for Autoregressive ConditionalHeteroskedastic (ARCH) models, known as the ARCH in Mean (ARCH-M)model. The estimation of ARCH models isrelatively easy compared with that of the Stochastic Volatility (SV)model. However, efficient Monte Carlo simulationmethods for SV models have been developed to overcome some of theseproblems. The details of modificationsrequired for estimating the volatility-in-mean effect are presentedin this paper together with a Monte Carlo study toinvestigate the small-sample properties of the SVM estimators. Takingthese developments of estimation methods intoaccount, we regard SV and SVM models as practical alternatives totheir ARCH counterparts and therefore it is ofinterest to study and compare the two classes of volatility models.We present an empirical study about theintertemporal relationship between stock index returns and theirvolatility for the United Kingdom, United States andJapan. This phenomenon has been discussed in the financial literaturebut has proved hard to find empirically; we findevidence of a negative but weak relationship