425 research outputs found
Hydra 1 data display system
System, named Hydra, generates charts, graphs, and printed matter on slides or conventional negatives and positives, and combines these media with a capability of storage on magnetic tape for future updating to accommodate engineering changes or contract modifications to be readily added to basic data
Community rotorcraft air transportation benefits and opportunities
Information about rotorcraft that will assist community planners in assessing and planning for the use of rotorcraft transportation in their communities is provided. Information useful to helicopter researchers, manufacturers, and operators concerning helicopter opportunities and benefits is also given. Three primary topics are discussed: the current status and future projections of rotorcraft technology, and the comparison of that technology with other transportation vehicles; the community benefits of promising rotorcraft transportation opportunities; and the integration and interfacing considerations between rotorcraft and other transportation vehicles. Helicopter applications in a number of business and public service fields are examined in various geographical settings
Climate and human forcing of Alpine river flow
River flow in Alpine environments is likely to be highly sensitive to
climate change because of the effects of warming upon snow and ice, and
hence the intra-annual distribution of river runoff. It is also likely
to be influenced strongly by human impacts both upon hydrology (e.g.
flow abstraction) and river regulation. This paper compares the river
flow and sediment flux of two Alpine drainage basins over the last 5 to
7 decades, one that is largely unimpacted by human activities, one
strongly impacted by flow abstraction for hydroelectricity. The analysis
shows that both river flow and sediment transport capacity are strongly
dependent upon the effects of temperature and precipitation availability
upon snow accumulation. As the latter tends to increase annual maximum
flows, and given the non-linear form of most sediment transport laws,
current warming trends may lead to increased sedimentation in Alpine
rivers. However, extension to a system impacted upon by flow abstraction
reveals the dominant effect that human activity can have upon river
sedimentation but also how human response to sediment management has
co-evolved with climate forcing to make disentangling the two very
difficult
Treatment response and remission in a double-blind, randomized, head-to-head study of lisdexamfetamine dimesylate and atomoxetine in children and adolescents with attention-deficit hyperactivity disorder
The Author(s) 2014. This article is published with open access at Springerlink.com Objectives A secondary objective of this head-to-head study of lisdexamfetamine dimesylate (LDX) and ato-moxetine (ATX) was to assess treatment response rates in children and adolescents with attention-deficit hyperactiv-ity disorder (ADHD) and an inadequate response to methylphenidate (MPH). The primary efficacy and safety outcomes of the study, SPD489-317 (ClinicalTrials.gov NCT01106430), have been published previously. Methods In this 9-week, double-blind, active-controlled study, patients aged 6ā17 years with a previous inadequate response to MPH were randomized (1:1) to dose-optimized LDX (30, 50 or 70 mg/day) or ATX (patients \70 kg: 0.5ā1.2 mg/kg/day, not to exceed 1.4 mg/kg/day; patients C70 kg: 40, 80 or 100 mg/day). Treatment response was a secondary efficacy outcome and was predefined as a reduction from baseline in ADHD Rating Scale IV (ADHD-RS-IV) total score of at least 25, 30 or 50 %. Sustained response was predefined as a reduction from baseline in ADHD-RS-IV total score (C25, C30 or C50 %) or a Clinical Global Impressions (CGI)āImprovement (CGIāI) score of 1 or 2 throughout weeks 4ā9. CGIā Severity (CGIāS) scores were also assessed, as an indicator of remission. Results A total of 267 patients were enrolled (LDX, n = 133; ATX, n = 134) and 200 completed the study (LDX, n = 99; ATX, n = 101). By week 9, significantly (p \ 0.01) greater proportions of patients receiving LDX than ATX met the response criteria of a reduction from baseline in ADHD-RS-IV total score of at least 25 % (90.5 vs. 76.7 %), 30 % (88.1 vs. 73.7 %) or 50 % (73.0 vs. 50.4 %). Sustained response rates were also signifi-cantly (p \ 0.05) higher among LDX-treated patient
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